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  • SAGE Publications  (45)
  • 2010-2014  (45)
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  • SAGE Publications  (45)
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  • 11
    Online Resource
    Online Resource
    Prognostic Effect of Age on Survival of Patients with Stage I Adenocarcinoma of the Lung
    SAGE Publications ; 2012
    In:  Tumori Journal Vol. 98, No. 1 ( 2012-01), p. 99-104
    Details
    In: Tumori Journal, SAGE Publications, Vol. 98, No. 1 ( 2012-01), p. 99-104
    Abstract: It is still unclear whether age is an independent prognostic factor in patients with stage I NSCLC. Methods Five hundred and sixty-nine patients with stage I adenocarinoma who underwent surgical resection as first treatment were included. The effect on overall survival of age, gender, smoking habits, Charlson comorbidity index score (CCIS), type of surgery, tumor size and lymphatic or blood vessel invasion was analyzed. Results When the patients were divided into four groups according to quartiles of age, distributions of gender, smoking habit, CCIS, histology, blood vessel invasion and adjuvant chemotherapy were significantly different among the four groups. Age, gender, smoking habit, CCIS, tumor size and lymphatic and blood vessel invasion were significantly associated with overall survival of the patients in Kaplan-Meier analysis (logrank, P 〈 0.001, P 〈 0.001, P = 0.029, P 〈 0.001, P = 0.001, P = 0.001 and P = 0.007, respectively). Moreover, the highest quartile of age (over 68 years old) was a prominent determinant for a worse prognosis after adjustment for the confounding variables using a Cox proportional hazard model (adjusted hazard ratio = 2.735, 95% confidence interval = 1.623–4.608, P 〈 0.001). Conclusions The findings suggest that age is an important determinant of overall survival in patients with stage I adenocarcinoma. Therefore, age should be considered in classifying the patients into groups of higher or lower risk for death as well as in designing clinical trials.
    Type of Medium: Online Resource
    ISSN: 0300-8916 , 2038-2529
    URL: Article
    DOI: 10.1177/030089161209800114
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 280962-X
    detail.hit.zdb_id: 2267832-3
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  • 12
    Online Resource
    Online Resource
    Surgical Treatment of Non-Diabetic Chronic Osteomyelitis Involving the Foot and Ankle
    SAGE Publications ; 2012
    In:  Foot & Ankle International Vol. 33, No. 2 ( 2012-02), p. 128-132
    Details
    In: Foot & Ankle International, SAGE Publications, Vol. 33, No. 2 ( 2012-02), p. 128-132
    Abstract: Background: We evaluated the clinical characteristics and treatment outcomes of patients with chronic osteomyelitis in the foot and ankle in patients without diabetes. Methods: We reviewed 15 patients treated for chronic osteomyelitis involving the foot and ankle between September 2004 and March 2007. Patients with diabetes mellitus or who were immunocompromised were excluded. The cause of osteomyelitis, sites of occurrence, causative pathogens, and invasion of the adjacent joint(s) were reviewed, then the clinical characteristics were analyzed. Magnetic resonance imaging was performed to clarify the extent of infection and invasion of the adjacent joint. Surgical management included wide debridement, dead space control, and arthrodesis if there was invasion of the adjacent joint. The mean postoperative followup period was 3.3 years, during which recurrences and complications were evaluated. Results: Extrinsic causes accounted for 86.7% of the chronic osteomyelitis involving the foot and ankle. The most common cause of osteomyelitis was trauma with ten cases due to complications following fractures or dislocation. Methicillin-resistant Staphylococcus aureus and Pseudomonas were the most common causative pathogens. In 46.7% of the patients, the adjacent joint was involved and an arthrodesis was performed. The mean length of the hospital stay was 39.1 days. The average of number of surgeries was two. Fourteen of 15 patients had no recurrence. Conclusion: For the successful treatment of chronic osteomyelitis involving the foot and ankle, an arthrodesis based on invasion of the adjacent joint as well as wide debridement and dead space control was successful in this series. Level of Evidence: IV, Retrospective Case Series
    Type of Medium: Online Resource
    ISSN: 1071-1007 , 1944-7876
    URL: Article
    DOI: 10.3113/FAI.2012.0128
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2129503-7
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  • 13
    Online Resource
    Online Resource
    Therapeutic Effect of Broussonetia papyrifera and Lonicera japonica in Ovalbumin-induced Murine Asthma Model
    SAGE Publications ; 2013
    In:  Natural Product Communications Vol. 8, No. 11 ( 2013-11), p. 1934578X1300801-
    Details
    In: Natural Product Communications, SAGE Publications, Vol. 8, No. 11 ( 2013-11), p. 1934578X1300801-
    Abstract: Broussonetia papyrifera (L.) Vent. and Lonicera japonica Thunb. have been used in recent medicinal research for their antioxidative and anti-inflammatory properties. The present study investigated the therapeutic efficacy of B. papyrifera and L. japonica ethanolic extracts in a murine model of ovalbumin-induced asthma, in which intra-peritoneal (IP) injections and aerosol ovalbumin delivery were used to induce allergic asthma. Bronchioalveolar lavage fluid (BALF), serum samples, lungs and livers were collected from the experimental groups. In the groups treated with B. papyrifera and L. japonica extracts, CD3, CD4, serum IgE and IL-4 levels; activities of matrix metalloproteinase (MMP)-2 and MMP-9; and eotaxin levels in the BALF significantly decreased to near normal levels. Results of a histopathological analysis showed that the level of inflammation and mucous secretions reduced in the treated groups compared to the corresponding levels in the other groups. Moreover, results of a serum enzymatic analysis showed the non-toxic nature of the extracts in the B. papyrifera and L. japonica treated groups. Taken together, these results clearly indicate that the B. papyrifera and L. japonica extracts may be very effective against asthma and inflammation related diseases.
    Type of Medium: Online Resource
    ISSN: 1934-578X , 1555-9475
    URL: Article
    DOI: 10.1177/1934578X1300801127
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2430442-6
    SSG: 15,3
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  • 14
    Online Resource
    Online Resource
    Increased Expression of YKL-40 in Mild and Moderate/Severe Persistent Allergic Rhinitis and its Possible Contribution to Remodeling of Nasal Mucosa
    SAGE Publications ; 2013
    In:  American Journal of Rhinology & Allergy Vol. 27, No. 5 ( 2013-09), p. 372-380
    Details
    In: American Journal of Rhinology & Allergy, SAGE Publications, Vol. 27, No. 5 ( 2013-09), p. 372-380
    Abstract: Prominent expression of YKL-40 has been associated with pathological conditions characterized by tissue remodeling. We determined the expression level and distribution pattern of YKL-40 in allergic nasal mucosa and evaluated the effect of YKL-40 on the proliferation and migration of fibroblasts, the production of the mediators related to tissue remodeling, and collagen production. Additionally, the cytokine-driven regulation of YKL-40 expression was evaluated in cultured epithelial cells. Methods The expression of YKL-40 in normal, mild, and moderate/severe allergic nasal mucosa was evaluated using real-time polymerase chain reaction (PCR), Western blot, and immunohistochemistry. Fibroblast migration was observed using a scratch wound method, and proliferation was determined by the MTT methods. Expression of proteoglycans, transforming growth factor (TGF) beta1, MMP2, MMP9, TIMP1, TIMP2, and collagen concentration were analyzed in fibroblasts treated with YKL-40. The expression levels of YKL-40 in cultured epithelial cells were examined after stimulation with mediators including Th2 cytokines, interferon (IFN)gamma, and TNF-alpha with real-time PCR and ELISA. Results The expression of YKL-40 was up-regulated in allergic rhinitis and distributed in superficial epithelium, submucosal glands, and vascular endothelium, in addition to infiltrating cells. TGF-beta1, TIMP1, MMP9, and biglycan were up-regulated in fibroblasts on stimulation with YKL-40, accompanying increased proliferation and migration, and collagen production. IL-13, IFN-gamma, and TNF-alpha induced the increased production of YKL-40 in cultured epithelial cells. Conclusion YKL-40 is up-regulated in mild and moderate/severe persistent allergic rhinitis, and its expression can be regulated differentially by different cytokines, possibly contributing to the remodeling of nasal mucosa in allergic rhinitis.
    Type of Medium: Online Resource
    ISSN: 1945-8924 , 1945-8932
    URL: Article
    DOI: 10.2500/ajra.2013.27.3941
    RVK:
    XA 20278
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2013
    detail.hit.zdb_id: 2554548-6
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  • 15
    Online Resource
    Online Resource
    Increase of BM-MSC proliferation using L-DOPA on titanium surface in vitro
    SAGE Publications ; 2012
    In:  Journal of Biomaterials Applications Vol. 27, No. 2 ( 2012-08), p. 143-152
    Details
    In: Journal of Biomaterials Applications, SAGE Publications, Vol. 27, No. 2 ( 2012-08), p. 143-152
    Abstract: In order to increase biocompatibility, many dental implants have been studied by immobilization of biomolecules on biomaterials. We used l-3,4-dihydroxyphenylalanine (L-DOPA) as a biomolecule for surface-modified titanium. Water contact angles of nontreated titanium discs (negative control), etched titanium discs (positive control), and titanium discs treated with L-DOPA following the etching process (experimental group) were 82.4 ± 5.7°, 67.1 ± 0.56°, and 44.15 ± 0.91°, respectively. Using atomic force microscopy images, we were able to find L-DOPA, which adhered to the titanium surface. The number of human bone marrow mesenchymal stem cells (BM-MSCs) in the experimental group was much higher than that of cells in any other group. Quantification values of amine groups in the positive control and experimental groups were approximately 3 and 7.5 µg, respectively. Therefore, findings from our research suggested the possibility of a causal link between increased L-DOPA content and cell proliferation in BM-MSCs. Moreover, coating of the discs with L-DOPA can result in greater hydrophilicity of the titanium surface and enhancement of cell adhesion and mitochondrial activity .
    Type of Medium: Online Resource
    ISSN: 0885-3282 , 1530-8022
    URL: Article
    DOI: 10.1177/0885328210397679
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2072559-0
    SSG: 12
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  • 16
    Online Resource
    Online Resource
    Effects of nortriptyline on QT prolongation: A safety pharmacology study
    SAGE Publications ; 2011
    In:  Human & Experimental Toxicology Vol. 30, No. 10 ( 2011-10), p. 1649-1656
    Details
    In: Human & Experimental Toxicology, SAGE Publications, Vol. 30, No. 10 ( 2011-10), p. 1649-1656
    Abstract: Nortriptyline, a second-generation tricyclic antidepressant, is an active metabolite of amitriptyline. Amitriptyline induces QT prolongation and torsades de pointes (TdP), which causes sudden death. We studied the cardiovascular safety of nortriptyline, including QT prolongation risk. We examined the effects of nortriptyline on the cardiovascular system in vivo and in vitro in accordance with the ICH-S7B guideline. We tested its effect on QT interval in conscious telemetered dogs. We also performed in vitro electrophysiological studies on hERG tail currents using stably transfected human embryonic kidney 293 (HEK293) cells. Action potential parameters were studied in isolated rabbit purkinje fibers. Nortriptyline dose-dependently blocked hERG current, with a tail IC 50 value of 2.20 ± 0.09 μM ( n = 4). In the APD assay, total amplitude, Vmax, and resting membrane potential were not significantly changed by 1 μM nortriptyline, but nortriptyline at 0.3 and 1 μM shortened APD 50 and APD 90 . Nortriptyline did not affect QTcV at 2 or 6 mg/kg, but slightly increased QTcV at 20 mg/kg. In conclusion, it is unlikely that nortriptyline affects the ventricular repolarization process at therapeutic dosages.
    Type of Medium: Online Resource
    ISSN: 0960-3271 , 1477-0903
    URL: Article
    DOI: 10.1177/0960327110396528
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
    detail.hit.zdb_id: 1483723-7
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  • 17
    Online Resource
    Online Resource
    Genetic and phenotypic characterization of methicillin-resistant staphylococci isolated from veterinary hospitals in South Korea
    SAGE Publications ; 2012
    In:  Journal of Veterinary Diagnostic Investigation Vol. 24, No. 3 ( 2012-05), p. 489-498
    Details
    In: Journal of Veterinary Diagnostic Investigation, SAGE Publications, Vol. 24, No. 3 ( 2012-05), p. 489-498
    Abstract: Staphylococci were isolated from veterinary staff, hospitalized animals, and medical equipment from 2 major tertiary veterinary hospitals in South Korea to investigate antimicrobial resistance and genetic relatedness. The detection rate for staphylococci was 55.2% (111/201 samples), and 11 species were identified among the collected staphylococcal strains. The most prevalent species were Staphylococcus pseudintermedius (52/111, 46.8%), Staphylococcus epidermidis (21/111, 18.9%), and Staphylococcus aureus (19/111, 17.1%). The methicillin-resistance rates of staphylococci isolated from veterinary staff and medical equipment were higher than those from hospitalized animals. The genotype of methicillin-resistant S. aureus (MRSA) strains in the current study was sequence type (ST)72-SCC mec IVc-t324, which is similar to the genotype of prevalent MRSA strains in human beings and food animals in South Korea. Among the mecA-positive S. pseudintermedius isolates, SCC mec V was most prevalent in strains originating from both veterinary staff and hospitalized animals. SCC mec IVa was detected in methicillin-resistant S. epidermidis, whereas SCC mec IVc was found in other methicillin-resistant, coagulase-negative staphylococci. The SCC mec typing, antimicrobial susceptibility tests, and pulsed field gel electrophoresis results showed that methicillin-resistant staphylococci dissemination between hospitalized animals and veterinary staff is possible in South Korean veterinary hospitals.
    Type of Medium: Online Resource
    ISSN: 1040-6387 , 1943-4936
    URL: Article
    DOI: 10.1177/1040638712440985
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2012
    detail.hit.zdb_id: 2265211-5
    SSG: 22
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  • 18
    Online Resource
    Online Resource
    Risk Factors Affecting Chronic Rupture of the Plantar Fascia
    SAGE Publications ; 2014
    In:  Foot & Ankle International Vol. 35, No. 3 ( 2014-03), p. 258-263
    Details
    In: Foot & Ankle International, SAGE Publications, Vol. 35, No. 3 ( 2014-03), p. 258-263
    Abstract: Prior to 1994, plantar fascia ruptures were considered as an acute injury that occurred primarily in athletes. However, plantar fascia ruptures have recently been reported in the setting of preexisting plantar fasciitis. We analyzed risk factors causing plantar fascia rupture in the presence of preexisting plantar fasciitis. Methods: We retrospectively reviewed 286 patients with plantar fasciitis who were referred from private clinics between March 2004 and February 2008. Patients were divided into those with or without a plantar fascia rupture. There were 35 patients in the rupture group and 251 in the nonrupture group. The clinical characteristics and risk factors for plantar fascia rupture were compared between the 2 groups. We compared age, gender, the affected site, visual analog scale pain score, previous treatment regimen, body mass index, degree of ankle dorsiflexion, the use of steroid injections, the extent of activity, calcaneal pitch angle, the presence of a calcaneal spur, and heel alignment between the 2 groups. Results: Of the assessed risk factors, only steroid injection was associated with the occurrence of a plantar fascia rupture. Among the 35 patients with a rupture, 33 had received steroid injections. The odds ratio of steroid injection was 33. Conclusion: Steroid injections for plantar fasciitis should be cautiously administered because of the higher risk for plantar fascia rupture. Level of Evidence: Level III, retrospective comparative study.
    Type of Medium: Online Resource
    ISSN: 1071-1007 , 1944-7876
    URL: Article
    DOI: 10.1177/1071100713514564
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2129503-7
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  • 19
    Online Resource
    Online Resource
    MRI of chondromyxoid fibroma
    SAGE Publications ; 2011
    In:  Acta Radiologica Vol. 52, No. 8 ( 2011-10), p. 875-880
    Details
    In: Acta Radiologica, SAGE Publications, Vol. 52, No. 8 ( 2011-10), p. 875-880
    Abstract: Chondromyxoid fibroma is a rare benign primary bone tumor of cartilage. Despite a characteristic radiographic appearance, chondromyxoid fibroma with atypical radiographic findings may mimic more common tumors. Purpose To describe the MR findings of chondromyxoid fibroma. Material and Methods MR images of 19 histopathologically confirmed chondromyxoid fibromas were retrospectively analyzed for signal intensity, periosteal reaction, adjacent abnormal bone marrow and soft tissue signal, and patterns of contrast enhancement. Results All cases of chondromyxoid fibroma showed hypointense to intermediate signal intensity and internal hyperintense foci were observed in seven (37%) cases on T1-weighted images. On T2-weighted images, all lesions were hyperintense: peripheral intermediate signal band with central hyperintense signal in 11 (58%) of 19 lesions, whereas diffusely hyperintense with heterogeneous pattern in eight (42%). Periosteal reaction was observed in 11 (58%) of 19 cases. Adjacent abnormal bone marrow or soft tissue signal was observed in 12 (63%) or 14 (74%) of 19 cases, respectively. On contrast-enhanced T1-weighted images, peripheral nodular enhancement was observed in 69% (11/16) and diffuse contrast enhancement was observed in 31% (5/16) with homogeneous ( n = 3) or heterogeneous ( n = 2) patterns. Among the cases with peripheral nodular enhancement, the peripheral nodular enhancing portion generally corresponded to the peripheral intermediate signal band on T2-weighted images, although the peripheral enhancement was not as wide as a band of intermediate signal intensity. On the other hand, the central non-enhancing portion generally corresponded to the central hyperintense signal intensity on T2-weighted images. Conclusion The helpful features of chondromyxoid fibroma are the peripheral intermediate signal band and central hyperintense signal on T2-weighted images, generally corresponding to the peripheral nodular enhancement and central non-enhancing portion on contrast-enhanced T1-weighted images, respectively.
    Type of Medium: Online Resource
    ISSN: 0284-1851 , 1600-0455
    URL: Article
    DOI: 10.1258/ar.2011.110180
    RVK:
    XA 10000
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2011
    detail.hit.zdb_id: 2024579-8
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  • 20
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    Online Resource
    Skin discolouration with acute onset parkinsonism secondary to systemic zirconium intoxication
    SAGE Publications ; 2014
    In:  Annals of Clinical Biochemistry: International Journal of Laboratory Medicine Vol. 51, No. 1 ( 2014-01), p. 97-100
    Details
    In: Annals of Clinical Biochemistry: International Journal of Laboratory Medicine, SAGE Publications, Vol. 51, No. 1 ( 2014-01), p. 97-100
    Abstract: A 72-year-old woman presented with suspected parkinsonism and discolouration of the skin especially on sun-exposed areas. Thorough investigation revealed systemic zirconium intoxication due to intake of metallic colloids as a home remedy as a cause of the skin colour change. There may be an association between skin discolouration and her parkinsonism. This is unique in that various clinical manifestations developed following systemic ingestion of zirconium and this should serve as a warning on the risk of taking illicit dietary supplements.
    Type of Medium: Online Resource
    ISSN: 0004-5632 , 1758-1001
    URL: Article
    DOI: 10.1177/0004563213492312
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2014
    detail.hit.zdb_id: 2041298-8
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