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  • 1
    Online Resource
    Online Resource
    Efficacy and Safety of Platinum Combination Chemotherapy Re-Challenge for Relapsed Patients with Non-Small-Cell Lung Cancer after Postoperative Adjuvant Chemotherapy of Cisplatin plus Vinorelbine
    S. Karger AG ; 2013
    In:  Chemotherapy Vol. 59, No. 4 ( 2013), p. 307-313
    Details
    In: Chemotherapy, S. Karger AG, Vol. 59, No. 4 ( 2013), p. 307-313
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 There is no standard therapy for relapsed patients who have received postoperative platinum-based adjuvant chemotherapy for resected non-small-cell lung cancer (NSCLC). We investigated the efficacy and safety of platinum combination chemotherapy re-challenge for such patients. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Medical records from 3 institutes from April 2005 to July 2012 were retrospectively reviewed. Patients who underwent complete surgical resection were eligible if they received postoperative adjuvant chemotherapy consisting of cisplatin plus vinorelbine once and then re-challenge with platinum combination chemotherapy. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Sixteen patients were enrolled in this study. After re-challenge with platinum combination chemotherapy, we observed an overall response rate of 31.2% (5/16) and a disease control rate of 81.2% (13/16). Median progression-free survival and overall survival from the start of the re-administration of platinum combination chemotherapy were 6.5 and 28.0 months, respectively. Frequently observed severe adverse events (≥grade 3) included neutropenia (31.2%), thrombocytopenia (31.2%), leukopenia (12.5%) and hyponatremia (12.5%). Frequently observed non-hematological toxicities (≥grade 2) were anorexia (37.5%) and nausea (37.5%). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Re-challenge with platinum combination chemotherapy was effective and safe; therefore, this therapy should be considered as a treatment option for relapsed patients after postoperative cisplatin-based adjuvant chemotherapy for resected NSCLC.
    Type of Medium: Online Resource
    ISSN: 0009-3157 , 1421-9794
    URL: Article
    DOI: 10.1159/000356155
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2013
    detail.hit.zdb_id: 1482111-4
    SSG: 15,3
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  • 2
    Online Resource
    Online Resource
    Sex Hormones Alter Th1 Responses and Enhance Granuloma Formation in the Lung
    S. Karger AG ; 2011
    In:  Respiration Vol. 81, No. 6 ( 2011), p. 491-498
    Details
    In: Respiration, S. Karger AG, Vol. 81, No. 6 ( 2011), p. 491-498
    Abstract: 〈 i 〉 Background: 〈 /i 〉 The lung is one of the sites of granulomatous responses, which are characterized by the recruitment and organization of activated macrophages and lymphocytes. There have been several reports that have shown that some pulmonary granulomatous diseases, such as sarcoidosis and nontuberculous mycobacterial disease, are likely to be characterized by a preponderance in postmenopausal females. Although sex hormones have been shown to play an important role in the regulation of the immune system, the influence of sex hormones on pulmonary granuloma formation is still unclear. 〈 i 〉 Objectives: 〈 /i 〉 The purpose of this study was to assess whether sex hormones are involved in granulomatous inflammation and to evaluate how sex hormones modulate this response in the lung. 〈 i 〉 Methods: 〈 /i 〉 Ovariectomized rats were used as an experimental postmenopausal model in which chronic pulmonary granulomatous inflammation was induced by intravenous injection of complete Freund’s adjuvant. 〈 i 〉 Results: 〈 /i 〉 Histological analysis of lung tissues demonstrated enhancement of granuloma formation in the ovariectomized group. Such enhanced granuloma formation was significantly associated with generalized Th1-biased cytokine production in the bronchoalveolar lavage fluid. 〈 i 〉 Conclusion: 〈 /i 〉 These results indicate that sex hormones play an important role in pulmonary granuloma formation by altering the Th1 responses.
    Type of Medium: Online Resource
    ISSN: 0025-7931 , 1423-0356
    URL: Article
    DOI: 10.1159/000324295
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2011
    detail.hit.zdb_id: 1464419-8
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  • 3
    Online Resource
    Online Resource
    Sex Differences in the Prevalence, Progression, and Improvement of Chronic Kidney Disease
    S. Karger AG ; 2014
    In:  Kidney and Blood Pressure Research Vol. 39, No. 4 ( 2014), p. 279-288
    Details
    In: Kidney and Blood Pressure Research, S. Karger AG, Vol. 39, No. 4 ( 2014), p. 279-288
    Abstract: 〈 b 〉 〈 i 〉 Background/Aims: 〈 /i 〉 〈 /b 〉 We examined sex differences in prevalence, progression, and improvement in early-stage chronic kidney disease (CKD). 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 We analyzed data from 533 participants who took 4 consecutive annual CKD detection tests. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Urine albumin-creatinine ratio (ACR), estimated glomerular filtration rate (eGFR), and hemoglobin (Hb) at baseline in men with and without CKD and in women with and without CKD were 8.3±6.1, 149.2±310.4, 10.2±5.8, and 96.7±246.8 mg/g Cr; 83.4±14.7, 63.8±18.8, 79.9±13.0, and 69.4±20.0 mL/min/1.73 m 〈 sup 〉 2 〈 /sup 〉 ; and 14.8±1.2, 14.3±1.4, 13.0±1.0, and 13.0±1.2 mg/dL, respectively. ACR levels decreased significantly over time in men and women with CKD and they increased significantly over time in men and women without CKD. eGFR levels in men and women with CKD did not significantly change over time, but they decreased significantly over time in men and women without CKD. CKD prevalence and progression rate were not significantly different between sexes. Among the CKD participants, significantly more women had a “cured” status at 3 years (39.1% vs. 19.4%, 〈 i 〉 P 〈 /i 〉 〈 0.01). Most whose eGFR increased to 〉 60 mL/min/1.73 m 〈 sup 〉 2 〈 /sup 〉 at 3 years had values just below those at baseline. Regression analysis showed that change in eGFR correlated significantly with ACR in men with CKD (change in eGFR = -1.707+0.022×ACR, 〈 i 〉 P 〈 /i 〉 〈 0.001, 〈 i 〉 r 〈 /i 〉 〈 sup 〉 2 〈 /sup 〉 =0.201) and with Hb and ACR in women with CKD (change in eGFR = 48.870-3.803×Hb + 0.018×ACR, 〈 i 〉 P 〈 /i 〉 〈 0.05, 〈 i 〉 r 〈 /i 〉 〈 sup 〉 2 〈 /sup 〉 =0.134). 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 These results suggest that the slight decrease of Hb within a normal range and mild anemia can be managed in women with early-stage CKD. The key baseline for eGFR is 60 mL/min/1.73 m 〈 sup 〉 2 〈 /sup 〉 .
    Type of Medium: Online Resource
    ISSN: 1420-4096 , 1423-0143
    URL: Article
    DOI: 10.1159/000355805
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2014
    detail.hit.zdb_id: 1482922-8
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  • 4
    Online Resource
    Online Resource
    〈i〉Porphyromonas gingivalis〈/i〉 Antigens and Interleukin-6 Stimulate the Production of Monocyte Chemoattractant Protein-1 via the Upregulation of Early Growth Response-1 Transcription in Human Coronary Artery Endothelial Cells
    S. Karger AG ; 2010
    In:  Journal of Vascular Research Vol. 47, No. 4 ( 2010), p. 346-354
    Details
    In: Journal of Vascular Research, S. Karger AG, Vol. 47, No. 4 ( 2010), p. 346-354
    Abstract: 〈 i 〉 Background: 〈 /i 〉 Individuals with periodontitis have elevated serum levels of IL-6 and C-reactive protein and have been reported to have a significantly increased risk of developing cardiovascular disease. The transcription factor early growth response factor 1 (Egr-1) has been shown to play an important role in the development and progression of atherosclerosis. However, it is not known whether periodontal infection affects the expression of Egr-1 and subsequent endothelial cells expression of monocyte chemoattractant protein (MCP)-1, a key molecule of leukocyte chemoattraction into vessels. 〈 i 〉 Methods: 〈 /i 〉 Human coronary artery endothelial cells (HCAECs) were stimulated with either sonicated extracts from 〈 i 〉 Porphyromonas gingivalis 〈 /i 〉 strains 381 or SU63, or a combination of IL-6 and soluble IL-6 receptor (IL-6/sIL-6R). The expression of Egr-1, and subsequently MCP-1, was then analyzed. The role of Egr-1 on MCP-1 expression was analyzed by siRNA transfection. 〈 i 〉 Results: 〈 /i 〉 Both 〈 i 〉 P. gingivalis 〈 /i 〉 antigens and IL-6/sIL-6R stimulations upregulated the expression of Egr-1, with a more robust effect by IL-6/sIL-6R. Increased expression of Egr-1 coincided with MCP-1 production, and Egr-1 downregulation by siRNA suppressed this effect. 〈 i 〉 Conclusion: 〈 /i 〉 These results clearly suggest that periodontal infection has the potential to affect HCAECs and hence contribute to the development of subsequent atherosclerosis.
    Type of Medium: Online Resource
    ISSN: 1018-1172 , 1423-0135
    URL: Article
    DOI: 10.1159/000265568
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2010
    detail.hit.zdb_id: 1482726-8
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