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  • Wiley-Blackwell  (14)
  • Wiley-VCH  (1)
  • 2010-2014  (15)
  • 1
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    Multifunctional Theranostic Red Blood Cells For Magnetic-Field-Enhanced in vivo Combination Therapy of Cancer (2014)
    Wiley-VCH
    In:  Advanced Materials, 26 (28). pp. 4794-4802.
    Details
    Publication Date: 2020-04-23
    Description: Red blood cells are attached to iron oxide nanoparticles pre-coated with chlorine e6, a photosensitizer, and then loaded with a chemotherapeutic drug, doxorubicin, to enable imaging-guided combined photodynamic and chemotherapy of cancer, achieving excellent synergistic therapeutic effects in an animal tumor model. This work highlights the great promise of integrating cell-based drug-delivery systems with nanotechnology as a biocompatible multifunctional platform for applications in cancer theranostics.
    Type: Article , PeerReviewed
    Format: text
    Format: text
    DOI: 10.1002/adma.201400158
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    OceanRep: Article in a Scientific Journal - peer-reviewed
  • 2
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    First experience of high intensity focused ultrasound combined with transcatheter arterial embolization as local control for hepatoblastoma (2013)
    Wiley-Blackwell
    Details
    Publication Date: 2013-06-29
    Description: Objective: The purpose of this study was to assess the effectiveness of high-intensity focused ultrasound (HIFU) combined with transarterial chemoembolization (TACE) in treating pediatric hepatoblastoma. Methods: 12 patients with initially unresectable hepatoblastoma were enrolled in the study. All patients received chemotherapy, TACE and HIFU ablation. Follow-up materials were obtained in all patients. The tumor response, survival rate and complication were analyzed. Results: Completely ablation was achieved in 10 patients (83.3%), and the AFP level was also decreased to normal in these patients. The mean follow-up time was 13.3±1.8 months (range, 2-25 months). At the end of follow-up, 2 patients died from tumor progression, the rest 10 patients were alive. One patient was found to have lung metastasis after HIFU and had an operation to remove the lesion. The median survival time was 14 months, and the survival rates of 1, 2-year were 91.7% and 83.3%, respectively. Complication included fever, transient impairment of hepatic function and mild malformation of rib. Conclusion: HIFU combined with TACE is a safe and promising method with a low rate of severe complications. As a non-invasive approach, it may provide a novel locally therapy for patients with unresectable hepatoblastoma. (H EPATOLOGY 2013.)
    Print ISSN: 0270-9139
    Electronic ISSN: 1527-3350
    Topics: Medicine
    Published by Wiley-Blackwell on behalf of The American Association for the Study of Liver Diseases.
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  • 3
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    Combination of radiofrequency ablation and sequential cellular immunotherapy improves progression-free survival for patients with hepatocellular carcinoma (2013)
    Wiley-Blackwell
    Details
    Publication Date: 2013-07-04
    Description: Hepatocellular carcinoma (HCC) recurs frequently after minimally invasive therapy. This study was to observe the efficiency and safety of the combined treatment of radiofrequency ablation (RFA) with cellular immunotherapy (CIT) for HCC patients. In this study, sixty-two patients with HCC who were treated with radical RFA were divided into two groups: RFA alone (32 patients) and RFA/CIT (30 patients). Autologous mononuclear cells were collected from the peripheral blood and separated by apheresis, and then induced into natural killer (NK) cells, γδT cells and cytokine-induced killer (CIK) cells. These cells were identified by flow cytometry with their specific antibodies and then were infused intravenously to RFA/CIT patients for 3 or 6 courses. The tumor recurrent status of these patients was evaluated with computed tomography (CT) or magnetic resonance imaging (MRI) every 3 months after RFA. Progression-free survival (PFS), liver function, viral load, and adverse effects were examined. The results implied that PFS was higher in RFA/CIT group than that in RFA group. In RFA/CIT group, six courses had better survival prognosis than three courses. Viral load of hepatitis C was decreased in two of three patients without antiviral therapy in RFA/CIT group, but was increased in RFA group. No significant adverse reaction was found in the patients with CIT. In summary, these preliminary results suggest that combination of sequential CIT with RFA for HCC patients was efficient and safe, and may be helpful in the prevention of the recurrence for the patients with HCC after RFA. © 2013 Wiley Periodicals, Inc.
    Print ISSN: 0020-7136
    Electronic ISSN: 1097-0215
    Topics: Biology , Medicine
    Published by Wiley-Blackwell
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  • 4
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    The growth and dislocation characterization of Yb0.005Y0.848Lu0.147VO4 mixed laser crystal (2014)
    Wiley-Blackwell
    Details
    Publication Date: 2014-07-31
    Description: A new mixed laser crystal, Yb 0.005 Y 0.848 Lu 0.147 VO 4 , has been successfully grown using the Czochralski method. An ICP-OES was used to measure the concentrations of elements (Yb, Y, Lu, V) in the crystal, and the chemical formula was determined. X-ray powder diffraction analysis shows that the crystal has ZrSiO 4 structure. A pair of edge dislocations with certain orientation was observed by the HREM, and the orientation was confirmed by the calibration of the diffraction spots. The formation mechanism of this type dislocation was given by analysis on structure and thermal expansion of crystal. The suggestion to avoid these dislocations was also given. A Yb 0.005 Y 0.848 Lu 0.147 VO 4 mixed laser crystal was grown by the Czochralski method. HREM was firstly used to characterize the structure of dislocation in vanadates and observed a new morphology of dislocations. This pair of dislocation forms because of the anisotropy of thermal expansion, the weak connection and relatively big interplanar distance between the atom layers. Appropriately slow cooling rate should be used to avoid the dislocations.
    Print ISSN: 0232-1300
    Electronic ISSN: 1521-4079
    Topics: Geosciences , Physics
    Published by Wiley-Blackwell
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  • 5
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    Genome-wide screening revealed that miR-195 targets the TNF-α/NF-κB pathway by downregulating IKKα and TAB3 in hepatocellular carcinoma (2013)
    Wiley-Blackwell
    Details
    Publication Date: 2013-03-12
    Description: NF-κB is an important factor linking inflammation and tumorigenesis. In this study, we experimentally demonstrated through a high-throughput luciferase reporter screen that NF-κB signaling can be directly targeted by nearly 29 microRNAs (miRNAs). Many of these miRNAs can directly target NF-κB signaling nodes by binding to their 3′ UTRs. miR-195, a member of miR-15 family, is frequently downregulated in gastrointestinal cancers, especially in hepatocellular carcinoma (HCC). Expression level of miR-195 is inversely correlated with HCC tumor size. We further show that miR-195 suppresses cancer cell proliferation and migration in vitro and reduces tumorigenicity and metastasis in vivo. Additionally, miR-195 may exert its tumor suppressive function by decreasing the expression of multiple NF-κB downstream effectors via the direct targeting of IKKα and TAB3. Conclusion: Our findings indicate that multiple miRNAs are involved in the NF-κB signaling pathway and that miR-195 plays important inhibitory roles in cancer progression and may be a potential therapeutic target. (H EPATOLOGY 2013.)
    Print ISSN: 0270-9139
    Electronic ISSN: 1527-3350
    Topics: Medicine
    Published by Wiley-Blackwell on behalf of The American Association for the Study of Liver Diseases.
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  • 6
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    catena-Poly[[[diaqua[3-(pyridin-4-yl)benzoato-κ2O,O′]terbium(III)]-bis[μ-3-(pyridin-4-yl)benzoato-κ2O:O′]] monohydrate] (2012)
    Wiley-Blackwell
    Details
    Publication Date: 2012-11-13
    Description: In the title compound, {[Tb(C 12 H 8 NO 2 ) 3 (H 2 O) 2 ]·H 2 O} n , the Tb III cation is in an eight-coordinate environment, ligated by six carboxylate O atoms from five 3-(pyridin-4-yl)benzoate ( L ) ligands and by two O atoms from water molecules. The cations are bridged by the carboxylate O atoms of the L ligands to form a two-stranded polymeric chain which is assembled into a three-dimensional supramolecular network through regular interchain O—H...N hydrogen bonding. On excitation at 320 nm, the title compound displays a series of emissions, which were assigned to the characteristic electronic transitions of Tb III .
    Print ISSN: 0108-2701
    Electronic ISSN: 1600-5759
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Published by Wiley-Blackwell on behalf of International Union of Crystallography (IUCr).
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  • 7
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    Novel protein pp3501 mediates the inhibitory effect of sodium butyrate on SH-SY5Y cell proliferation (2012)
    Wiley-Blackwell
    Details
    Publication Date: 2012-04-16
    Description: Sodium butyrate, a new potential therapeutic drug, improves the efficacy of chemo- and immunotherapy of cancer under unknown mechanisms. A novel gene pp3501 is significantly induced in SH-SY5Y neuroblastoma cells upon sodium butyrate treatment. Therefore, this study has cloned pp3501 cDNA by RT-PCR and generated its recombinant fusion protein and anti-serum subsequently. The pp3501 protein localized mainly in the nucleus, as detected by immunocytochemistry and the expression of pp3501-EGFP fusion protein. pp3501 inhibited the proliferation of SH-SY5Y cells, arrested the cell cycle at G1 phase, and sensitized the SH-SY5Y cells to sodium butyrate treatment. These results provide a new mechanism of sodium butyrate inhibiting cancer cell proliferation as well as a new avenue for the future research on the functions of pp3501. J. Cell. Biochem. © 2012 Wiley Periodicals, Inc.
    Electronic ISSN: 0091-7419
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Published by Wiley-Blackwell
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  • 8
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    Effect of injection zone cracking on fluid catalytic cracking (2012)
    Wiley-Blackwell
    Details
    Publication Date: 2012-08-08
    Description: Fluid catalytic cracking (FCC) is a refining process for converting heavy oils to valuable products such as gasoline and olefins. Modeling of this process is quite challenging. A common assumption has been that vaporization is instantaneously fast and cracking is negligible in the injection zone. Relaxing this assumption, here we develop an approach for quantifying the effect of injection zone cracking on FCC performance. The approach combines a Lagrangian description of the spray behavior with an Eulerian modeling of transport-cracking coupling in the FCC riser. Included in the model are droplet vaporization, a four-lump kinetic network, spray penetration trajectory, solid-fluid and solid-solid collisions, and multi-spray interactions. Parametric studies show that precracking in the injection zone plays an important role in steering the overall performance of an FCC riser. The model developed here can accommodate a large number of reactions, thus allowing for composition-based modeling of the FCC process. © 2012 American Institute of Chemical Engineers AIChE J, 2012
    Print ISSN: 0001-1541
    Electronic ISSN: 1547-5905
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Published by Wiley-Blackwell on behalf of The American Institute of Chemical Engineers (AIChE).
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  • 9
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    Experimental investigation and numerical simulation of marangoni effect induced by mass transfer during drop formation (2013)
    Wiley-Blackwell
    Details
    Publication Date: 2013-06-02
    Description: Marangoni effect induced by interphase mass transfer plays an important role in liquid-liquid extraction and reaction processes. The interaction of Marangoni effect and interphase mass transfer during drop formation at different injection rates and different initial solute concentrations was investigated by experiment and numerical simulation. The extraction fraction was measured and the corresponding correlation was proposed. The level set method coupled with mass transfer equation is for the first time used to simulate the mass transfer induced Marangoni effect during drop formation. The simulated drop volume, shape and extraction fraction are in good accordance with experimental data. Through the numerical simulation, it is found that the mass transfer in the first mass transfer period is the most efficient during drop formation when Marangoni convection occurs. © 2013 American Institute of Chemical Engineers AIChE J, 2013
    Print ISSN: 0001-1541
    Electronic ISSN: 1547-5905
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Published by Wiley-Blackwell on behalf of The American Institute of Chemical Engineers (AIChE).
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  • 10
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    Identification of miR-214 as a negative regulator of colorectal cancer liver metastasis via regulation of FGFR1 expression (2014)
    Wiley-Blackwell
    Details
    Publication Date: 2014-03-12
    Description: The purpose of this study is to identify miRNAs involved in the pathology of colorectal cancer (CRC) liver metastasis and investigate their underlying mechanisms. A total of 39 miRNAs were identified to be differentially expressed between 16 primary CRC tissues with liver metastases and 16 CRC tissues without liver metastases from 32 patients by Affymetric miRNA microarrays. A panel of 8 miRNAs were confirmed to be significantly and differentially expressed between CRC tissues with and without liver metastases through quantitative RT-PCR analysis in the 32 patients. In a validated cohort of 99 CRC patients (44 with and 55 without liver metastases), only miR-214 was validated to be significantly down-regulated in CRC with liver metastases, which was associated with an unfavorable prognosis. Ectopic expression of miR-214 suppressed proliferation, migration, and invasion in vitro , tumor growth and liver metastasis in an in vivo xenograft mouse model; whereas miR-214 knockdown promoted proliferation, migration, and invasion in CRC cell lines. Further studies indicated that fibroblast growth factor receptor 1 (FGFR1) was a potential target of miR-214. Restoring miR-214 expression in CRC cells decreased endogenous FGFR1 mRNA and protein levels. FGFR1 knockdown mimicked the tumor suppressive effect of miR-214 on CRC cells, while reintroduction of FGFR1 abolished the tumor suppressive effect of miR-214 on CRC cells. Moreover, miR-214 expression levels were inversely correlated with FGFR1 in CRC patients. Conclusion: Down-regulation of miR-214 expression was correlated with increased FGFR1 expression levels, which may contribute to increased CRC liver metastasis. miR-214 may serve as a potential marker to predict survival, and the miR-214-FGFR1 axis may be a therapeutic target in CRC patients. (H epatology 2014;)
    Print ISSN: 0270-9139
    Electronic ISSN: 1527-3350
    Topics: Medicine
    Published by Wiley-Blackwell on behalf of The American Association for the Study of Liver Diseases.
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