In:
Ophthalmic Research, S. Karger AG, Vol. 50, No. 2 ( 2013), p. 117-122
Abstract:
〈 b 〉 〈 i 〉 Purpose: 〈 /i 〉 〈 /b 〉 To investigate the association between the 〈 i 〉 CFH 〈 /i 〉 and 〈 i 〉 ARMS2 〈 /i 〉 gene polymorphisms and age-related macular degeneration (AMD) in a Brazilian cohort. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 We examined 163 individuals with AMD and 154 controls recruited at the Department of Ophthalmology of the Universidade Federal de Minas Gerais, at the Instituto da Visão, and at the Centro Especializado em Olhos, in Brazil, between 2007 and 2012. Genotyping for 〈 i 〉 CFH 〈 /i 〉 rs1061170 and 〈 i 〉 ARMS2 〈 /i 〉 rs10490924 single-nucleotide polymorphisms was performed. The odds ratios (OR) for all of the studied genotypes (heterozygous and homozygous) of both genes were calculated compared to homozygous ancestral alleles. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Homozygosity for the 〈 i 〉 CFH 〈 /i 〉 and 〈 i 〉 ARMS2 〈 /i 〉 at-risk allele was 33.3 and 23.6%, respectively, for AMD individuals and 10.3 and 7.1%, respectively, for controls (p 〈 0.0001). The OR was 7.2 (95% CI 3.6-14.5; p 〈 0.001) for the 〈 i 〉 CFH 〈 /i 〉 at-risk genotype (CC) and 5.5 (95% CI 2.6-11.8; p 〈 0.0001) for 〈 i 〉 ARMS2 〈 /i 〉 (TT). Subjects homozygous for both polymorphisms had a much higher risk of developing AMD (n = 14 patients, OR 33.3, 95% CI 12.8-86.4). The proportion of ancestry in each group indicated that AMD patients had a higher European (Caucasian) component than controls. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 〈 i 〉 CFH 〈 /i 〉 and 〈 i 〉 ARMS2 〈 /i 〉 polymorphisms were strongly associated with AMD in this Brazilian cohort.
Type of Medium:
Online Resource
ISSN:
0030-3747
,
1423-0259
Language:
English
Publisher:
S. Karger AG
Publication Date:
2013
detail.hit.zdb_id:
1483177-6
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