In:
Digestion, S. Karger AG, Vol. 85, No. 1 ( 2012), p. 61-67
Abstract:
〈 i 〉 Background and Aim: 〈 /i 〉 Along with the widespread use of eradication for 〈 i 〉 Helicobacter pylori 〈 /i 〉 ( 〈 i 〉 H. pylori) 〈 /i 〉 , the incidence of gastric cancer after eradication has also been increasing. There is a need for clarification of the clinical and biological characteristics of these neoplasms. 〈 i 〉 Patients and Methods: 〈 /i 〉 We studied 27 cases of gastric cancer that developed after eradication (group AE). Out of the 27, we selected 26 with early-stage gastric cancer and compared them with 78 age-matched gastric cancer patients with 〈 i 〉 H. pylori 〈 /i 〉 infection (group Pos) and 20 patients without 〈 i 〉 H. pylori 〈 /i 〉 (group Neg). The patient with autoimmune gastritis was not included. Clinicopathological features, mucus patterns and Wnt5a expressions were compared among these groups. 〈 i 〉 Results: 〈 /i 〉 Among group AE patients, there were more males than females, and the tumor histology was mainly intestinal type, a significant difference from group Neg. In contrast, macroscopically, the tumors were predominantly of the flat-depressed type, a feature similar to that of group Neg but significantly different from that of group Pos. MUC2 and Wnt5a expression was significantly lower in group AE than in group Pos. 〈 i 〉 Conclusion: 〈 /i 〉 Gastric cancer development after eradication may have a carcinogenic pathway similar to that in cancer with 〈 i 〉 H. pylori 〈 /i 〉 infection, though macroscopic/biological features may be modified by eradication therapy.
Type of Medium:
Online Resource
ISSN:
0012-2823
,
1421-9867
Language:
English
Publisher:
S. Karger AG
Publication Date:
2012
detail.hit.zdb_id:
1482218-0
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