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  • S. Karger AG  (25)
  • 2010-2014  (25)
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  • S. Karger AG  (25)
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  • 2010-2014  (25)
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  • 1
    Online Resource
    Online Resource
    Expression of SOCS1 and SOCS3 Is Altered in the Nasal Mucosa of Patients with Mild and Moderate/Severe Persistent Allergic Rhinitis
    S. Karger AG ; 2012
    In:  International Archives of Allergy and Immunology Vol. 158, No. 4 ( 2012), p. 387-396
    Details
    In: International Archives of Allergy and Immunology, S. Karger AG, Vol. 158, No. 4 ( 2012), p. 387-396
    Abstract: 〈 i 〉 Background: 〈 /i 〉 The aim of this study was to evaluate the role of suppressor of cytokine signaling (SOCS) molecules, SOCS1 and SOCS3, which act as negative regulators of cytokine signaling in various allergic diseases, in patients with mild and moderate/severe persistent allergic rhinitis. 〈 i 〉 Methods: 〈 /i 〉 The expression and distribution pattern of SOCS1 and SOCS3 were analyzed in nasal mucosa and peripheral blood mononuclear cells (PBMC) of healthy controls, and patients with mild and moderate/severe persistent allergic rhinitis using RT-PCR, immunohistochemistry and Western blotting. IL-4, IL-13, IL-15 and IFN-γ expression was also analyzed in the nasal mucosa of each individual using RT-PCR and Western blotting. 〈 i 〉 Results: 〈 /i 〉 SOCS1 and SOCS3 mRNA and protein expression was significantly increased in the nasal mucosa and PBMC of patients with mild and moderate/severe persistent allergic rhinitis compared with healthy controls. In healthy and allergic nasal mucosa, they were commonly localized to the epithelium, submucosal glands and endothelium, showing stronger staining intensity in mild and moderate/severe persistent allergic nasal mucosa than in healthy nasal mucosa. Tissue levels of IL-4 and IL-13 were increased in moderate/severe persistent allergic nasal mucosa whereas IL-15 and IFN-γ were decreased in moderate/severe persistent allergic nasal mucosa. 〈 i 〉 Conclusions: 〈 /i 〉 Upregulation of SOCS1 and SOCS3 in mild and moderate/severe persistent allergic rhinitis suggests that SOCS proteins may be important regulators in the pathogenesis of allergic rhinitis and play a role as molecular determinants of allergic rhinitis persistence.
    Type of Medium: Online Resource
    ISSN: 1018-2438 , 1423-0097
    URL: Article
    DOI: 10.1159/000333103
    RVK:
    XA 49650
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2012
    detail.hit.zdb_id: 1482722-0
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  • 2
    Online Resource
    Online Resource
    A Prospective Comparison of Liquid-Based Cytology and Traditional Smear Cytology in Pancreatic Endoscopic Ultrasound-Guided Fine Needle Aspiration
    S. Karger AG ; 2011
    In:  Acta Cytologica Vol. 55, No. 5 ( 2011), p. 401-407
    Details
    In: Acta Cytologica, S. Karger AG, Vol. 55, No. 5 ( 2011), p. 401-407
    Abstract: 〈 i 〉 Objective: 〈 /i 〉 To compare results of liquid-based cytology (LBC) and the conventional smear method (SMEAR) when performing endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for lesions of suspected pancreatic malignancy without an on-site cytopathologist. 〈 i 〉 Study Design: 〈 /i 〉 Fifty-eight patients were prospectively enrolled between July and December 2009. Aspirates obtained from the first needle pass were randomized either to SMEAR or LBC. Another sample from the second needle pass was allocated to the other method. The rest of the aspirates from the third or later needle passes were used for SMEAR. Diagnostic accuracy was compared and related factors were pursued. 〈 i 〉 Results: 〈 /i 〉 Although both methods were 100% specific, LBC was inferior to SMEAR in terms of sensitivity, negative predictive value, and accuracy. However, LBC provided correct diagnoses in 2 out of 3 cases of false negatives for malignancy by SMEAR in which blood was highly contaminated. Although no factor was identified for LBC, low blood contamination and more than 3 needle passes were related with accurate diagnosis in SMEAR. 〈 i 〉 Conclusion: 〈 /i 〉 LBC was less accurate than SMEAR when performing pancreatic EUS-FNA without an on-site cytopathologist. However, LBC might serve as a good complement to SMEAR if blood contamination is profound.
    Type of Medium: Online Resource
    ISSN: 0001-5547 , 1938-2650
    URL: Article
    DOI: 10.1159/000330811
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2011
    detail.hit.zdb_id: 2256676-4
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    Prevalence and Predictors of Pulmonary Embolism in Korean Patients with Exacerbation of Chronic Obstructive Pulmonary Disease
    S. Karger AG ; 2013
    In:  Respiration Vol. 85, No. 3 ( 2013), p. 203-209
    Details
    In: Respiration, S. Karger AG, Vol. 85, No. 3 ( 2013), p. 203-209
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Data concerning the rate of pulmonary embolism (PE) in Asian patients with chronic obstructive pulmonary disease (COPD) exacerbation are sparse, and no study has shown predictors of PE in these patients. 〈 b 〉 〈 i 〉 Objectives: 〈 /i 〉 〈 /b 〉 The purpose of the present study was to investigate the prevalence and predictors of PE in Korean patients with COPD exacerbation. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Hospitalized patients with COPD exacerbations were prospectively enrolled into this study and underwent computed tomography (CT) pulmonary angiography and indirect CT venography. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The most common cause of COPD exacerbation was lower respiratory tract infection (82%; n = 84), followed by PE (5%; n = 5). Eight patients (8%) had venous thromboembolism, and deep vein thrombosis (DVT) was seen in 6%, with proximal DVT in 4%. On multivariate analysis, the absence of symptoms of respiratory infection and plasma D-dimer elevation (≥500 µg/l) were significant factors predicting PE in patients with COPD exacerbations (odds ratio 31, 95% confidence interval 2-563, p = 0.02, and odds ratio 25, 95% confidence interval 1-464, p = 0.03, respectively). 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 PE comprises approximately 5% of the etiologies of COPD exacerbations in Koreans. The absence of symptoms suggestive of respiratory infection and elevated plasma D-dimer levels were significant predictors of PE in this population.
    Type of Medium: Online Resource
    ISSN: 0025-7931 , 1423-0356
    URL: Article
    DOI: 10.1159/000335904
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2013
    detail.hit.zdb_id: 1464419-8
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  • 4
    Online Resource
    Online Resource
    Drain Tube-Induced Jejunal Penetration Masquerading as Bile Leak following Whipple’s Operation
    S. Karger AG ; 2011
    In:  Case Reports in Gastroenterology Vol. 5, No. 2 ( 2011), p. 295-300
    Details
    In: Case Reports in Gastroenterology, S. Karger AG, Vol. 5, No. 2 ( 2011), p. 295-300
    Type of Medium: Online Resource
    ISSN: 1662-0631
    URL: Article
    DOI: 10.1159/000329172
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2011
    detail.hit.zdb_id: 2440540-1
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  • 5
    Online Resource
    Online Resource
    Clinical Characteristics of Patients with Peripheral Pulmonary Embolism
    S. Karger AG ; 2010
    In:  Respiration Vol. 80, No. 6 ( 2010), p. 500-508
    Details
    In: Respiration, S. Karger AG, Vol. 80, No. 6 ( 2010), p. 500-508
    Abstract: 〈 i 〉 Background: 〈 /i 〉 The clinical relevance of emboli limited to the segmental or sub-segmental pulmonary arteries and the role of anticoagulation in patients with these conditions remains to be clarified. 〈 i 〉 Objectives: 〈 /i 〉 To determine the clinical characteristics and treatment outcomes of peripheral pulmonary embolism (PE), and in particular, isolated sub-segmental PE (ISSPE). 〈 i 〉 Methods: 〈 /i 〉 We reviewed the data for 334 patients who were diagnosed with a PE by computed tomographic (CT) pulmonary angiography and indirect CT venography. 〈 i 〉 Results: 〈 /i 〉 All patients were classified into one of three groups: central (245 patients, 73.4%); segmental (67 patients, 20.1%), and sub-segmental (22 patients, 6.6%). An incidental CT finding (63.6%) was the most common presentation in the segmental and sub-segmental groups. Compared with the central group, the sub-segmental group had less frequent proximal deep venous thrombosis (14 vs. 47%, Bonferroni’s corrected p = 0.002), and greater preservation of oxygenation levels (p 〈 0.05) without hemodynamic instability. The recurrence of PE and deaths related to PE did not occur in the sub-segmental group, although approximately 30% of the patients did not receive anticoagulation therapy. 〈 i 〉 Conclusions: 〈 /i 〉 Patients with ISSPE may have a more benign clinical presentation, as compared to the central type, and may follow a good clinical course without mortality or recurrence.
    Type of Medium: Online Resource
    ISSN: 0025-7931 , 1423-0356
    URL: Article
    DOI: 10.1159/000277929
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2010
    detail.hit.zdb_id: 1464419-8
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  • 6
    Online Resource
    Online Resource
    Role of Reactive Oxygen Species in Transforming Growth Factor Beta1-Induced Alpha Smooth-Muscle Actin and Collagen Production in Nasal Polyp-Derived Fibroblasts
    S. Karger AG ; 2012
    In:  International Archives of Allergy and Immunology Vol. 159, No. 3 ( 2012), p. 278-286
    Details
    In: International Archives of Allergy and Immunology, S. Karger AG, Vol. 159, No. 3 ( 2012), p. 278-286
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Myofibroblasts are detected in nasal polyps and are involved in nasal polyp formation by inducing extracellular matrix accumulation. Reactive oxygen species (ROS) are released during the differentiation of fibroblasts to myofibroblasts. The purpose of this study was to investigate ROS production and nicotinamide adenine dinucleotide phosphate oxidase (NOX) expression in nasal polyp-derived fibroblasts (NPDFs) and to evaluate whether ROS from NOX mediates transforming growth factor (TGF)-β1-induced production of alpha smooth-muscle actin (α-SMA) and collagen production. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 NPDFs were incubated and treated with TGF-β1. The mRNA expression of 〈 i 〉 NOXs, 〈 /i 〉 α 〈 i 〉 -SMA, 〈 /i 〉 and 〈 i 〉 collagen type I 〈 /i 〉 and 〈 i 〉 IV 〈 /i 〉 was determined by reverse transcription-polymerase chain reaction, and the expression of α-SMA protein was determined by immunofluorescence microscopy. The amount of total soluble collagen production was analyzed by the SirCol assay. The ROS generation of cells was investigated using the 2′,7′-dichlorfluorescein-diacetate. The fluorescence was captured by fluorescent microscope and measured using a fluorometer. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Stimulation with TGF-β1 increased ROS production by NPDFs compared with NPDFs not treated with TGF-β1. Stimulation with TGF-β1 increased the expression of 〈 i 〉 NOX4 〈 /i 〉 mRNA most potently among various Nox enzymes. 〈 i 〉 siNOX4 〈 /i 〉 was able to decrease the level of ROS production. Myofibroblast differentiation and the production of collagen in NPDFs were prevented by inhibition of ROS generation with diphenyliodonium, N-acetylcysteine, ebselen, and 〈 i 〉 siNox4 〈 /i 〉 . 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 This study showed that NOX4 and ROS have a role in myofibroblast differentiation and collagen production of TGF-β1-induced NPDFs and that these processes are inhibited by the elimination of ROS.
    Type of Medium: Online Resource
    ISSN: 1018-2438 , 1423-0097
    URL: Article
    DOI: 10.1159/000337460
    RVK:
    XA 49650
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2012
    detail.hit.zdb_id: 1482722-0
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  • 7
    Online Resource
    Online Resource
    Diverticular Choledochal Cyst with a Large Impacted Stone Masquerading as Mirizzi's Syndrome
    S. Karger AG ; 2013
    In:  Case Reports in Gastroenterology Vol. 7, No. 1 ( 2013-3-21), p. 164-168
    Details
    In: Case Reports in Gastroenterology, S. Karger AG, Vol. 7, No. 1 ( 2013-3-21), p. 164-168
    Abstract: Choledochal cysts are congenital anomalies of the biliary tract manifested by cystic dilatation of the extrahepatic and intrahepatic bile ducts. Choledochal cyst is not rare in far-East Asian countries. Type II choledochal cysts account for 2% of all such cysts. They are true diverticula of the extrahepatic bile duct and communicate with the bile duct through a narrow stalk. This condition is associated with significant complications, such as ductal strictures, stone formation, cholangitis, rupture and secondary biliary cirrhosis. We describe a case of a huge impacted stone in a diverticular choledochal cyst which masqueraded as an unusual cystic duct stone causing Mirizzi's syndrome.
    Type of Medium: Online Resource
    ISSN: 1662-0631
    URL: Article
    DOI: 10.1159/000350253
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2013
    detail.hit.zdb_id: 2440540-1
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  • 8
    Online Resource
    Online Resource
    Polymorphisms in Matrix Metalloproteinase-1, -9 and -12 Genes and the Risk of Chronic Obstructive Pulmonary Disease in a Korean Population
    S. Karger AG ; 2010
    In:  Respiration Vol. 80, No. 2 ( 2010), p. 133-138
    Details
    In: Respiration, S. Karger AG, Vol. 80, No. 2 ( 2010), p. 133-138
    Abstract: 〈 i 〉 Background: 〈 /i 〉 Although a few studies have been conducted to evaluate the association of polymorphisms in matrix metalloproteinase 〈 i 〉 (MMP) 〈 /i 〉 genes with chronic obstructive pulmonary disease (COPD), the results have been inconsistent. 〈 i 〉 Objectives: 〈 /i 〉 To investigate the association of 3 polymorphisms of 〈 i 〉 MMP 〈 /i 〉 genes ( 〈 i 〉 MMP-1 〈 /i 〉 –1607G→GG, 〈 i 〉 MMP-9 〈 /i 〉 –1562C→T and 〈 i 〉 MMP-12 〈 /i 〉 N357S), which have been reported to be associated with COPD-related phenotypes, with the risk of COPD in a Korean population. 〈 i 〉 Methods: 〈 /i 〉 The genotypes of the 3 polymorphisms were determined in 301 patients with COPD and 333 healthy controls. 〈 i 〉 Results: 〈 /i 〉 Of the 3 polymorphisms studied, only the distribution of the 〈 i 〉 MMP-9 〈 /i 〉 –1562C→T genotypes was significantly different between the cases and controls (p = 0.01), with the frequency of the variant T allele being significantly lower in the cases than in the controls (10.4 vs. 15.7%; p = 0.006). Individuals with at least 1 variant T allele were at a significantly decreased risk of COPD when compared with those with homozygous wild-type alleles (adjusted odds ratio = 0.69; 95% CI = 0.45–0.98; p = 0.04). 〈 i 〉 Conclusions: 〈 /i 〉 These findings suggest that the 〈 i 〉 MMP-9 〈 /i 〉 –1562C→T polymorphism could be used as a marker for determining the genetic susceptibility to COPD in a Korean population.
    Type of Medium: Online Resource
    ISSN: 0025-7931 , 1423-0356
    URL: Article
    DOI: 10.1159/000284926
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2010
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  • 9
    Online Resource
    Online Resource
    Successful Endoscopic Resection of Large Pedunculated Brunner's Gland Hamartoma Causing Gastrointestinal Bleeding Arising from the Pylorus
    S. Karger AG ; 2013
    In:  Case Reports in Gastroenterology Vol. 7, No. 2 ( 2013-7-18), p. 304-307
    Details
    In: Case Reports in Gastroenterology, S. Karger AG, Vol. 7, No. 2 ( 2013-7-18), p. 304-307
    Abstract: Brunner's gland hamartoma is a rare benign small bowel neoplasm and most lesions are small and asymptomatic. However, large hamartoma-related obstructive symptoms and hemorrhage related to tumor ulceration manifest as hematemesis or melena. The exact pathogenesis if these lesions is not well known, but they are thought to be frequently associated with 〈 i 〉 Helicobacter pylori 〈 /i 〉 infections and chronic pancreatitis. We report the case of a 45-year-old man who presented with melena due to a large pedunculated Brunner's gland hamartoma arising from the pylorus. It was successfully removed by endoscopic mucosal resection with piecemeal technique because of too large tumor size for application of a conventional snare.
    Type of Medium: Online Resource
    ISSN: 1662-0631
    URL: Article
    DOI: 10.1159/000354138
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2013
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  • 10
    Online Resource
    Online Resource
    Angiotensinogen Polymorphisms and Post-Transplantation Diabetes Mellitus in Korean Renal Transplant Subjects
    S. Karger AG ; 2013
    In:  Kidney and Blood Pressure Research Vol. 37, No. 2-3 ( 2013), p. 95-102
    Details
    In: Kidney and Blood Pressure Research, S. Karger AG, Vol. 37, No. 2-3 ( 2013), p. 95-102
    Abstract: 〈 b 〉 〈 i 〉 Background 〈 /i 〉 〈 /b 〉 〈 b 〉 〈 i 〉 : 〈 /i 〉 〈 /b 〉 Post-transplant diabetes mellitus (PTDM) is a common and serious metabolic complication. Genetic polymorphisms of angiotensin-converting enzyme ( 〈 i 〉 ACE 〈 /i 〉 ) and angiotensinogen ( 〈 i 〉 AGT 〈 /i 〉 ) genes have been reported to be related to diabetes mellitus and insulin sensitivity; however, the role of these genes in the development of PTDM is not known. For this purpose, we investigated the association of 〈 i 〉 ACE 〈 /i 〉 and 〈 i 〉 AGT 〈 /i 〉 genetic polymorphisms with PTDM. 〈 b 〉 〈 i 〉 Methods 〈 /i 〉 〈 /b 〉 〈 b 〉 〈 i 〉 : 〈 /i 〉 〈 /b 〉 A total of 302 subjects without previously diagnosed diabetes who had received kidney transplants were included. One 〈 i 〉 ACE 〈 /i 〉 single nucleotide polymorphism (SNP) (rs4291) and two 〈 i 〉 AGT 〈 /i 〉 SNPs (rs 699 and rs 4762) were genotyped from genomic DNA with direct sequencing. 〈 b 〉 〈 i 〉 Results 〈 /i 〉 〈 /b 〉 〈 b 〉 〈 i 〉 : 〈 /i 〉 〈 /b 〉 PTDM developed in 49 (16.2%) of 302 subjects. Subjects in the PTDM were older than those in the non-PTDM. There was a significant difference between the two groups in tacrolimus use ( 〈 i 〉 p 〈 /i 〉 =0.03). Of the three SNPs, the rs4762 of the 〈 i 〉 AGT 〈 /i 〉 gene was significantly associated with the development of PTDM in the dominant models ( 〈 i 〉 p 〈 /i 〉 = 0.03) after adjusting for age and tacrolimus usage. 〈 b 〉 〈 i 〉 Conclusions 〈 /i 〉 〈 /b 〉 〈 b 〉 〈 i 〉 : 〈 /i 〉 〈 /b 〉 〈 i 〉 AGT 〈 /i 〉 gene rs4762 polymorphisms may serve as genetic markers for the development of PTDM. The exact molecular mechanisms still need to be clarified.
    Type of Medium: Online Resource
    ISSN: 1420-4096 , 1423-0143
    URL: Article
    DOI: 10.1159/000343404
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2013
    detail.hit.zdb_id: 1482922-8
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