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  • Ovid Technologies (Wolters Kluwer Health)  (3)
  • 2010-2014  (3)
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  • Ovid Technologies (Wolters Kluwer Health)  (3)
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  • 2010-2014  (3)
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  • 1
    Online Resource
    Online Resource
    Ovid Technologies (Wolters Kluwer Health) ; 2012
    In:  Journal of the American Society of Nephrology Vol. 23, No. 8 ( 2012-08), p. 1364-1374
    In: Journal of the American Society of Nephrology, Ovid Technologies (Wolters Kluwer Health), Vol. 23, No. 8 ( 2012-08), p. 1364-1374
    Type of Medium: Online Resource
    ISSN: 1046-6673
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2012
    detail.hit.zdb_id: 2092588-8
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  • 2
    In: Stroke, Ovid Technologies (Wolters Kluwer Health), Vol. 44, No. suppl_1 ( 2013-02)
    Abstract: Purpose: In acute stroke patients when initiating Nasal-gastric tube feeding (NGF) have a high risk for aspiration pneumonia, which may be related to the body position. We investigated the relationship between body position during NGF and aspiration pneumonia. Method: We enrolled consecutive acute stroke patients, 1) who were admitted from June 2011 to May 2012, 2) with a diagnosis of acute stroke within five days, and 3) who initiated NGF within two days from admission due to altered mental state or severe dysphagia. We allocated these enrolled patients into two Group alternately according to the body position during NGF; patients in the complete lateral position (Group L [n=27]) with keeping nonparalyzed side below and head up at 30-60 degrees during NGF, and patients in the spine position (Group S [n=26] ) with head up at 30-60 degrees. We evaluated patients’ baseline characteristics including neurological status and vital signs, inflammatory response parameters, and the number of patients with aspiration pneumonia. Aspiration pneumonia fit three criteria: 1) at least one event of aspiration during NGF, 2) infiltrative shadows on the plain chest radiograph, and 3) no evidence of community acquired pneumonia. Results: We finally evaluated 47 patients (median age was 85 years old, 43% female). There were 32 patients with cerebral infarction and 15 with intracranial hemorrhage, median NIHSS score on admission was 17.5, and on the seventh day was 18 respectively. We analyzed 24 patients in Group L, and 23 in Group S. There was no difference in patients’ baseline characteristics, and inflammatory reaction parameters between the groups statistically significantly. However, the number of patients with aspiration pneumonia after admission was lower in Group L compared to Group S statistically significantly ( nine cases in Group L, 9 cases in Group S, P=0.034). Conclusion: The complete lateral position during the NGF has the potential to prevent aspiration pneumonia for acute stroke patients
    Type of Medium: Online Resource
    ISSN: 0039-2499 , 1524-4628
    RVK:
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2013
    detail.hit.zdb_id: 80381-9
    detail.hit.zdb_id: 1467823-8
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  • 3
    In: Arteriosclerosis, Thrombosis, and Vascular Biology, Ovid Technologies (Wolters Kluwer Health), Vol. 33, No. 5 ( 2013-05), p. 935-942
    Abstract: Macrophage (Mφ) migration rests on the adhesion/detachment between Mφ surface components and extracellular matrixes, and the contribution of numerous inflammatory disorders. Plasminogen activator inhibitor (PAI)-1, a serine protease inhibitor, influences Mφ motility through an action distinct from its classical modulation of the plasmin-based fibrinolytic process. We rely here on a small molecule PAI-1 inhibitor (TM5275) to investigate the role of PAI-1 in Mφ migration in the pathogenesis of renal injury. Approach and Results— Mφ migration was inhibited both in vitro and in vivo by TM5275. It was also reduced in T-cell–deficient nude mice, but not in PAI-1–deficient mice. Mφ migration hinged on the interaction of PAI-1 with low-density lipoprotein receptor–related protein, an interaction prevented by TM5275, but not with vitronectin, urokinase-type plasminogen activator, or tissue-type plasminogen activator. Fed to rats with anti–Thy-1–induced nephritis, TM5275 significantly decreased Mφ accumulation and ameliorated the progression of renal injury. Conclusions— These findings suggest that a small molecule PAI-1 inhibitor represents a novel class of anti-inflammatory agents targeting Mφ migration by the inhibition of the interaction of PAI-1 with low-density lipoprotein receptor–related protein.
    Type of Medium: Online Resource
    ISSN: 1079-5642 , 1524-4636
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2013
    detail.hit.zdb_id: 1221433-4
    detail.hit.zdb_id: 1494427-3
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