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  • S. Karger AG  (16)
  • 2010-2014  (16)
  • 1
    Online Resource
    Online Resource
    Antioxidants in Asian-Korean and Caucasian Skin: The Influence of Nutrition and Stress
    S. Karger AG ; 2014
    In:  Skin Pharmacology and Physiology Vol. 27, No. 6 ( 2014), p. 293-302
    Details
    In: Skin Pharmacology and Physiology, S. Karger AG, Vol. 27, No. 6 ( 2014), p. 293-302
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 The antioxidant status of the human skin provides protection against the destructive action of free radicals. Most antioxidants cannot be synthesized by the human organism itself, but have to be ingested with a healthy nutrition rich in fruit and vegetables. The Korean cuisine is known to be one of the healthiest worldwide. This binational study investigated the cutaneous carotenoid concentrations in German subjects, South Korean subjects and immigrant Korean subjects resident in Germany and examined whether dietary- and lifestyle-related differences are reflected in the cutaneous carotenoid concentrations. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Measurements of the carotenoid concentrations of 714 healthy volunteers were performed using a non-invasive spectroscopic measurement system based on reflectance spectroscopy. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 In the present study South Korean residents showed a significantly higher antioxidant status than both native German residents and Korean immigrants living in Germany (p 〈 0.001). The first generation of Korean immigrants to Germany over the age of 50 mostly preserved Korean dietary habits, showing significantly higher concentrations (p 〈 0.001) than the German-born second and third Korean generations under the age of 50. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 The results of the study indicate that a healthy nutrition alone does not provide a high antioxidant status unless the stress exposure can be reduced simultaneously.
    Type of Medium: Online Resource
    ISSN: 1660-5527 , 1660-5535
    URL: Article
    DOI: 10.1159/000361053
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2014
    detail.hit.zdb_id: 1483572-1
    detail.hit.zdb_id: 2131931-5
    SSG: 15,3
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  • 2
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    Clinical Significance of Chronic Kidney Disease and Atrial Fibrillation on Morbidity and Mortality in Patients with Acute Myocardial Infarction
    S. Karger AG ; 2014
    In:  American Journal of Nephrology Vol. 40, No. 4 ( 2014), p. 345-352
    Details
    In: American Journal of Nephrology, S. Karger AG, Vol. 40, No. 4 ( 2014), p. 345-352
    Abstract: 〈 b 〉 〈 i 〉 Background/Aims: 〈 /i 〉 〈 /b 〉 Atrial fibrillation (AF) often coexists with acute myocardial infarction (AMI), and chronic kidney disease (CKD) is a major risk for AMI. However, the combined impact of CKD and AF on the mortality and morbidity in AMI population has not been determined. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Between January 2004 and December 2009, a total of 4,738 AMI patients were enrolled prospectively. Patients were divided into four groups according to the combined status of CKD and AF. The primary endpoint was a combination of 5-year major adverse cardiac and cerebrovascular events (MACCE). 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The prevalence of AF was significantly higher in CKD patients than in non-CKD patients (6.76 vs. 3.31%, p 〈 0.001). The highest cumulative event rate of MACCE and death was observed in patients with both CKD and AF (68.5 and 64.0%), respectively. In multivariable analyses, compared with patients with neither AF nor CKD, hazard ratios (HR) for composite of MACCE were 1.66 (95% CI, 1.14-2.41), 1.24 (95% CI, 1.06-1.46), and 2.10 (95% CI, 1.42-3.13) for patients with AF only, those with CKD only, and those with both CKD and AF, respectively (p for interaction = 0.935). Patients with both CKD and AF had a greatest risk for all-cause mortality (HR 2.54; 95% CI, 1.60-4.53), and the significant synergistic interaction was observed between CKD and AF (p for interaction = 0.015). 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 The combined effect of AF and CKD on the risk of MACCE after an AMI is stronger than any separate condition, and it confers a synergistic effect on the all-cause mortality risk.
    Type of Medium: Online Resource
    ISSN: 0250-8095 , 1421-9670
    URL: Article
    DOI: 10.1159/000368422
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2014
    detail.hit.zdb_id: 604540-6
    detail.hit.zdb_id: 1468523-1
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  • 3
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    Intraoperative Facial Electromyography and Brainstem Auditory Evoked Potential Findings in Microvascular Decompression for Hemifacial Spasm: Correlation with Postoperative Delayed Facial Palsy
    S. Karger AG ; 2012
    In:  Stereotactic and Functional Neurosurgery Vol. 90, No. 4 ( 2012), p. 260-265
    Details
    In: Stereotactic and Functional Neurosurgery, S. Karger AG, Vol. 90, No. 4 ( 2012), p. 260-265
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 Delayed facial palsy (DFP) after microvascular decompression (MVD) in patients with hemifacial spasm (HFS) is not uncommon, but the cause remains unknown. 〈 b 〉 〈 i 〉 Objectives: 〈 /i 〉 〈 /b 〉 To assess whether intraoperative electromyography (EMG) and brainstem auditory evoked potential (BAEP) can predict DFP after MVD. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 Between September 2009 and February 2011 we examined 86 patients, 9 of whom (10.4%) developed DFP after MVD on the same side. All patients underwent MVD and were followed-up for a median period of 13 months (range 6–22). We retrospectively examined intraoperative facial EMG and BAEP findings using our MVD patients’ registry. We excluded secondary HFS and immediate postoperative facial palsy after MVD in this study. We assessed the prevalence and clinical characteristics of DFP and compared EMG and BAEP findings between DFP and non-DFP groups. 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 All patients recovered completely, with a mean time to recovery of 37.8 days (range 22–57). There were no significant differences between DFP and non-DFP patients in terms of the amplitude and latency of intraoperative EMG and BAEP. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 The usefulness of intraoperative facial EMG and BAEP is limited and cannot predict DFP after MVD for HFS. We speculate that DFP after MVD is not associated with permanent nerve damage according to the EMG findings.
    Type of Medium: Online Resource
    ISSN: 1011-6125 , 1423-0372
    URL: Article
    DOI: 10.1159/000338685
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2012
    detail.hit.zdb_id: 645069-6
    detail.hit.zdb_id: 1483576-9
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  • 4
    Online Resource
    Online Resource
    Clinical Significance of Early-Onset Hyperuricemia in Renal Transplant Recipients
    S. Karger AG ; 2010
    In:  Nephron Clinical Practice Vol. 117, No. 3 ( 2010-9-17), p. c276-c283
    Details
    In: Nephron Clinical Practice, S. Karger AG, Vol. 117, No. 3 ( 2010-9-17), p. c276-c283
    Abstract: 〈 i 〉 Background/Aims: 〈 /i 〉 It is undetermined whether the effect of uric acid (UA) on graft outcome is independent of graft dysfunction. This study was designed to explore whether early-onset hyperuricemia has clinical significance regardless of graft function. 〈 i 〉 Methods: 〈 /i 〉 This study was conducted based on a retrospective chart review. We calculated time-averaged UA and estimated glomerular filtration rate from the values at 3, 6, and 9 months after transplantation. Cardiovascular complications during follow-up and long-term graft survival were assessed according to UA levels and graft function. 〈 i 〉 Results: 〈 /i 〉 351 patients were enrolled into this study. Hyperuricemia increased the risk of cardiovascular complications (HR = 2.8, 95% CI 1.1–7.1; p = 0.02), but reduced graft function did not. In the hyperuricemia group, 5- and 10-year graft survival was significantly lower than in the normouricemia group (89 and 81% vs. 96 and 92%, respectively; p = 0.02). In the reduced graft function group, these values were also lower than in the normal graft function group (89 and 81% vs. 96 and 93%, respectively; p = 0.02). In the multivariate analysis, both hyperuricemia and reduced graft function were independent risk factors for graft failure and the presence of both factors presented the highest risk. 〈 i 〉 Conclusion: 〈 /i 〉 Early-onset hyperuricemia is a significant predictor of cardiovascular complications and graft survival independently of graft function.
    Type of Medium: Online Resource
    ISSN: 1660-2110
    URL: Article
    DOI: 10.1159/000320743
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2010
    detail.hit.zdb_id: 2098336-0
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  • 5
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    Autologous Collagen-Induced Chondrogenesis Using Fibrin and Atelocollagen Mixture
    S. Karger AG ; 2013
    In:  Cells Tissues Organs Vol. 198, No. 4 ( 2013), p. 278-288
    Details
    In: Cells Tissues Organs, S. Karger AG, Vol. 198, No. 4 ( 2013), p. 278-288
    Abstract: For articular cartilage defect treatment, many treatment modalities have been developed. We evaluate the cartilage repair potential of an atelocollagen and fibrin mixture transplanted to cartilage defects. A circular, articular cartilage defect 4 mm in diameter was made in the trochlear region in each of 20 New Zealand white rabbits. The 10 rabbits in the control group were kept without treatment and the 10 rabbits in the experimental group underwent injection of atelocollagen mixed with fibrin. At week 12 following surgery the cartilage was observed and histologically compared in both groups. The surface of the newly generated cartilage was very smooth and even, and we also noted that the entire area was completely regenerated in the experimental group. The control group showed incomplete and irregular cartilage formation in the defect. Regarding the histological scoring, comparison of the two groups differed significantly (p 〈 0.001). Injection of a mixture of atelocollagen and fibrin used to treat articular cartilage defects of the knee appears to be an effective method for cartilage regeneration.
    Type of Medium: Online Resource
    ISSN: 1422-6405 , 1422-6421
    URL: Article
    DOI: 10.1159/000356488
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2013
    detail.hit.zdb_id: 1481840-1
    detail.hit.zdb_id: 1468141-9
    SSG: 12
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  • 6
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    Moyamoya Syndrome after Radiation Therapy: Case Reports
    S. Karger AG ; 2011
    In:  Pediatric Neurosurgery Vol. 47, No. 2 ( 2011), p. 138-142
    Details
    In: Pediatric Neurosurgery, S. Karger AG, Vol. 47, No. 2 ( 2011), p. 138-142
    Abstract: Potentially harmful effects of irradiation on the developing central nervous system have been well documented. We report 2 pediatric patients with moyamoya syndrome developed after irradiation. 〈 i 〉 Case: 〈 /i 〉 A 3-year-old girl had received 4,860 cGy of postoperative radiation for optic pathway glioma. Cerebral angiography 7 months after completion of the radiation therapy revealed progressive cerebral arterial occlusive disease, involving the internal carotid artery on either side of the circle of Willis, with abnormal netlike vessels. Another 5-year-old girl had received 3,600 cGy of postoperative radiation on the cerebrum for a medulloblastoma. Two years later, she was diagnosed with moyamoya syndrome and treated with indirect revascularization. She died due to further progressive obstruction of the right M1 and A1 on the unoperated hemisphere, in spite of well-developed collateral circulation from the superficial temporal artery and middle meningeal artery on the operated left hemisphere. We suggest that radiation therapy with portals typically including carotid siphon may particularly cause vascular damage, regardless of the tumor pathology and lead to radiation-induced moyamoya syndrome. The prognosis may be poorer in case of poor collateral flow and rapid progression. The radiation therapy may cause fatal vascular damage so it should be taken into consideration when a treatment plan is being formulated for young patients.
    Type of Medium: Online Resource
    ISSN: 1016-2291 , 1423-0305
    URL: Article
    DOI: 10.1159/000330541
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2011
    detail.hit.zdb_id: 1483546-0
    detail.hit.zdb_id: 1091757-3
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  • 7
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    Can High-Sensitivity C-Reactive Protein and Plasma Homocysteine Levels Independently Predict the Prognosis of Patients with Functional Disability after First-Ever Ischemic Stroke?
    S. Karger AG ; 2010
    In:  European Neurology Vol. 64, No. 5 ( 2010), p. 304-310
    Details
    In: European Neurology, S. Karger AG, Vol. 64, No. 5 ( 2010), p. 304-310
    Abstract: 〈 i 〉 Background: 〈 /i 〉 The prognosis of functional disability in patients with cerebrovascular disease has not been well established. Therefore, we conducted this study to determine the prognostic significance of high-sensitivity C-reactive protein (hs-CRP) and homocysteine (Hcy) levels in patients with functional disability after acute first-ever ischemic stroke. 〈 i 〉 Method: 〈 /i 〉 A total of 309 patients with first-ever stroke were examined within 24 h after symptom onset. Hcy was measured at admission, and hs-CRP measurements were made at admission and on the seventh hospital day. The correlations between the concentration of hs-CRP or Hcy and functional disability at 1, 3, 6 and 12 months after stroke onset were analyzed. 〈 i 〉 Results: 〈 /i 〉 The present study showed that both hs-CRP values on admission and on the seventh hospital day were significantly correlated with modified Rankin Scale (mRS) scores obtained at 4 times after the onset of stroke. These results also demonstrated that mRS scores are more closely associated with hs-CRP values on the seventh hospital day than on admission. However, there was no significant relationship between Hcy and mRS scores during the 12-month follow-up period. 〈 i 〉 Conclusion: 〈 /i 〉 According to the present study, we cautiously suggest that hs-CRP values on the subacute phase have sufficient value as a predictor of the prognosis of functional disability after first-ever stroke.
    Type of Medium: Online Resource
    ISSN: 0014-3022 , 1421-9913
    URL: Article
    DOI: 10.1159/000321415
    RVK:
    XA 10000
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2010
    detail.hit.zdb_id: 209426-5
    detail.hit.zdb_id: 1482237-4
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  • 8
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    Infectious Risks and Optimal Strength of Maintenance Immunosuppressants in Rituximab-Treated Kidney Transplantation
    S. Karger AG ; 2012
    In:  Nephron Extra Vol. 2, No. 1 ( 2012-3-28), p. 66-75
    Details
    In: Nephron Extra, S. Karger AG, Vol. 2, No. 1 ( 2012-3-28), p. 66-75
    Abstract: 〈 i 〉 Background: 〈 /i 〉 Rituximab, an anti-CD20 antibody, effectively depletes B lymphocytes. It is not clear whether the use of conventional doses of mycophenolate mofetil (MMF), methylprednisolone and tacrolimus as maintenance immunosuppression in rituximab-treated kidney transplantation is associated with increased risk. 〈 i 〉 Methods: 〈 /i 〉 We retrospectively evaluated 67 patients who underwent HLA-sensitized or ABO-incompatible living donor kidney transplantation after one dose of rituximab (200 or 500 mg) (group 1). Eighty-seven kidney transplant recipients who did not require rituximab served as a control (group 2). 〈 i 〉 Results: 〈 /i 〉 Cytomegalovirus infection (16.4 vs. 5.7%, p = 0.031) and pneumonia (9.0 vs. 1.1%, p = 0.043) occurred more often in group 1, and 2 patients of group 1 died of infection. The doses of methylprednisolone and tacrolimus levels of the two groups were not different. MMF dose was reduced when serious infection occurred. The doses of MMF (in grams/day) at the following times postoperatively were lower in group 1 than in group 2: 1 month: 1.26 ± 0.42 vs. 1.40 ± 0.39, p = 0.033; 3 months: 1.14 ± 0.51 vs. 1.36 ± 0.39, p = 0.011; 6 months: 1.07 ± 0.50 vs. 1.30 ± 0.42, p = 0.012; 1 year: 0.88 ± 0.52 vs. 1.19 ± 0.44, p = 0.009; 2 years: 0.69 ± 0.55 vs. 1.25 ± 0.49, p = 0.059, but the reduction of MMF doses did not increase the incidence of acute rejection in group 1 (4.5% in group 1 vs. 9.2% in group 2, p = 0.351). If patients who died with functioning graft were excluded, graft survival was 98.5% in group 1 and 100% in group 2. 〈 i 〉 Conclusions: 〈 /i 〉 Serious infectious complications were increased in rituximab-treated kidney transplant recipients and it might be adequate to reduce the MMF dose from the early postoperative period.
    Type of Medium: Online Resource
    ISSN: 1664-5529
    URL: Article
    DOI: 10.1159/000337339
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2012
    detail.hit.zdb_id: 2658188-7
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  • 9
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    Midbrain Hypometabolism in Fatal Familial Insomnia: A Case Report and a Statistical Parametric Mapping Analysis of a Korean Family
    S. Karger AG ; 2014
    In:  Case Reports in Neurology Vol. 6, No. 3 ( 2014-10-30), p. 243-250
    Details
    In: Case Reports in Neurology, S. Karger AG, Vol. 6, No. 3 ( 2014-10-30), p. 243-250
    Abstract: 〈 b 〉 〈 i 〉 Background and Methods: 〈 /i 〉 〈 /b 〉 Fatal familial insomnia (FFI) is a rare genetic disease characterized by intractable insomnia, dysautonomia, and dementia. Herein we describe a patient with FFI. In order to study brain glucose hypometabolism in the patient, we used statistical parametric mapping (SPM) analysis of [ 〈 sup 〉 18 〈 /sup 〉 F]-fluorodeoxyglucose positron emission tomography (FDG-PET). 〈 b 〉 〈 i 〉 Case Report: 〈 /i 〉 〈 /b 〉 The patient was a 34-year-old Korean man. He presented with intractable insomnia, rapidly progressive dementia and autonomic disturbances. A comprehensive clinical investigation was conducted, including brain MRI, electroencephalography, polysomnography, neuropsychological tests, FDG-PET and genomic tests. SPM analysis was performed using 7 healthy controls. Direct sequencing of the 〈 i 〉 PRNP 〈 /i 〉 gene identified a heterozygous p.Asp179Asn mutation homozygous for methionine at codon 129 and for glutamate at codon 219. The results of the SPM analysis showed marked hypometabolism in the deep cerebral nuclei (including the bilateral thalami, caudate nuclei, and hypothalamus), association cortices (including the frontal, lateral temporal, inferior parietal lobule and posterior cingulate gyri), and midbrain. 〈 b 〉 〈 i 〉 Conclusions: 〈 /i 〉 〈 /b 〉 This is the first Korean report of FFI, in which the family showed male phenotypic predominance. The patient's SPM analysis demonstrated brain hypometabolism in the midbrain and the hypothalamus, as well as the thalami, caudate nuclei, and multiple cortical regions. These results contribute further to the overall understanding of the pathophysiology of FFI.
    Type of Medium: Online Resource
    ISSN: 1662-680X
    URL: Article
    DOI: 10.1159/000365412
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2014
    detail.hit.zdb_id: 2505302-4
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  • 10
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    Angiotensinogen Polymorphisms and Post-Transplantation Diabetes Mellitus in Korean Renal Transplant Subjects
    S. Karger AG ; 2013
    In:  Kidney and Blood Pressure Research Vol. 37, No. 2-3 ( 2013), p. 95-102
    Details
    In: Kidney and Blood Pressure Research, S. Karger AG, Vol. 37, No. 2-3 ( 2013), p. 95-102
    Abstract: 〈 b 〉 〈 i 〉 Background 〈 /i 〉 〈 /b 〉 〈 b 〉 〈 i 〉 : 〈 /i 〉 〈 /b 〉 Post-transplant diabetes mellitus (PTDM) is a common and serious metabolic complication. Genetic polymorphisms of angiotensin-converting enzyme ( 〈 i 〉 ACE 〈 /i 〉 ) and angiotensinogen ( 〈 i 〉 AGT 〈 /i 〉 ) genes have been reported to be related to diabetes mellitus and insulin sensitivity; however, the role of these genes in the development of PTDM is not known. For this purpose, we investigated the association of 〈 i 〉 ACE 〈 /i 〉 and 〈 i 〉 AGT 〈 /i 〉 genetic polymorphisms with PTDM. 〈 b 〉 〈 i 〉 Methods 〈 /i 〉 〈 /b 〉 〈 b 〉 〈 i 〉 : 〈 /i 〉 〈 /b 〉 A total of 302 subjects without previously diagnosed diabetes who had received kidney transplants were included. One 〈 i 〉 ACE 〈 /i 〉 single nucleotide polymorphism (SNP) (rs4291) and two 〈 i 〉 AGT 〈 /i 〉 SNPs (rs 699 and rs 4762) were genotyped from genomic DNA with direct sequencing. 〈 b 〉 〈 i 〉 Results 〈 /i 〉 〈 /b 〉 〈 b 〉 〈 i 〉 : 〈 /i 〉 〈 /b 〉 PTDM developed in 49 (16.2%) of 302 subjects. Subjects in the PTDM were older than those in the non-PTDM. There was a significant difference between the two groups in tacrolimus use ( 〈 i 〉 p 〈 /i 〉 =0.03). Of the three SNPs, the rs4762 of the 〈 i 〉 AGT 〈 /i 〉 gene was significantly associated with the development of PTDM in the dominant models ( 〈 i 〉 p 〈 /i 〉 = 0.03) after adjusting for age and tacrolimus usage. 〈 b 〉 〈 i 〉 Conclusions 〈 /i 〉 〈 /b 〉 〈 b 〉 〈 i 〉 : 〈 /i 〉 〈 /b 〉 〈 i 〉 AGT 〈 /i 〉 gene rs4762 polymorphisms may serve as genetic markers for the development of PTDM. The exact molecular mechanisms still need to be clarified.
    Type of Medium: Online Resource
    ISSN: 1420-4096 , 1423-0143
    URL: Article
    DOI: 10.1159/000343404
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2013
    detail.hit.zdb_id: 1482922-8
    detail.hit.zdb_id: 1326018-2
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