GLORIA

GEOMAR Library Ocean Research Information Access

feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • PANGAEA  (156)
  • The American Society for Biochemistry and Molecular Biology (ASBMB)
  • 2010-2014  (157)
Document type
Keywords
Years
Year
  • 1
    Publication Date: 2013-09-21
    Description: In eukaryotic organisms, cysteine palmitoylation is an important reversible modification that impacts protein targeting, folding, stability, and interactions with partners. Evidence suggests that protein palmitoylation contributes to key biological processes in Apicomplexa with the recent palmitome of the malaria parasite Plasmodium falciparum reporting over 400 substrates that are modified with palmitate by a broad range of protein S-acyl transferases. Dynamic palmitoylation cycles require the action of an acyl-protein thioesterase (APT) that cleaves palmitate from substrates and conveys reversibility to this posttranslational modification. In this work, we identified candidates for APT activity in Toxoplasma gondii. Treatment of parasites with low micromolar concentrations of β-lactone- or triazole urea-based inhibitors that target human APT1 showed varied detrimental effects at multiple steps of the parasite lytic cycle. The use of an activity-based probe in combination with these inhibitors revealed the existence of several serine hydrolases that are targeted by APT1 inhibitors. The active serine hydrolase, TgASH1, identified as the homologue closest to human APT1 and APT2, was characterized further. Biochemical analysis of TgASH1 indicated that this enzyme cleaves substrates with a specificity similar to APTs, and homology modeling points toward an APT-like enzyme. TgASH1 is dispensable for parasite survival, which indicates that the severe effects observed with the β-lactone inhibitors are caused by the inhibition of non-TgASH1 targets. Other ASH candidates for APT activity were functionally characterized, and one of them was found to be resistant to gene disruption due to the potential essential nature of the protein.
    Print ISSN: 0021-9258
    Electronic ISSN: 1083-351X
    Topics: Biology , Chemistry and Pharmacology
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 2
    Publication Date: 2014-04-30
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
    Format: application/pdf
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 3
    Publication Date: 2019-07-17
    Repository Name: EPIC Alfred Wegener Institut
    Type: PANGAEA Documentation , notRev
    Format: application/pdf
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 4
    Publication Date: 2023-05-12
    Description: The Vernagtferner region has a long tradition of glaciological research performed by groups from Munich. It started in 1889, when Prof. Sebastian Finsterwalder from the Technical University in Munich produced the first map of a complete glacier based on terrestrial photogrammetry. Since then, numerous maps of the glacier have been made, describing the change in surface elevation for more than a century. These maps form the basis of the geodetic method of glacier mass balance determination, which provides volume changes as average data for the period between two surveys, i.e. typically for 10 years. Since the start of the glaciological method on Vernagtferner in 1964, annual as well as winter and summer mass balance data are available continuously. But only since 1973, the construction of the Vernagtbach station, approximately 1 km below the glacier margin at that time, provided the means to record a larger number of hydrological and meteorological parameters with a temporal resolution of typically 1 hour.
    Keywords: Glaciers Austria; Pegelstation_Vernagtbach; Pegelstation_Vernagtbach_meteorology; UGS; Unmanned gauge station; Unmanned weather station/meteorological observation; UWST; Vernagtferner, Ötztaler Alpen, Austria
    Type: Dataset
    Format: application/zip, 87 datasets
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 5
    Publication Date: 2023-01-13
    Description: In November 2001, two separate Campbell loggers ("Meteologger" and "Hydrologger", both type CR23X) were installed at the Vernagtbach site in the Oetztal Alps, Austria (Latitude: 46.85; Longitude: 10.82; Elevation: 2640 m). On these loggers, 10-minutes centred averages for the meteorological data and 5-minutes centred averages for the hydrological data are recorded. The meteorological parameters comprise air temperature, humidity of the air, air pressure, four radiation components, wind direction and speed, precipitation and snow height. For air temperature, two records are published, recorded with a ventilated and an unventilated Pt-100 in a Stevenson screen; for precipitation, three time series are available: (I) the cumulative record of a weighing gauge for the whole year, (II) single events derived from (I), and (III) single events from a tipping bucket; (II) and (III) are only provided for the period 1, May to 31, October of each year. Wind records are also given with a time step of one hour, as only these records include several statistics of speed and direction. Hydrological parameters are recorded on the "Hydrologger", they comprise water stage, discharge, water temperature and electrolytic conductivity of the water. An identifying number gives the kind of instrument used in the water stage time series. Daily photographs of the glacier are provided and analysed with respect to precipitation type.
    Type: Dataset
    Format: application/zip, 46 datasets
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 6
    Publication Date: 2023-01-13
    Description: The first meteorological station in the Vernagtferner basin, called 'Gletschermitte' was run from 1968 to 1987. It was positioned on a small rock in the western part of the glacier at an elevation of 3078 m a.s.l. The coordinates were 46.868939° N (Latitude) and 10.802986° E (Longitude). The following parameters were recorded mainly during the summer months: Wind speed and wind direction, air temperature and humidity of the air and precipitation. The records of the first four parameters comprise hourly values from 1968 to 1986 /1987, daily sums of precipitation run from 1977 to 1987. All quantities were recorded on paper chart, i.e. 'Woelfle-Windschreiber' for the wind components, mechanically driven thermo-hygrographs (1968 to 1975) and 'BTW-Langzeit-Thermo-Hygrograph' (1977 to 1987) for temperature and humidity, Belfort analogue weighing gauge for precipitation. In 1976, air temperature was recorded on a Schenk paper chart recorder. In addition, photographs of the eastern part of Vernagtferner were taken once a day in summer between 1981 and 1986.
    Type: Dataset
    Format: application/zip, 20 datasets
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 7
    Publication Date: 2023-01-13
    Keywords: Anemometer, Wölfle; DATE/TIME; HEIGHT above ground; Temperature, air; Thermograph, Wilhelm Lambrecht; Unmanned weather station/meteorological observation; UWST; Vernagtferner_Gletschermitte; Vernagtferner, Ötztaler Alpen, Austria; Wind direction; Wind speed
    Type: Dataset
    Format: text/tab-separated-values, 3997 data points
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 8
    Publication Date: 2023-01-13
    Keywords: Anemometer, Wölfle; DATE/TIME; HEIGHT above ground; Temperature, air; Thermograph, Wilhelm Lambrecht; Unmanned weather station/meteorological observation; UWST; Vernagtferner_Gletschermitte; Vernagtferner, Ötztaler Alpen, Austria; Wind direction; Wind speed
    Type: Dataset
    Format: text/tab-separated-values, 6281 data points
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 9
    Publication Date: 2023-01-13
    Keywords: Anemometer, Wölfle; DATE/TIME; HEIGHT above ground; Temperature, air; Thermograph, Wilhelm Lambrecht; Unmanned weather station/meteorological observation; UWST; Vernagtferner_Gletschermitte; Vernagtferner, Ötztaler Alpen, Austria; Wind direction; Wind speed
    Type: Dataset
    Format: text/tab-separated-values, 10501 data points
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
  • 10
    Publication Date: 2023-01-13
    Keywords: Anemometer, Wölfle; DATE/TIME; HEIGHT above ground; Temperature, air; Thermograph, Wilhelm Lambrecht; Unmanned weather station/meteorological observation; UWST; Vernagtferner_Gletschermitte; Vernagtferner, Ötztaler Alpen, Austria; Wind direction; Wind speed
    Type: Dataset
    Format: text/tab-separated-values, 5954 data points
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...