In:
Thoracic Cancer, Wiley, Vol. 4, No. 4 ( 2013-11), p. 405-409
Abstract:
The N ational L ung S creening T rial revealed that low dose computed tomography ( CT ) screening reduced lung cancer mortality by 20%. However, nearly all (96.4%) of the positive screening results were false‐positive. A higher false‐positive rate ( FPR ) is expected in K orea, where the prevalence of tuberculosis and parasitic diseases are high. Material and methods We retrospectively reviewed the records of 1587 cases (906 males, 57.1%; 495 females, 31.2%) in which chest CT was used for health screening from 2006 to 2011 in one institution. The mean ± standard deviation age of the subjects was 62.7 ± 5.7 years and 495 (31.2%) subjects had a smoking history. Results Three hundred and thirty six subjects (21.2%) had non‐calcified pulmonary nodules ( NCPNs ) described as solid nodules ( n = 319), masses ( n = 15) or pure or mixed ground glass opacities ( n = 36). The incidence of NCPNs was 23.8% in smokers and 20.0% in non‐smokers ( P = 0.08). During a median follow up duration of 37 months (range, 0–67 months), eight subjects were confirmed to have lung cancer. Positive predictive value ( PPV ) of positive CT screening was 2.4% and FPR was 97.6%. Among 495 subjects who had a smoking history, 118 subjects displayed NCPNs (23.8%) and four patients were diagnosed with lung cancer, with a PPV and FPR of 3.4% and 96.6%, respectively. Conclusion CT screening has low PPV and high FPR , even in subjects with a high risk of lung cancer.
Type of Medium:
Online Resource
ISSN:
1759-7706
,
1759-7714
DOI:
10.1111/tca.2013.4.issue-4
DOI:
10.1111/1759-7714.12038
Language:
English
Publisher:
Wiley
Publication Date:
2013
detail.hit.zdb_id:
2559245-2
Permalink