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  • S. Karger AG  (27)
  • 2010-2014  (27)
  • 1
    Online Resource
    Online Resource
    Clinical Characteristics and Brain Activation Patterns of Mirror Movements in Patients with Corona Radiata Infarct
    S. Karger AG ; 2010
    In:  European Neurology Vol. 64, No. 1 ( 2010), p. 15-20
    Details
    In: European Neurology, S. Karger AG, Vol. 64, No. 1 ( 2010), p. 15-20
    Abstract: 〈 i 〉 Objective: 〈 /i 〉 Mirror movements (MMs) are a phenomenon of involuntary movements that accompany physically intended movements of the opposite side of the body. In the current study, we investigated the clinical characteristics and cortical activation patterns of MMs in patients with corona radiata (CR) infarct, using functional MRI. 〈 i 〉 Subjects and Methods: 〈 /i 〉 We recruited 31 consecutive hemiparetic stroke patients with CR infarct. Functional MRI was performed to verify brain activation patterns during grasp-release movements of the affected hand, and MM of the unaffected hand was observed simultaneously. 〈 i 〉 Results: 〈 /i 〉 The prevalence of MMs was 54.8% (17 out of 31 patients), and the intensity of MMs ranged from mild to moderate. The severity of MM in the unaffected hand is closely related to the poor motor function of the affected upper extremity and to activations of the unaffected motor cortex and both supplementary motor areas (SMAs) during the movement of the affected hand. In addition, the activations of unaffected motor cortex and both SMAs were closely related to poor motor function of the affected upper extremity. 〈 i 〉 Conclusions: 〈 /i 〉 The results suggest that MMs, poor motor function, and the activations of ipsilateral motor cortex and both SMAs are closely interconnected in patients with CR infarct.
    Type of Medium: Online Resource
    ISSN: 0014-3022 , 1421-9913
    URL: Article
    DOI: 10.1159/000313979
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2010
    detail.hit.zdb_id: 1482237-4
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  • 2
    Online Resource
    Online Resource
    Clevudine Demonstrates Potent Antiviral Activity in Naïve Chronic Hepatitis B Patients
    S. Karger AG ; 2010
    In:  Intervirology Vol. 53, No. 2 ( 2010), p. 83-86
    Details
    In: Intervirology, S. Karger AG, Vol. 53, No. 2 ( 2010), p. 83-86
    Abstract: 〈 i 〉 Objectives: 〈 /i 〉 Clevudine has demonstrated antiviral potency in the treatment of naïve chronic hepatitis B patients in pivotal studies. The objectives of this study were to evaluate the safety and efficacy of a 1-year treatment with clevudine in chronic hepatitis B patients. 〈 i 〉 Methods: 〈 /i 〉 This is a post-marketing surveillance using case report forms which were submitted to the health authorities. 〈 i 〉 Results: 〈 /i 〉 Analysis of individual data showed that hepatitis B virus (HBV) DNA after a 1-year treatment was 〈 141,500 copies/ml in 96% of hepatitis B e antigen (HBeAg)-positive and 100% of HBeAg-negative patients. The proportion of patients with HBV DNA 〈 2,000 copies/ml after a 1-year treatment was 74%: 71% of HBeAg-positive and 93% of HBeAg-negative patients. Most of the patients with HBV DNA below the detection limit with each assay at week 24 showed sustained viral suppression up to week 48. The proportion of patients who showed normal alanine aminotransferase at week 48 was 86% in HBeAg-positive patients and 87% in HBeAg-negative patients. The rates of HBeAg-loss were 21%. Two patients showed viral breakthrough during treatment. 〈 i 〉 Conclusion: 〈 /i 〉 Clevudine monotherapy demonstrates potent antiviral activity as well as biochemical and serological response with a 0.7% rate of viral breakthrough in naïve chronic hepatitis B patients.
    Type of Medium: Online Resource
    ISSN: 0300-5526 , 1423-0100
    URL: Article
    DOI: 10.1159/000264197
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2010
    detail.hit.zdb_id: 1482863-7
    SSG: 12
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  • 3
    Online Resource
    Online Resource
    Improvement in Hematopoiesis after Iron Chelation Therapy with Deferasirox in Patients with Aplastic Anemia
    S. Karger AG ; 2013
    In:  Acta Haematologica Vol. 129, No. 2 ( 2013), p. 72-77
    Details
    In: Acta Haematologica, S. Karger AG, Vol. 129, No. 2 ( 2013), p. 72-77
    Abstract: Iron overload due to regular transfusions of packed red cells can cause multiple organ damage. Iron chelation therapy (ICT) is important in patients with aplastic anemia (AA) who require blood transfusions as supportive management. With the introduction of the oral iron chelator deferasirox, ICT has become more widely available and feasible. We studied 4 adult AA patients who had transfusion-induced iron overload and showed hematological improvement after ICT with oral deferasirox. Following deferasirox treatment, hemoglobin increased and serum ferritin levels decreased, and the patients subsequently became transfusion independent. Our experience raises the possibility of the potential benefit of ICT on hematopoiesis. Further long-term studies in larger patient cohorts are needed to clarify the effect of the restoration of hematopoiesis after iron chelation therapy.
    Type of Medium: Online Resource
    ISSN: 0001-5792 , 1421-9662
    URL: Article
    DOI: 10.1159/000342772
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2013
    detail.hit.zdb_id: 1481888-7
    detail.hit.zdb_id: 80008-9
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  • 4
    Online Resource
    Online Resource
    Effect of Cilostazol in Acute Lacunar Infarction Based on Pulsatility Index of Transcranial Doppler (ECLIPse): A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial
    S. Karger AG ; 2013
    In:  European Neurology Vol. 69, No. 1 ( 2013), p. 33-40
    Details
    In: European Neurology, S. Karger AG, Vol. 69, No. 1 ( 2013), p. 33-40
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 This study is intended to evaluate the propensities of cilostazol to reduce the pulsatility index (PI) in patients with acute lacunar infarction using the serial transcranial Doppler (TCD) examinations. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 In a multicenter, randomized, double-blind, placebo-controlled trial, patients were randomly assigned to receive either placebo or 100 mg cilostazol twice a day as well as aspirin 100 mg a day. The primary outcomes were the changes of middle cerebral artery (MCA) and basilar artery (BA) PIs at 14 and 90 days from the baseline TCD study. This study is registered with ClinicalTrials.gov (NCT00741286). 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Trial medication was given to 203 patients, with 100 receiving cilostazol and 103 receiving placebo, and 164 were included in the per-protocol analysis of the primary outcome. Results from the linear mixed model showed that significant effects were obtained for time-by-group interactions (p = 0.008 in right MCA, p = 0.015 in left MCA, p = 0.002 in BA), suggesting that changes of PIs from the baseline to the 90-day study were different across the groups. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 Cilostazol further decreased TCD PIs at 90 days from baseline compared to placebo in acute lacunar infarction. This result may be related to pleiotropic effects, such as vasodilation, beyond its antiplatelet activity.
    Type of Medium: Online Resource
    ISSN: 0014-3022 , 1421-9913
    URL: Article
    DOI: 10.1159/000338247
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2013
    detail.hit.zdb_id: 1482237-4
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  • 5
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    Online Resource
    Cilostazol Decreases Cerebral Arterial Pulsatility in Patients with Mild White Matter Hyperintensities: Subgroup Analysis from the Effect of Cilostazol in Acute Lacunar Infarction Based on Pulsatility Index of Transcranial Doppler (ECLIPse) Study
    S. Karger AG ; 2014
    In:  Cerebrovascular Diseases Vol. 38, No. 3 ( 2014), p. 197-203
    Details
    In: Cerebrovascular Diseases, S. Karger AG, Vol. 38, No. 3 ( 2014), p. 197-203
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 The Effect of Cilostazol in Acute Lacunar Infarction Based on Pulsatility Index of the Transcranial Doppler (ECLIPse) study showed a significant decrease in the transcranial Doppler (TCD) pulsatility index (PI) with cilostazol treatment at 90 days after acute lacunar infarction. The aim of the present study was to perform a subgroup analysis of the ECLIPse study in order to explore the effect of cilostazol in acute lacunar infarction based on cerebral white matter hyperintensities (WMH) volume. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 The ECLIPse study was a multicenter, randomized, double-blind, placebo-controlled trial that evaluated the difference between the efficacy of cilostazol and a placebo to reduce the PI in patients with acute lacunar infarction using serial TCD examinations. The primary outcome was changes in the PIs of the middle cerebral artery (MCA) and basilar artery at 14 and 90 days from the baseline TCD study. For this subgroup analysis, using semi-automated computerized software, the WMH volume was measured for those subjects for whom fluid-attenuated inversion recovery (FLAIR) images were available. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 Of the 203 patients in eight hospitals in the ECLIPse study, 130 participants from six hospitals were included in this subgroup analysis. Cilostazol was given to 63 patients (48.5%) and placebo to 67 patients (51.5%). All baseline characteristics were well balanced across the two groups, and there were no significant differences in these characteristics except in the changes of PI from the baseline to the 90-day point. There was a significant decrease of TCD PIs at 90-day study from baseline in the cilostazol group (p = 0.02). The mean WMH volume was 11.57 cm 〈 sup 〉 3 〈 /sup 〉 (0.13-68.45, median 4.86) and the mean MCA PI was 0.95 (0.62-1.50). The changes in PIs from the baseline to 14 days and to 90 days were 0.09 (-0.21 to 0.33) and 0.10 (-0.22 to 0.36). While there were no significant correlations between WMH volume and the changes in PIs, a trend of inverse correlation was observed between the WMH volume and the changes in PIs from the baseline to the 90-day point. For the subgroup analysis, the WMH volume was dichotomized based on its median value (4.90 cm 〈 sup 〉 3 〈 /sup 〉 ). Cilostazol decreased the TCD PIs significantly at the 90-day point in patients with WMH volumes ≤4.9 cm 〈 sup 〉 3 〈 /sup 〉 (p = 0.002). Significant treatment effects were observed in the cilostazol group. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 This study showed that cilostazol decreased cerebral arterial pulsatility in patients with WMH. Our findings indicate the unique effect of cilostazol in small vessel disease (SVD), especially in patients with mild WMH changes. Further clinical trials focusing on WMH volume and clinical outcomes are required to assess the unique efficacy of cilostazol in SVD.
    Type of Medium: Online Resource
    ISSN: 1015-9770 , 1421-9786
    URL: Article
    DOI: 10.1159/000365840
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2014
    detail.hit.zdb_id: 1482069-9
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  • 6
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    Reduced-Intensity Conditioning Regimen Combined with Low-Dose Total Body Irradiation in the Treatment of Myelodysplastic Syndrome
    S. Karger AG ; 2011
    In:  Acta Haematologica Vol. 126, No. 1 ( 2011), p. 21-29
    Details
    In: Acta Haematologica, S. Karger AG, Vol. 126, No. 1 ( 2011), p. 21-29
    Abstract: Although reduced-intensity conditioning (RIC) has been increasingly used in patients with myelodysplastic syndrome (MDS) to reduce transplant-related mortality, a high relapse rate in RIC remains an unresolved problem. Considering the additive antileukemic effect of low-dose total body irradiation (TBI), we evaluated the feasibility of combining RIC regimens with low-dose TBI in de novo MDS. The RIC regimen combined with low-dose TBI in this study consisted of fludarabine (150 mg/m 〈 sup 〉 2 〈 /sup 〉 ), intravenous busulfan (6.4 mg/kg), and TBI (400 cGy). Antithymocyte globulin was used to overcome HLA mismatching. A total of 31 subjects were recruited with a median age of 39 years (range 19–63). The patients received transplants from siblings (n = 20) or unrelated donors (n = 11). All patients rapidly achieved full-donor chimerism. At a median follow-up for survivors of 35 months (range 6.0–54.9), the 3-year overall survival, event-free survival, transplantation-related mortality, and relapse rates were 67.6, 63.2, 20.5 and 11.4%, respectively. The 3-year cumulative incidence of acute (grades II–IV) and chronic extensive graft-versus-host disease in patients who survived at least 100 days was 39.2 and 44.6%, respectively. These results suggest that an RIC combined with low-dose TBI may be a feasible therapeutic approach for treating de novo MDS.
    Type of Medium: Online Resource
    ISSN: 0001-5792 , 1421-9662
    URL: Article
    DOI: 10.1159/000323717
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2011
    detail.hit.zdb_id: 1481888-7
    detail.hit.zdb_id: 80008-9
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  • 7
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    Online Resource
    RANTES Polymorphisms and the Risk of Graft-versus-Host Disease in Human Leukocyte Antigen-Matched Sibling Allogeneic Hematopoietic Stem Cell Transplantation
    S. Karger AG ; 2013
    In:  Acta Haematologica Vol. 129, No. 3 ( 2013), p. 137-145
    Details
    In: Acta Haematologica, S. Karger AG, Vol. 129, No. 3 ( 2013), p. 137-145
    Abstract: We investigated the association between RANTES (regulated upon activation, normal T cell expressed and secreted) polymorphisms and clinical outcomes in patients treated with allogeneic hematopoietic stem cell transplantation (allo-HSCT). Three RANTES gene polymorphisms, i.e. –403G/A (rs2107538), –28C/G (rs2280788) and In1.1T/C (rs2280789), were genotyped, and the effects of the genotypes and haplotypes of RANTES on clinical outcomes were analyzed. The competing risk regression analysis was used to investigate the relationship between the polymorphisms and the cumulative risk of graft-versus-host disease (GVHD). An AGC haplotype in a recessive model showed significant harmful effects on the cumulative risk of acute GVHD and relapse-free survival (adjusted hazard ratios 2.42 and 2.71, 95% confidence intervals 1.29–4.55 and 1.30–5.64; p = 0.018 and 0.024, respectively), whereas a GCT haplotype did not. RANTES polymorphisms were not significantly associated with overall survival and the risk of chronic GVHD. This study suggests that RANTES polymorphisms might be associated with the occurrence of acute GVHD rather than of chronic GVHD and also of relapse-free survival in the patients treated with allo-HSCT. Further larger prospective investigations are needed to establish the role of RANTES polymorphisms in patients treated with allo-HSCT.
    Type of Medium: Online Resource
    ISSN: 0001-5792 , 1421-9662
    URL: Article
    DOI: 10.1159/000343273
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2013
    detail.hit.zdb_id: 1481888-7
    detail.hit.zdb_id: 80008-9
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  • 8
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    Proteomic Analysis Reveals an Elevated Expression of Heat Shock Protein 27 in Preeclamptic Placentas
    S. Karger AG ; 2011
    In:  Gynecologic and Obstetric Investigation Vol. 71, No. 3 ( 2011), p. 151-157
    Details
    In: Gynecologic and Obstetric Investigation, S. Karger AG, Vol. 71, No. 3 ( 2011), p. 151-157
    Abstract: 〈 i 〉 Aim: 〈 /i 〉 The purpose of this study was to identify the placental proteins that are associated with preeclampsia by performing proteomic analysis. 〈 i 〉 Methods: 〈 /i 〉 To identify the proteins associated with preeclampsia, we performed two-dimensional electrophoresis (2-DE), followed by silver staining. The overexpressed proteins were identified by performing matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF-MS), followed by peptide mass fingerprinting, a protein database search and Western blot analysis. Immunohistochemical staining was performed to determine the localization of the overexpressed Hsp27. 〈 i 〉 Results: 〈 /i 〉 By use of 2-DE and MALDI-TOF-MS analysis, twelve differentially expressed proteins were identified, of which four proteins were upregulated and eight proteins were downregulated. One of the upregulated spots was identified as Hsp27. Immunohistochemical analysis showed that Hsp27 was mainly located in the trophoblasts. The Western blot analysis showed that the expression of Hsp27 in the tissues of the preeclampsia placenta was significantly increased. 〈 i 〉 Conclusions: 〈 /i 〉 Our study confirmed that four proteins are upregulated and eight proteins are downregulated in preeclampsia. These differentially expressed proteins include signal transduction protein and molecular chaperon protein, in which Hsp27 is upregulated. We suggest that the increased expression level of Hsp27 might be correlated with the pathophysiology of preeclampsia.
    Type of Medium: Online Resource
    ISSN: 0378-7346 , 1423-002X
    URL: Article
    DOI: 10.1159/000315162
    RVK:
    XA 45603
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2011
    detail.hit.zdb_id: 1482695-1
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  • 9
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    HLA-DRB1*010101 Allele Is Closely Associated with Poor Virological Response to Lamivudine Therapy in Patients with Chronic Hepatitis B
    S. Karger AG ; 2011
    In:  Digestion Vol. 84, No. Suppl. 1 ( 2011), p. 35-42
    Details
    In: Digestion, S. Karger AG, Vol. 84, No. Suppl. 1 ( 2011), p. 35-42
    Abstract: 〈 i 〉 Background/Aims: 〈 /i 〉 We intended to evaluate the association between specific human leukocyte antigen (HLA)-DRB1 gene polymorphism and antiviral response to lamivudine (LAM) therapy in chronic hepatitis B (CHB) patients. 〈 i 〉 Methods: 〈 /i 〉 Six-digit HLA-DRB1 genotypes were determined using sequence-based typing in 334 CHB patients initially treated with LAM for at least 12 months. Antiviral response was evaluated every 3–6 months during LAM therapy. 〈 i 〉 Results: 〈 /i 〉 Median age of the subjects was 43 years (range, 16–72). Median duration of LAM therapy was 69 months (range, 13–140). Median baseline serum hepatitis B virus (HBV DNA) level was 7.0 log 〈 sub 〉 10 〈 /sub 〉 copies/ml (range, 5.5–9.1). At 12 months of LAM therapy, serum HBV DNA was undetectable by solution hybridization method in 308 (88%) patients. Among 25 HLA-DRB1 alleles identified, HLA-DRB1*090102, *080302, and *070101 were the most frequent alleles ( 〉 10%). HLA-DRB1*010101 was identified in 5.4% (18/334). The frequency of the HLA-DRB1*010101 allele was significantly lower in patients with virological response at 12 months of LAM therapy than in patients without it (4.2 vs. 19.2%, p = 0.025). The other HLA-DRB1 alleles were not associated with virological response. HBeAg loss/seroconversion and alanine aminotransferase normalization were not associated with HLA-DRB1 alleles. 〈 i 〉 Conclusion: 〈 /i 〉 The HLA-DRB1*010101 allele is closely associated with poor virological response to initial LAM therapy in CHB patients.
    Type of Medium: Online Resource
    ISSN: 0012-2823 , 1421-9867
    URL: Article
    DOI: 10.1159/000333783
    RVK:
    XA 40650
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2011
    detail.hit.zdb_id: 1482218-0
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  • 10
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    Polymorphisms near 〈b〉〈i〉Interleukin 28B〈/i〉〈/b〉 Gene Are Not Associated with Hepatitis B Virus Clearance, Hepatitis B e Antigen Clearance and Hepatocellular Carcinoma Occurrence
    S. Karger AG ; 2013
    In:  Intervirology Vol. 56, No. 2 ( 2013), p. 84-90
    Details
    In: Intervirology, S. Karger AG, Vol. 56, No. 2 ( 2013), p. 84-90
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Polymorphisms near the 〈 i 〉 IL28B 〈 /i 〉 gene have been proposed to be strongly associated with treatment response and the rate of spontaneous clearance of hepatitis C virus infection, and treatment response of hepatitis B virus (HBV) infection. In this study, we aimed to determine whether these polymorphisms could affect natural courses of HBV infection. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Genetic variations were identified through direct DNA sequencing using TaqMan assay in 1,439 patients with past or present HBV infection. Subjects included 404 spontaneously recovered patients, 313 chronic hepatitis B (CHB) patients, 305 liver cirrhosis (LC) patients and 417 hepatocellular carcinoma (HCC) patients. Three polymorphisms near the 〈 i 〉 IL28B 〈 /i 〉 gene, rs8099917T 〉 G, rs12979860C 〉 T and rs12980275A 〉 G, were identified. Associations between these polymorphisms and HBV clearance, hepatitis B e antigen (HBeAg) clearance as well as HCC occurrence among patients were analyzed using logistic regression analyses adjusted for age and gender. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 There were no significant associations between these polymorphisms and the HBV clearance both in CHB and LC groups. Similarly, these polymorphisms showed no significant associations with HBeAg clearance and the occurrence of HCC either. 〈 b 〉 〈 i 〉 Discussion: 〈 /i 〉 〈 /b 〉 No significant association was identified between polymorphisms near the 〈 i 〉 IL28B 〈 /i 〉 gene and the natural courses of chronic HBV infection, including the HBV clearance and HCC occurrence.
    Type of Medium: Online Resource
    ISSN: 0300-5526 , 1423-0100
    URL: Article
    DOI: 10.1159/000342526
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2013
    detail.hit.zdb_id: 1482863-7
    SSG: 12
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