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  • Hindawi Limited  (2)
  • 2010-2014  (2)
  • 1
    In: BioMed Research International, Hindawi Limited, Vol. 2014 ( 2014), p. 1-10
    Abstract: The information about the crystal structure of porcine reproductive and respiratory syndrome virus (PRRSV) leader protease nsp1 α is available to analyze the roles of tRNA abundance of pigs and codon usage of the nsp1 α gene in the formation of this protease. The effects of tRNA abundance of the pigs and the synonymous codon usage and the context-dependent codon bias (CDCB) of the nsp1 α on shaping the specific folding units ( α -helix, β -strand, and the coil) in the nsp1 α were analyzed based on the structural information about this protease from protein data bank (PDB: 3IFU) and the nsp1 α of the 191 PRRSV strains. By mapping the overall tRNA abundance along the nsp1 α , we found that there is no link between the fluctuation of the overall tRNA abundance and the specific folding units in the nsp1 α , and the low translation speed of ribosome caused by the tRNA abundance exists in the nsp1 α . The strong correlation between some synonymous codon usage and the specific folding units in the nsp1 α was found, and the phenomenon of CDCB exists in the specific folding units of the nsp1 α . These findings provide an insight into the roles of the synonymous codon usage and CDCB in the formation of PRRSV nsp1 α structure.
    Type of Medium: Online Resource
    ISSN: 2314-6133 , 2314-6141
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2698540-8
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  • 2
    Online Resource
    Online Resource
    Hindawi Limited ; 2014
    In:  Mathematical Problems in Engineering Vol. 2014 ( 2014), p. 1-11
    In: Mathematical Problems in Engineering, Hindawi Limited, Vol. 2014 ( 2014), p. 1-11
    Abstract: A novel hybrid method, which simultaneously possesses the efficiency of Fourier spectral method (FSM) and the applicability of the finite element method (FEM), is presented for the vibration analysis of structures with elastic boundary conditions. The FSM, as one type of analytical approaches with excellent convergence and accuracy, is mainly limited to problems with relatively regular geometry. The purpose of the current study is to extend the FSM to problems with irregular geometry via the FEM and attempt to take full advantage of the FSM and the conventional FEM for structural vibration problems. The computational domain of general shape is divided into several subdomains firstly, some of which are represented by the FSM while the rest by the FEM. Then, fictitious springs are introduced for connecting these subdomains. Sufficient details are given to describe the development of such a hybrid method. Numerical examples of a one-dimensional Euler-Bernoulli beam and a two-dimensional rectangular plate show that the present method has good accuracy and efficiency. Further, one irregular-shaped plate which consists of one rectangular plate and one semi-circular plate also demonstrates the capability of the present method applied to irregular structures.
    Type of Medium: Online Resource
    ISSN: 1024-123X , 1563-5147
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2014442-8
    SSG: 11
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