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  • S. Karger AG  (11)
  • 2010-2014  (11)
  • 1
    Online Resource
    Online Resource
    Clinical Significance of Chronic Kidney Disease and Atrial Fibrillation on Morbidity and Mortality in Patients with Acute Myocardial Infarction
    S. Karger AG ; 2014
    In:  American Journal of Nephrology Vol. 40, No. 4 ( 2014), p. 345-352
    Details
    In: American Journal of Nephrology, S. Karger AG, Vol. 40, No. 4 ( 2014), p. 345-352
    Abstract: 〈 b 〉 〈 i 〉 Background/Aims: 〈 /i 〉 〈 /b 〉 Atrial fibrillation (AF) often coexists with acute myocardial infarction (AMI), and chronic kidney disease (CKD) is a major risk for AMI. However, the combined impact of CKD and AF on the mortality and morbidity in AMI population has not been determined. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Between January 2004 and December 2009, a total of 4,738 AMI patients were enrolled prospectively. Patients were divided into four groups according to the combined status of CKD and AF. The primary endpoint was a combination of 5-year major adverse cardiac and cerebrovascular events (MACCE). 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The prevalence of AF was significantly higher in CKD patients than in non-CKD patients (6.76 vs. 3.31%, p 〈 0.001). The highest cumulative event rate of MACCE and death was observed in patients with both CKD and AF (68.5 and 64.0%), respectively. In multivariable analyses, compared with patients with neither AF nor CKD, hazard ratios (HR) for composite of MACCE were 1.66 (95% CI, 1.14-2.41), 1.24 (95% CI, 1.06-1.46), and 2.10 (95% CI, 1.42-3.13) for patients with AF only, those with CKD only, and those with both CKD and AF, respectively (p for interaction = 0.935). Patients with both CKD and AF had a greatest risk for all-cause mortality (HR 2.54; 95% CI, 1.60-4.53), and the significant synergistic interaction was observed between CKD and AF (p for interaction = 0.015). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 The combined effect of AF and CKD on the risk of MACCE after an AMI is stronger than any separate condition, and it confers a synergistic effect on the all-cause mortality risk.
    Type of Medium: Online Resource
    ISSN: 0250-8095 , 1421-9670
    URL: Article
    DOI: 10.1159/000368422
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2014
    detail.hit.zdb_id: 1468523-1
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  • 2
    Online Resource
    Online Resource
    RANTES Polymorphisms and the Risk of Graft-versus-Host Disease in Human Leukocyte Antigen-Matched Sibling Allogeneic Hematopoietic Stem Cell Transplantation
    S. Karger AG ; 2013
    In:  Acta Haematologica Vol. 129, No. 3 ( 2013), p. 137-145
    Details
    In: Acta Haematologica, S. Karger AG, Vol. 129, No. 3 ( 2013), p. 137-145
    Abstract: We investigated the association between RANTES (regulated upon activation, normal T cell expressed and secreted) polymorphisms and clinical outcomes in patients treated with allogeneic hematopoietic stem cell transplantation (allo-HSCT). Three RANTES gene polymorphisms, i.e. –403G/A (rs2107538), –28C/G (rs2280788) and In1.1T/C (rs2280789), were genotyped, and the effects of the genotypes and haplotypes of RANTES on clinical outcomes were analyzed. The competing risk regression analysis was used to investigate the relationship between the polymorphisms and the cumulative risk of graft-versus-host disease (GVHD). An AGC haplotype in a recessive model showed significant harmful effects on the cumulative risk of acute GVHD and relapse-free survival (adjusted hazard ratios 2.42 and 2.71, 95% confidence intervals 1.29–4.55 and 1.30–5.64; p = 0.018 and 0.024, respectively), whereas a GCT haplotype did not. RANTES polymorphisms were not significantly associated with overall survival and the risk of chronic GVHD. This study suggests that RANTES polymorphisms might be associated with the occurrence of acute GVHD rather than of chronic GVHD and also of relapse-free survival in the patients treated with allo-HSCT. Further larger prospective investigations are needed to establish the role of RANTES polymorphisms in patients treated with allo-HSCT.
    Type of Medium: Online Resource
    ISSN: 0001-5792 , 1421-9662
    URL: Article
    DOI: 10.1159/000343273
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2013
    detail.hit.zdb_id: 1481888-7
    detail.hit.zdb_id: 80008-9
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  • 3
    Online Resource
    Online Resource
    Airway Hyperresponsiveness Is Negatively Associated with Obesity or Overweight Status in Patients with Asthma
    S. Karger AG ; 2012
    In:  International Archives of Allergy and Immunology Vol. 159, No. 2 ( 2012), p. 187-193
    Details
    In: International Archives of Allergy and Immunology, S. Karger AG, Vol. 159, No. 2 ( 2012), p. 187-193
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Obesity is a risk factor for asthma in the general population, but the effect of obesity on airway hyperresponsiveness (AFHR) or airway inflammation in asthma is not clear. This study evaluated the relationship between obesity and asthma, assessing aspects of symptoms, AHR, and severity. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 In total, 852 patients with asthma diagnosed by asthma specialists based on AHR as confirmed by a methacholine bronchial provocation test, were enrolled from the Cohort for Reality and Evolution of Adult Asthma in Korea (COREA) adult asthma cohort. The intensity of AHR was assessed by the concentration of methacholine needed to cause a 20% decrease in FEV 〈 sub 〉 1 〈 /sub 〉 (PC 〈 sub 〉 20 〈 /sub 〉 ). Patients were classified into four categories based on body mass index (BMI): underweight ( 〈 18.5), normal weight (18.5–24.9), overweight (25.0–29.9), and obese (≥30). 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 BMI was negatively correlated with FEV 〈 sub 〉 1 〈 /sub 〉 (l), FVC (l), and FEV 〈 sub 〉 1 〈 /sub 〉 /FVC (%) in lung function tests. The prevalence of wheezing increased with higher BMI after adjustment for age, sex, smoking, medication history, and PC 〈 sub 〉 20 〈 /sub 〉 (p 〈 0.0001). logPC 〈 sub 〉 20 〈 /sub 〉 was lower in the normal weight group compared with the overweight group (p = 0.003). The risk of moderate or severe AHR (PC 〈 sub 〉 20 〈 /sub 〉 ≤ 4 mg/ml) decreased with increased BMI after adjustment for age, sex, smoking, and medication history (p 〈 i 〉 = 〈 /i 〉 0.035). 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Obesity is a risk factor for asthma in the general population, but obesity in asthmatic patients is negatively correlated with the intensity of AHR and is not related to asthma severity. Obesity is positively related with the prevalence of wheezing but negatively related to AHR in asthmatic patients.
    Type of Medium: Online Resource
    ISSN: 1018-2438 , 1423-0097
    URL: Article
    DOI: 10.1159/000335926
    RVK:
    XA 49650
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2012
    detail.hit.zdb_id: 1482722-0
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  • 4
    Online Resource
    Online Resource
    Polymorphisms near 〈b〉〈i〉Interleukin 28B〈/i〉〈/b〉 Gene Are Not Associated with Hepatitis B Virus Clearance, Hepatitis B e Antigen Clearance and Hepatocellular Carcinoma Occurrence
    S. Karger AG ; 2013
    In:  Intervirology Vol. 56, No. 2 ( 2013), p. 84-90
    Details
    In: Intervirology, S. Karger AG, Vol. 56, No. 2 ( 2013), p. 84-90
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Polymorphisms near the 〈 i 〉 IL28B 〈 /i 〉 gene have been proposed to be strongly associated with treatment response and the rate of spontaneous clearance of hepatitis C virus infection, and treatment response of hepatitis B virus (HBV) infection. In this study, we aimed to determine whether these polymorphisms could affect natural courses of HBV infection. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Genetic variations were identified through direct DNA sequencing using TaqMan assay in 1,439 patients with past or present HBV infection. Subjects included 404 spontaneously recovered patients, 313 chronic hepatitis B (CHB) patients, 305 liver cirrhosis (LC) patients and 417 hepatocellular carcinoma (HCC) patients. Three polymorphisms near the 〈 i 〉 IL28B 〈 /i 〉 gene, rs8099917T 〉 G, rs12979860C 〉 T and rs12980275A 〉 G, were identified. Associations between these polymorphisms and HBV clearance, hepatitis B e antigen (HBeAg) clearance as well as HCC occurrence among patients were analyzed using logistic regression analyses adjusted for age and gender. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 There were no significant associations between these polymorphisms and the HBV clearance both in CHB and LC groups. Similarly, these polymorphisms showed no significant associations with HBeAg clearance and the occurrence of HCC either. 〈 b 〉 〈 i 〉 Discussion: 〈 /i 〉 〈 /b 〉 No significant association was identified between polymorphisms near the 〈 i 〉 IL28B 〈 /i 〉 gene and the natural courses of chronic HBV infection, including the HBV clearance and HCC occurrence.
    Type of Medium: Online Resource
    ISSN: 0300-5526 , 1423-0100
    URL: Article
    DOI: 10.1159/000342526
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2013
    detail.hit.zdb_id: 1482863-7
    SSG: 12
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  • 5
    Online Resource
    Online Resource
    The Impact of the 2007 ATS/IDSA Diagnostic Criteria for Nontuberculous Mycobacterial Disease on the Diagnosis of Nontuberculous Mycobacterial Lung Disease
    S. Karger AG ; 2011
    In:  Respiration Vol. 82, No. 2 ( 2011), p. 124-129
    Details
    In: Respiration, S. Karger AG, Vol. 82, No. 2 ( 2011), p. 124-129
    Abstract: 〈 i 〉 Background: 〈 /i 〉 In 2007, the American Thoracic Society (ATS) and Infectious Disease Society of America (IDSA) published new diagnostic guidelines for nontuberculous mycobacterial (NTM) disease. Bacteriological criteria have become simpler compared to the 1997 ATS diagnostic criteria. 〈 i 〉 Objective: 〈 /i 〉 For assessing the impact of the 2007 ATS/IDSA diagnostic criteria, we compared the diagnosis rate and time to diagnosis of NTM lung disease using the 1997 and 2007 ATS guidelines. 〈 i 〉 Methods: 〈 /i 〉 Sixty-four patients who had excreted 〈 i 〉 Mycobacterium intracellulare 〈 /i 〉 , 〈 i 〉 M. avium 〈 /i 〉 , 〈 i 〉 M. abscessus 〈 /i 〉 or 〈 i 〉 M. kansasii 〈 /i 〉 at least one time in their respiratory specimens at Chonnam National University Hospital were reviewed. The 1997 ATS and 2007 ATS/IDSA guidelines were applied to these patients. 〈 i 〉 Results: 〈 /i 〉 Thirty-seven of 64 patients (57.8%) were diagnosed with NTM lung disease by the 1997 ATS criteria. When the 2007 ATS/IDSA criteria were applied, 6 patients were newly diagnosed with NTM lung disease. The diagnosis rate significantly increased from 57.8 to 67.2% (p 〈 0.001). The time to diagnosis in the 1997 ATS and 2007 ATS/IDSA guidelines was 46.4 ± 53.0 and 36.2 ± 38.5 days, respectively (p = 0.002). 〈 i 〉 Conclusion: 〈 /i 〉 These data suggest that we can shorten the time to diagnose NTM lung disease and diagnose more simply by using the 2007 ATS/IDSA guidelines. Further study will be needed to assess that these changes affect the management of NTM disease.
    Type of Medium: Online Resource
    ISSN: 0025-7931 , 1423-0356
    URL: Article
    DOI: 10.1159/000320254
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2011
    detail.hit.zdb_id: 1464419-8
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  • 6
    Online Resource
    Online Resource
    Adjuvant Chemotherapy for Small Bowel Adenocarcinoma after Curative Surgery
    S. Karger AG ; 2011
    In:  Oncology Vol. 80, No. 3-4 ( 2011), p. 208-213
    Details
    In: Oncology, S. Karger AG, Vol. 80, No. 3-4 ( 2011), p. 208-213
    Abstract: 〈 i 〉 Objectives: 〈 /i 〉 We evaluated prognostic factors affecting relapse-free survival (RFS) and overall survival (OS), and investigated the role of adjuvant chemotherapy in patients with small bowel adenocarcinoma (SBA). 〈 i 〉 Methods: 〈 /i 〉 Data from 52 patients with SBA who underwent curative surgery at the Asan Medical Center between January 1989 and December 2009 were retrospectively analyzed. Patients were divided into two groups: those who did (n = 23) and did not (n = 29) receive adjuvant chemotherapy. 〈 i 〉 Results: 〈 /i 〉 At a median follow-up of 32.2 months (range, 5.5–212.2 months), relapses had occurred in 17 patients (32.7%), with a 5-year RFS rate of 52.9% (95% CI, 39.3–66.5%), and 19 patients (36.5%) had died, with a 5-year OS rate of 59.0% (95% CI, 45.6–72.4%). The most frequent sites of relapse were the peritoneum and liver. Multivariate analysis showed that lymph node involvement was the only factor independently associated with poor RFS and OS. After inverse probability of treatment weighting adjustment, adjuvant chemotherapy did not enhance RFS [hazard ratio (HR), 1.399; 95% CI, 0.498–3.933] or OS (HR 0.797; 95% CI, 0.307–2.068). 〈 i 〉 Conclusions: 〈 /i 〉 Lymph node involvement is a predictor of poor prognosis in patients with SBA who undergo curative surgery.
    Type of Medium: Online Resource
    ISSN: 0030-2414 , 1423-0232
    URL: Article
    DOI: 10.1159/000328506
    RVK:
    XH 3305
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2011
    detail.hit.zdb_id: 1483096-6
    detail.hit.zdb_id: 250101-6
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  • 7
    Online Resource
    Online Resource
    Sorafenib Dose Escalation in the Treatment of Advanced Hepatocellular Carcinoma
    S. Karger AG ; 2012
    In:  Oncology Vol. 82, No. 2 ( 2012), p. 119-125
    Details
    In: Oncology, S. Karger AG, Vol. 82, No. 2 ( 2012), p. 119-125
    Abstract: 〈 i 〉 Objective: 〈 /i 〉 Although sorafenib has shown survival benefits in patients with hepatocellular carcinoma (HCC), many patients require discontinuation or dose reduction due to adverse events (AEs). We applied a dose escalation scheme to increase patient compliance and avoid AEs. 〈 i 〉 Methods: 〈 /i 〉 Of 267 HCC patients treated with first-line sorafenib, 25 at increased risk of AEs, including those with advanced liver cirrhosis, a history of liver transplantation, or cytopenia, received the dose escalation scheme. They started on a reduced dose of sorafenib which increased to the standard dosage according to tolerance in each patient. We analyzed the efficacy and safety of the dose escalation scheme. 〈 i 〉 Results: 〈 /i 〉 Patients with risk factors showed a lower disease control rate, shorter survival, and more frequently grade 3/4 AEs. Among patients presenting risk factors, the dose scheme did not affect the efficacy of sorafenib or survival, but reduced the incidence of grade 3/4 AEs. Rates of sorafenib discontinuation and dose reduction related to AEs were also lower in the dose escalation group. Dose escalation to the standard dose of sorafenib was achieved in 16 of the 25 patients in the dose escalation group (64.0%). After 2 weeks, the dose intensity of sorafenib did not differ between the two dose schemes. 〈 i 〉 Conclusions: 〈 /i 〉 The sorafenib dose escalation scheme may increase patient compliance and tolerance to prolonged treatment, thus enhancing the efficacy of sorafenib in patients at high risk of AEs or with poor tolerance. Further prospective analyses are needed to determine the usefulness of the dose escalation scheme.
    Type of Medium: Online Resource
    ISSN: 0030-2414 , 1423-0232
    URL: Article
    DOI: 10.1159/000336082
    RVK:
    XH 3305
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2012
    detail.hit.zdb_id: 1483096-6
    detail.hit.zdb_id: 250101-6
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  • 8
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    Validation and Comparison of CS-IHC4 Scores with a Nomogram to Predict Recurrence in Hormone Receptor-Positive Breast Cancers
    S. Karger AG ; 2014
    In:  Oncology Vol. 86, No. 5-6 ( 2014), p. 279-288
    Details
    In: Oncology, S. Karger AG, Vol. 86, No. 5-6 ( 2014), p. 279-288
    Abstract: The aim of this study was to both develop and validate a nomogram based on the Ki-67 index to predict recurrence. We constructed a nomogram using the Cox proportional hazards model with 953 N0 and N1 postoperative hormone receptor (HR)-positive breast cancer patients and validated it in an external cohort of 895 patients. A prognostic model that used classical variables, Adjuvant! Online, St. Gallen risk stratification, and the four immunohistochemistry (IHC) markers (IHC4 score) was created and assessed by the likelihood ratio & #x03C7; 〈 sup 〉 2 〈 /sup 〉 (LR- & #x03C7; 〈 sup 〉 2 〈 /sup 〉 ) test using the bootstrapping method. The nomogram showed an area under the receiver operating characteristic curve (AUC) of 0.75 (95% CI 0.72-0.77) in the training set. The validation set showed good discrimination with an AUC of 0.63 (95% CI 0.60-0.66). In the LR- & #x03C7; 〈 sup 〉 2 〈 /sup 〉 test, the nomogram score was found to be more informative than the IHC4 with clinical score (CS) [LR- & #x03C7; 〈 sup 〉 2 〈 /sup 〉 13.365 (1 d.f.); 95% CI 2.50-24.23 for CS-IHC4 + nomogram score vs. CS-IHC4] on distant recurrence-free survival. This study implies that the amount of prognostic information contained in the nomogram is superior to that in the CS-IHC4 score in HR-positive N0 and N1 breast cancer patients (NCT1273415).
    Type of Medium: Online Resource
    ISSN: 0030-2414 , 1423-0232
    URL: Article
    DOI: 10.1159/000362281
    RVK:
    XH 3305
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2014
    detail.hit.zdb_id: 1483096-6
    detail.hit.zdb_id: 250101-6
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  • 9
    Online Resource
    Online Resource
    Prognostic Role of Serum Lactate Dehydrogenase Beyond Initial Diagnosis: A Retrospective Analysis of Patients with Diffuse Large B Cell Lymphoma
    S. Karger AG ; 2013
    In:  Acta Haematologica Vol. 130, No. 4 ( 2013), p. 305-311
    Details
    In: Acta Haematologica, S. Karger AG, Vol. 130, No. 4 ( 2013), p. 305-311
    Abstract: 〈 b 〉 〈 i 〉 Background/Aims: 〈 /i 〉 〈 /b 〉 Baseline serum lactate dehydrogenase (LDH) level is a well-known prognostic factor in patients with non-Hodgkin's lymphoma; however, its role beyond initial diagnosis has not yet been defined. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 This study was conducted as a retrospective analysis of patients with diffuse large B cell lymphoma (DLBCL) treated with R-CHOP21, who had undergone regular checks for LDH during immunochemotherapy (n = 119) and during the posttreatment follow-up period after complete remission (CR; n = 100). The 119 patients were classified into 4 groups according to their baseline and change in LDH level during treatment, and an analysis of tumor response and survival was performed. The value of LDH as a predictor for relapse was evaluated among the patients with regular follow-up visits after achieving CR. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 An increased LDH level during immunochemotherapy had no impact on tumor response or survival, and only the LDH status ‘before' treatment was a prognostic marker. The sensitivity, specificity, positive predictive value and negative predictive value of serum LDH for detecting relapse after CR were 47.4, 86.5, 9.3 and 98.3%, respectively. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 The measurement of LDH level beyond initial diagnosis has no clear benefit in predicting disease progression or relapse in patients with DLBCL treated with R-CHOP21.
    Type of Medium: Online Resource
    ISSN: 0001-5792 , 1421-9662
    URL: Article
    DOI: 10.1159/000353127
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2013
    detail.hit.zdb_id: 1481888-7
    detail.hit.zdb_id: 80008-9
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  • 10
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    Online Resource
    Coexistence between Carotid Artery Stenosis and Colorectal Adenomatous Polyps in Middle-Aged Men
    S. Karger AG ; 2010
    In:  Digestion Vol. 81, No. 1 ( 2010), p. 20-26
    Details
    In: Digestion, S. Karger AG, Vol. 81, No. 1 ( 2010), p. 20-26
    Abstract: 〈 i 〉 Background: 〈 /i 〉 Colorectal neoplasia and cardiovascular disease appear to share common risk factors. This study aimed to investigate the association between the thickness of the intima-media complex (IMT) or carotid artery stenosis (CAS) on carotid artery ultrasonography and the presence of colorectal adenomas in middle-aged asymptomatic men. 〈 i 〉 Methods: 〈 /i 〉 This study was conducted among 1,877 asymptomatic male subjects, 40–59 years, who underwent both carotid artery ultrasonography and colonoscopy for routine health examination. Clinical information was collected from a standardized questionnaire, physical examination and blood tests. 〈 i 〉 Results: 〈 /i 〉 The prevalence of overall colorectal adenomatous polyps (APs) was 31.4% (591/1,877). The subjects were divided into two groups according to the presence of APs in the colorectum. The prevalence of IMT ≧10 mm was significantly higher in the subjects with CAS than in those without CAS (10.1 vs. 0.7%, p 〈 0.001). CAS was more prevalent in the AP-positive group than in the AP-negative group (40.5 vs. 30.2%, p = 0.001). Moreover, CAS was more prevalent in the advanced AP-positive group than in the advanced AP-negative group (15.2 vs. 8.2%, p = 0.048). 〈 i 〉 Conclusion: 〈 /i 〉 This study suggests that there is a relationship between colorectal AP and CAS, probably due to common risk factors.
    Type of Medium: Online Resource
    ISSN: 0012-2823 , 1421-9867
    URL: Article
    DOI: 10.1159/000217451
    RVK:
    XA 40650
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2010
    detail.hit.zdb_id: 1482218-0
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