In:
American Journal of Reproductive Immunology, Wiley, Vol. 68, No. 5 ( 2012-11), p. 408-417
Abstract:
The mi R ‐196a2 T 〉 C and mi R ‐499 A 〉 G polymorphisms have been reported to be genetic risk factors for recurrent spontaneous abortion; however, that previous study focused on the genetic analyses of pregnant women rather than aborted fetuses. Because annexin A 1 is a target of mi R ‐196a2 and is related to anti‐inflammation, mi R ‐196a2 may be immunologically important. Moreover, mi R ‐146a , mi R ‐149 , mi R ‐196a2 , and mi R ‐499 have shown associations with immune responses. Method of study One hundred and eighty‐two spontaneously aborted fetuses ( SAF s) were 〈 20 weeks of gestational age. The control subjects were 101 healthy children and 302 adults collected from a convenience sample. Polymerase chain reaction and restriction fragment length polymorphism analysis was performed to identify the mi R ‐146a C 〉 G , mi R ‐149 T 〉 C , mi R ‐196a2 T 〉 C , and mi R ‐499 A 〉 G genotypes. Results Chromosomally normal SAF s had significantly different frequencies of the mi R ‐196a2 CC , mi R ‐146a CC / mi R ‐196a2 CC , and mi R ‐149 TT / mi R ‐196a2 CC genotypes compared with control subjects. Conclusions mi R ‐196a2 CC , mi R ‐146a CC / mi R ‐196a2 CC , and mi R ‐149 TT / mi R ‐196a2 CC in fetuses are possible risk factors for spontaneous abortion.
Type of Medium:
Online Resource
ISSN:
1046-7408
,
1600-0897
DOI:
10.1111/aji.2012.68.issue-5
Language:
English
Publisher:
Wiley
Publication Date:
2012
detail.hit.zdb_id:
2024667-5
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