GLORIA

GEOMAR Library Ocean Research Information Access

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • Wiley-Blackwell  (14)
  • 2010-2014  (14)
  • 1
    facet.materialart.
    Unknown
    Combination of radiofrequency ablation and sequential cellular immunotherapy improves progression-free survival for patients with hepatocellular carcinoma (2013)
    Wiley-Blackwell
    Details
    Publication Date: 2013-07-04
    Description: Hepatocellular carcinoma (HCC) recurs frequently after minimally invasive therapy. This study was to observe the efficiency and safety of the combined treatment of radiofrequency ablation (RFA) with cellular immunotherapy (CIT) for HCC patients. In this study, sixty-two patients with HCC who were treated with radical RFA were divided into two groups: RFA alone (32 patients) and RFA/CIT (30 patients). Autologous mononuclear cells were collected from the peripheral blood and separated by apheresis, and then induced into natural killer (NK) cells, γδT cells and cytokine-induced killer (CIK) cells. These cells were identified by flow cytometry with their specific antibodies and then were infused intravenously to RFA/CIT patients for 3 or 6 courses. The tumor recurrent status of these patients was evaluated with computed tomography (CT) or magnetic resonance imaging (MRI) every 3 months after RFA. Progression-free survival (PFS), liver function, viral load, and adverse effects were examined. The results implied that PFS was higher in RFA/CIT group than that in RFA group. In RFA/CIT group, six courses had better survival prognosis than three courses. Viral load of hepatitis C was decreased in two of three patients without antiviral therapy in RFA/CIT group, but was increased in RFA group. No significant adverse reaction was found in the patients with CIT. In summary, these preliminary results suggest that combination of sequential CIT with RFA for HCC patients was efficient and safe, and may be helpful in the prevention of the recurrence for the patients with HCC after RFA. © 2013 Wiley Periodicals, Inc.
    Print ISSN: 0020-7136
    Electronic ISSN: 1097-0215
    Topics: Biology , Medicine
    Published by Wiley-Blackwell
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 2
    facet.materialart.
    Unknown
    Experimental investigation and numerical simulation of marangoni effect induced by mass transfer during drop formation (2013)
    Wiley-Blackwell
    Details
    Publication Date: 2013-06-02
    Description: Marangoni effect induced by interphase mass transfer plays an important role in liquid-liquid extraction and reaction processes. The interaction of Marangoni effect and interphase mass transfer during drop formation at different injection rates and different initial solute concentrations was investigated by experiment and numerical simulation. The extraction fraction was measured and the corresponding correlation was proposed. The level set method coupled with mass transfer equation is for the first time used to simulate the mass transfer induced Marangoni effect during drop formation. The simulated drop volume, shape and extraction fraction are in good accordance with experimental data. Through the numerical simulation, it is found that the mass transfer in the first mass transfer period is the most efficient during drop formation when Marangoni convection occurs. © 2013 American Institute of Chemical Engineers AIChE J, 2013
    Print ISSN: 0001-1541
    Electronic ISSN: 1547-5905
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Published by Wiley-Blackwell on behalf of The American Institute of Chemical Engineers (AIChE).
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 3
    facet.materialart.
    Unknown
    The growth and dislocation characterization of Yb0.005Y0.848Lu0.147VO4 mixed laser crystal (2014)
    Wiley-Blackwell
    Details
    Publication Date: 2014-07-31
    Description: A new mixed laser crystal, Yb 0.005 Y 0.848 Lu 0.147 VO 4 , has been successfully grown using the Czochralski method. An ICP-OES was used to measure the concentrations of elements (Yb, Y, Lu, V) in the crystal, and the chemical formula was determined. X-ray powder diffraction analysis shows that the crystal has ZrSiO 4 structure. A pair of edge dislocations with certain orientation was observed by the HREM, and the orientation was confirmed by the calibration of the diffraction spots. The formation mechanism of this type dislocation was given by analysis on structure and thermal expansion of crystal. The suggestion to avoid these dislocations was also given. A Yb 0.005 Y 0.848 Lu 0.147 VO 4 mixed laser crystal was grown by the Czochralski method. HREM was firstly used to characterize the structure of dislocation in vanadates and observed a new morphology of dislocations. This pair of dislocation forms because of the anisotropy of thermal expansion, the weak connection and relatively big interplanar distance between the atom layers. Appropriately slow cooling rate should be used to avoid the dislocations.
    Print ISSN: 0232-1300
    Electronic ISSN: 1521-4079
    Topics: Geosciences , Physics
    Published by Wiley-Blackwell
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 4
    facet.materialart.
    Unknown
    HER2-positive patients receiving trastuzumab treatment have a comparable prognosis with HER2-negative advanced gastric cancer patients: A prospective cohort observation (2013)
    Wiley-Blackwell
    Details
    Publication Date: 2013-10-25
    Description: The monoclonal antibody trastuzumab has brought survival benefit to patients with advanced gastric cancer (AGC) that have human epidermal growth factor receptor 2 (HER2) over expression or amplification. This study was designed to compare the clinical outcomes of HER2-negative and HER2-positive AGC patients with or without trastuzumab treatment. There were three groups of patients enrolled for analysis. Group A was 51 HER2-positive AGC patients treated with trastuzumab and chemotherapy; group B was a matched control group of 47 HER2-positive patients who received chemotherapy only; group C was a matched group of 251 HER2-negative patients who received chemotherapy. All the patients were enrolled at Sun Yat-sen University Cancer Center or Zhongshan Hospital, Fudan University between January 2010 and December 2012. The primary endpoint was overall survival (OS). The Kaplan-Meier method and log-rank test were used for survival analysis. The median duration of follow-up was 13.5 months (range, 5-18.6 months). The median OS of these three groups of patients was 14.8 months, 11.3 months and 14.4 months respectively (P〈0.001). The survival difference between group A and B was significant, P〈0.001. Similarly, there was significant difference between group B and C, P〈0.001. Moreover the survival between group A and C was comparable, P=0.281. The median progression free survival for these three groups was 7.4, 6.0 and 7.2 months. Multivariate analysis confirmed that trastuzumab treatment was an independent prognostic factor in group A and B patients (P=0.017). HER2 positive was an independent adverse prognostic factor in group B and C patients (P=0.013). © 2013 Wiley Periodicals, Inc.
    Print ISSN: 0020-7136
    Electronic ISSN: 1097-0215
    Topics: Biology , Medicine
    Published by Wiley-Blackwell
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 5
    facet.materialart.
    Unknown
    Identification of miR-214 as a negative regulator of colorectal cancer liver metastasis via regulation of FGFR1 expression (2014)
    Wiley-Blackwell
    Details
    Publication Date: 2014-03-12
    Description: The purpose of this study is to identify miRNAs involved in the pathology of colorectal cancer (CRC) liver metastasis and investigate their underlying mechanisms. A total of 39 miRNAs were identified to be differentially expressed between 16 primary CRC tissues with liver metastases and 16 CRC tissues without liver metastases from 32 patients by Affymetric miRNA microarrays. A panel of 8 miRNAs were confirmed to be significantly and differentially expressed between CRC tissues with and without liver metastases through quantitative RT-PCR analysis in the 32 patients. In a validated cohort of 99 CRC patients (44 with and 55 without liver metastases), only miR-214 was validated to be significantly down-regulated in CRC with liver metastases, which was associated with an unfavorable prognosis. Ectopic expression of miR-214 suppressed proliferation, migration, and invasion in vitro , tumor growth and liver metastasis in an in vivo xenograft mouse model; whereas miR-214 knockdown promoted proliferation, migration, and invasion in CRC cell lines. Further studies indicated that fibroblast growth factor receptor 1 (FGFR1) was a potential target of miR-214. Restoring miR-214 expression in CRC cells decreased endogenous FGFR1 mRNA and protein levels. FGFR1 knockdown mimicked the tumor suppressive effect of miR-214 on CRC cells, while reintroduction of FGFR1 abolished the tumor suppressive effect of miR-214 on CRC cells. Moreover, miR-214 expression levels were inversely correlated with FGFR1 in CRC patients. Conclusion: Down-regulation of miR-214 expression was correlated with increased FGFR1 expression levels, which may contribute to increased CRC liver metastasis. miR-214 may serve as a potential marker to predict survival, and the miR-214-FGFR1 axis may be a therapeutic target in CRC patients. (H epatology 2014;)
    Print ISSN: 0270-9139
    Electronic ISSN: 1527-3350
    Topics: Medicine
    Published by Wiley-Blackwell on behalf of The American Association for the Study of Liver Diseases.
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 6
    facet.materialart.
    Unknown
    Empirical modeling of plasma-sheet pressure and three-dimensional force-balanced magnetospheric magnetic field structure: 1. Observation (2013)
    Wiley-Blackwell
    Details
    Publication Date: 2013-09-25
    Description: [1]  A three-dimensional (3D) magnetic field configuration in force balance with a realistic plasma pressure distribution can provide more accurate evaluation of the role of magnetic field on plasma sheet dynamics and M-I coupling. We used Geotail and THEMIS data to establish an empirical model for nightside equatorial isotropic plasma pressure to r  = 30 R E for Kp = 0–5 and for solar wind dynamic pressure (P SW ) = 1.5 and 3 nPa. The model pressure is used in the companion paper for modeling a 3D force-balanced pressure and magnetic field equilibrium. Larger convection during higher Kp drives the plasma sheet further earthward, resulting in larger increase of pressure and pressure gradient at smaller radial distance. On the other hand, magnetosphere compression by increasing P SW enhances pressure and pressure gradient mainly in the tail plasma sheet. While both pressure and radial gradients are enhanced with increasing Kp or P SW , there is no significant azimuthal pressure variation statistically under all Kp and P SW conditions. The empirical pressures well reproduce these statistical profiles with very high correlation coefficients. Additionally, comparisons with pressure gradients computed using two simultaneous measurements from two THEMIS spacecraft show reasonable agreement. Furthermore, our model provides more accurate pressure gradients than previous empirical models. The model magnetic field distributions obtained in the companion paper from requiring force balance with these empirical pressure profiles are also found to be consistent with the magnetic field observations, indicating that our equilibria well represent realistic 3D pressure and magnetic field configurations.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley-Blackwell on behalf of American Geophysical Union (AGU).
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 7
    facet.materialart.
    Unknown
    Novel protein pp3501 mediates the inhibitory effect of sodium butyrate on SH-SY5Y cell proliferation (2012)
    Wiley-Blackwell
    Details
    Publication Date: 2012-04-16
    Description: Sodium butyrate, a new potential therapeutic drug, improves the efficacy of chemo- and immunotherapy of cancer under unknown mechanisms. A novel gene pp3501 is significantly induced in SH-SY5Y neuroblastoma cells upon sodium butyrate treatment. Therefore, this study has cloned pp3501 cDNA by RT-PCR and generated its recombinant fusion protein and anti-serum subsequently. The pp3501 protein localized mainly in the nucleus, as detected by immunocytochemistry and the expression of pp3501-EGFP fusion protein. pp3501 inhibited the proliferation of SH-SY5Y cells, arrested the cell cycle at G1 phase, and sensitized the SH-SY5Y cells to sodium butyrate treatment. These results provide a new mechanism of sodium butyrate inhibiting cancer cell proliferation as well as a new avenue for the future research on the functions of pp3501. J. Cell. Biochem. © 2012 Wiley Periodicals, Inc.
    Electronic ISSN: 0091-7419
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Published by Wiley-Blackwell
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 8
    facet.materialart.
    Unknown
    First experience of high intensity focused ultrasound combined with transcatheter arterial embolization as local control for hepatoblastoma (2013)
    Wiley-Blackwell
    Details
    Publication Date: 2013-06-29
    Description: Objective: The purpose of this study was to assess the effectiveness of high-intensity focused ultrasound (HIFU) combined with transarterial chemoembolization (TACE) in treating pediatric hepatoblastoma. Methods: 12 patients with initially unresectable hepatoblastoma were enrolled in the study. All patients received chemotherapy, TACE and HIFU ablation. Follow-up materials were obtained in all patients. The tumor response, survival rate and complication were analyzed. Results: Completely ablation was achieved in 10 patients (83.3%), and the AFP level was also decreased to normal in these patients. The mean follow-up time was 13.3±1.8 months (range, 2-25 months). At the end of follow-up, 2 patients died from tumor progression, the rest 10 patients were alive. One patient was found to have lung metastasis after HIFU and had an operation to remove the lesion. The median survival time was 14 months, and the survival rates of 1, 2-year were 91.7% and 83.3%, respectively. Complication included fever, transient impairment of hepatic function and mild malformation of rib. Conclusion: HIFU combined with TACE is a safe and promising method with a low rate of severe complications. As a non-invasive approach, it may provide a novel locally therapy for patients with unresectable hepatoblastoma. (H EPATOLOGY 2013.)
    Print ISSN: 0270-9139
    Electronic ISSN: 1527-3350
    Topics: Medicine
    Published by Wiley-Blackwell on behalf of The American Association for the Study of Liver Diseases.
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 9
    facet.materialart.
    Unknown
    High IDH1 expression is associated with a poor prognosis in cytogenetically normal acute myeloid leukemia (2014)
    Wiley-Blackwell
    Details
    Publication Date: 2014-12-20
    Description: The prognostic value of IDH1 mutations has been systematically evaluated in acute myeloid leukemia ( AML) patients recently. However, the role of IDH1 expression in AML is still under exploration. To investigate the clinical significance, we analyzed the IDH1/2 expression in 320 patients with cytogenetically normal AML (CN-AML) by quantitative real-time reverse-transcription polymerase chain reaction (qRT-PCR). High expression of IDH1 was predominant in patients with FLT3- ITD and DNMT3A mutations, and less prevalent in cases with CEBPA double allele mutations. Strong association was observed between high IDH1 expression and low expression of microRNA 181 family. Prognosis was adversely affected by high IDH1 expression with shorter overall survival (OS) and event free survival (EFS) in the context of clinical characteristics including age, WBC, and gene mutations of NPM1 , FLT3 -ITD, CEBPA , IDH1 , IDH2 , and DNMT3A in CN-AML. Moreover, the clinical outcome of IDH1 expression in terms of OS, EFS and complete remission rate still remained in multivariate models in CN-AML. Importantly, the prognostic value was validated using the published microarray data from 79 adult patients treated according to the German AMLCG-1999 protocol. Our results demonstrated that high IDH1 expression is associated with a poor prognosis of CN-AML. This article is protected by copyright. All rights reserved.
    Print ISSN: 0020-7136
    Electronic ISSN: 1097-0215
    Topics: Biology , Medicine
    Published by Wiley-Blackwell
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
  • 10
    facet.materialart.
    Unknown
    The growth and spectral analysis of mixed crystal of Yb-doped Lu0.5Y0.5PO4 mixed crystals (2014)
    Wiley-Blackwell
    Details
    Publication Date: 2014-11-26
    Description: A new kind of 5 at% Yb-doped Lu 0.5 Y 0.5 PO 4 crystals were firstly grown by spontaneously nucleated high-temperature solution method using lead pyrophosphate (Pb 2 P 2 O 7 ) as the solvent. The X-ray powder diffraction (XRPD) patterns recorded at room temperature showed the crystals possessed tetragonal xenotime structure. The polarized absorption spectra and the fluorescence spectra of Yb:Lu x Y 1-x PO 4 were measured at room temperature, respectively. The results show that Yb:Lu x Y 1-x PO 4 mixed crystal will be a promising laser material if the crystal size and quality is further improved. A new kind of 5 at% Yb-doped Lu 0.5 Y 0.5 PO 4 crystals were firstly grown by spontaneously nucleated high-temperature solution method using lead pyrophosphate (Pb 2 P 2 O 7 ) as the solvent. The X-ray powder diffraction (XRPD) patterns recorded at room temperature showed the crystals possessed tetragonal xenotime structure. The polarized absorption spectra and the fluorescence spectra of Yb:Lu x Y 1-x PO 4 were measured at room temperature, respectively. The results show that Yb:Lu x Y 1-x PO 4 mixed crystal will be a promising laser material if the crystal size and quality is further improved.
    Print ISSN: 0232-1300
    Electronic ISSN: 1521-4079
    Topics: Geosciences , Physics
    Published by Wiley-Blackwell
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    PAPER CURRENT
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...