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  • Hindawi Limited  (10)
  • 2010-2014  (10)
  • 1
    Online Resource
    Online Resource
    The S100B/RAGE Axis in Alzheimer's Disease
    Hindawi Limited ; 2010
    In:  Cardiovascular Psychiatry and Neurology Vol. 2010 ( 2010-06-21), p. 1-11
    Details
    In: Cardiovascular Psychiatry and Neurology, Hindawi Limited, Vol. 2010 ( 2010-06-21), p. 1-11
    Abstract: Increasing evidence suggests that the small EF-hand calcium-binding protein S100B plays an important role in Alzheimer's disease. Among other evidences are the increased levels of both S100B and its receptor, the Receptor for Advanced Glycation Endproducts (RAGEs) in the AD diseased brain. The regulation of RAGE signaling by S100B is complex and probably involves other ligands including the amyloid beta peptide (A), the Advanced Glycation Endproducts (AGEs), or transtheyretin. In this paper we discuss the current literature regarding the role of S100B/RAGE activation in Alzheimer's disease.
    Type of Medium: Online Resource
    ISSN: 2090-0163 , 2090-0171
    URL: Article
    DOI: 10.1155/2010/539581
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2010
    detail.hit.zdb_id: 2514153-3
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  • 2
    Online Resource
    Online Resource
    Finite Element Surface Registration Incorporating Curvature, Volume Preservation, and Statistical Model Information
    Hindawi Limited ; 2013
    In:  Computational and Mathematical Methods in Medicine Vol. 2013 ( 2013), p. 1-14
    Details
    In: Computational and Mathematical Methods in Medicine, Hindawi Limited, Vol. 2013 ( 2013), p. 1-14
    Abstract: We present a novel method for nonrigid registration of 3D surfaces and images. The method can be used to register surfaces by means of their distance images, or to register medical images directly. It is formulated as a minimization problem of a sum of several terms representing the desired properties of a registration result: smoothness, volume preservation, matching of the surface, its curvature, and possible other feature images, as well as consistency with previous registration results of similar objects, represented by a statistical deformation model. While most of these concepts are already known, we present a coherent continuous formulation of these constraints, including the statistical deformation model. This continuous formulation renders the registration method independent of its discretization. The finite element discretization we present is, while independent of the registration functional, the second main contribution of this paper. The local discontinuous Galerkin method has not previously been used in image registration, and it provides an efficient and general framework to discretize each of the terms of our functional. Computational efficiency and modest memory consumption are achieved thanks to parallelization and locally adaptive mesh refinement. This allows for the first time the use of otherwise prohibitively large 3D statistical deformation models.
    Type of Medium: Online Resource
    ISSN: 1748-670X , 1748-6718
    URL: Article
    DOI: 10.1155/2013/674273
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2013
    detail.hit.zdb_id: 2256917-0
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  • 3
    Online Resource
    Online Resource
    Patient Versus Parental Perceptions about Pain and Disability in Children and Adolescents with a Variety of Chronic Pain Conditions
    Hindawi Limited ; 2014
    In:  Pain Research and Management Vol. 19, No. 1 ( 2014), p. 7-14
    Details
    In: Pain Research and Management, Hindawi Limited, Vol. 19, No. 1 ( 2014), p. 7-14
    Abstract: BACKGROUND: Cross-informant variance is often observed in patient self-reports versus parent proxy reports of pediatric chronic pain and disability. OBJECTIVE: To assess the relationship and merit of the child versus parent perspective. METHODS: A total of 99 patients (eight to 17 years of age [mean 13.2 years]; 71% female, 81% Caucasian) and parents completed the Pediatric Pain Questionnaire and Functional Disability Inventory at their initial clinic visit. Patients’ and parents’ pain intensity and disability scores were analyzed using an intraclass correlation coefficient (ICC), Wilcoxon signed-rank test, Bland-Altman plot and Spearman’s correlation coefficient. The association between clinical/demographic variables and differences in patient/parent pain intensity and disability scores was assessed using multivariable regression. RESULTS: There was significant agreement between patients’ self-reports and parents’ proxy reports of their child’s pain intensity (ICC=0.52; P 〈 0.001) and disability (ICC=0.57; P=0.004) at the individual level. There were no significant group differences in patient versus parent-proxy pain intensity scores (P=0.40) and disability scores (P=0.54). The difference between patient and parent-proxy pain intensity was associated with patients’ self-reported pain intensity (P 〈 0.001). The difference between patient and parent-proxy disability was associated with patient’s self-reported pain disability (P 〈 0.001). Bland-Altman plots revealed major inter-rater variation in the Pediatric Pain Questionnaire and Functional Disability Inventory across their score ranges. A significant relationship (r=0.38; P 〈 0.001) was observed between patients’ self-reported pain intensity and disability. CONCLUSIONS: While equal merit should ideally be given to pediatric chronic pain patients’ self-reports and their parents’ proxy reports of pain intensity and disability, it would appear that, as needed, pediatric patients or parents can offer a clinically valid, single clinical perspective.
    Type of Medium: Online Resource
    ISSN: 1203-6765
    URL: Article
    DOI: 10.1155/2014/736053
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2048409-4
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  • 4
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    Online Resource
    Validation and Clinical Application of a Biopsychosocial Model of Pain Intensity and Functional Disability in Patients with a Pediatric Chronic Pain Condition Referred to a Subspecialty Clinic
    Hindawi Limited ; 2013
    In:  Pain Research and Treatment Vol. 2013 ( 2013-10-22), p. 1-12
    Details
    In: Pain Research and Treatment, Hindawi Limited, Vol. 2013 ( 2013-10-22), p. 1-12
    Abstract: Background . Pediatric chronic pain is considered to be a multidimensional construct that includes biological, psychological, and social components. Methods . The 99 enrolled study patients (mean age 13.2 years, 71% female, 81% Caucasian) and an accompanying parent completed a series of health-related questionnaires at the time of their initial appointment in a pediatric chronic pain medicine clinic. Results . Significant correlations (, ) were observed between pediatric chronic pain intensity and patient anxiety, patient depression, patient pain coping, parent chronic pain intensity, and parent functional disability. Pediatric chronic pain intensity was significantly associated with patient anxiety (). Significant correlations (, ) were observed between pediatric functional disability and patient chronic pain intensity, patient anxiety, patient depression, patient pain coping, parent chronic pain intensity, parent functional disability, parent anxiety, parent depression, and parent stress. Pediatric functional disability was significantly associated with patient chronic pain intensity (), patient anxiety (), patient pain coping (), and parent functional disability (). Conclusions . These findings provide empirical support of a multidimensional Biobehavioral Model of Pediatric Pain. However, the practical clinical application of the present findings and much of the similar previously published data may be tenuous.
    Type of Medium: Online Resource
    ISSN: 2090-1542 , 2090-1550
    URL: Article
    DOI: 10.1155/2013/143292
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2013
    detail.hit.zdb_id: 2603578-9
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  • 5
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    Online Resource
    A Model of Implant-Associated Infection in the Tibial Metaphysis of Rats
    Hindawi Limited ; 2013
    In:  The Scientific World Journal Vol. 2013 ( 2013), p. 1-8
    Details
    In: The Scientific World Journal, Hindawi Limited, Vol. 2013 ( 2013), p. 1-8
    Abstract: Objective . Implant-associated infections remain serious complications in orthopaedic and trauma surgery. A main scientific focus has thus been drawn to the development of anti-infective implant coatings. Animal models of implant-associated infections are considered helpful in the in vivo testing of new anti-infective implant coatings. The aim of the present study was to evaluate a novel animal model for generation of implant-associated infections in the tibial metaphysis of rats. Materials and Methods . A custom-made conical implant made of Ti6Al4V was inserted bilaterally at the medial proximal tibia of 26 female Sprague-Dawley rats. Staphylococcus aureus in amounts spanning four orders of magnitude and each suspended in 15  μ l phosphate buffered saline (PBS) was inoculated into the inner cavity of the implant after the implantation into the defined position. Controls were treated accordingly with PBS alone. Animals were then followed for six weeks until sacrifice. Implant-associated infection was evaluated by microbiological investigation using swabs and determination of viable bacteria in the bone around the implant and the biofilm on the implants after sonification. Results . Irrespective of the initial inoculum, all animals in the various groups harbored viable bacteria in the intraoperative swabs as well as the sonication fluid of the implant and the bone samples. No correlation could be established between initially inoculated CFU and population sizes on implant surfaces at sacrifice. However, a significantly higher viable count was observed from peri-implant bone samples for animals inoculated with 10 6  CFU. Macroscopic signs of animal infection (pus and abscess formation) were only observed for implants inoculated with at least 10 5  CFU S. aureus . Discussion/Conclusion . The results demonstrate the feasibility of this novel animal model to induce an implant-associated infection in the metaphysis of rats, even with comparatively low bacterial inocula. The specific design of the implant allows an application of bacteria in reproducible numbers at well-defined contact sites to the animal bone.
    Type of Medium: Online Resource
    ISSN: 1537-744X
    URL: Article
    DOI: 10.1155/2013/481975
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2013
    detail.hit.zdb_id: 2075968-X
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  • 6
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    Special Issue: Selected Papers from Super Computing 2012
    Hindawi Limited ; 2013
    In:  Scientific Programming Vol. 21, No. 3-4 ( 2013), p. 63-64
    Details
    In: Scientific Programming, Hindawi Limited, Vol. 21, No. 3-4 ( 2013), p. 63-64
    Type of Medium: Online Resource
    ISSN: 1058-9244 , 1875-919X
    URL: Article
    DOI: 10.1155/2013/370826
    RVK:
    SA 7860
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2013
    detail.hit.zdb_id: 2070004-0
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  • 7
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    Bilateral Pseudarthrosis of the Femoral Neck in a 25-Year-Old Male with Hereditary Hypophosphatemic Rickets
    Hindawi Limited ; 2014
    In:  Case Reports in Orthopedics Vol. 2014 ( 2014), p. 1-3
    Details
    In: Case Reports in Orthopedics, Hindawi Limited, Vol. 2014 ( 2014), p. 1-3
    Abstract: Hereditary hypophosphatemic rickets (HHR) is a rare disorder of renal phosphate wasting and the most common form of heritable rickets. Here, we report a case of an active 25-year-old male with HHR showing atraumatic bilateral femoral neck pseudarthrosis after 4 years of consecutive knee pain. A conservative therapy was administered, taking into account both the risks of surgical treatment and the little impairment even in the sport activities which the patient experienced.
    Type of Medium: Online Resource
    ISSN: 2090-6749 , 2090-6757
    URL: Article
    DOI: 10.1155/2014/312712
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2684648-2
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  • 8
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    The MAJORANA DEMONSTRATOR Neutrinoless Double-Beta Decay Experiment
    Hindawi Limited ; 2014
    In:  Advances in High Energy Physics Vol. 2014 ( 2014), p. 1-18
    Details
    In: Advances in High Energy Physics, Hindawi Limited, Vol. 2014 ( 2014), p. 1-18
    Abstract: The M ajorana D emonstrator will search for the neutrinoless double-beta ( β β 0 ν ) decay of the isotope Ge with a mixed array of enriched and natural germanium detectors. The observation of this rare decay would indicate that the neutrino is its own antiparticle, demonstrate that lepton number is not conserved, and provide information on the absolute mass scale of the neutrino. The D emonstrator is being assembled at the 4850-foot level of the Sanford Underground Research Facility in Lead, South Dakota. The array will be situated in a low-background environment and surrounded by passive and active shielding. Here we describe the science goals of the D emonstrator and the details of its design.
    Type of Medium: Online Resource
    ISSN: 1687-7357 , 1687-7365
    URL: Article
    DOI: 10.1155/2014/365432
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2014
    detail.hit.zdb_id: 2389407-6
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  • 9
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    Bilateral Breast Masses with a Rare Etiology
    Hindawi Limited ; 2013
    In:  Case Reports in Oncological Medicine Vol. 2013 ( 2013), p. 1-4
    Details
    In: Case Reports in Oncological Medicine, Hindawi Limited, Vol. 2013 ( 2013), p. 1-4
    Abstract: Breast masses have a variety of benign and malignant etiologies. We present the case of a 28-year-old woman with bilateral large painful breast masses that developed rapidly in the three weeks before first presentation. Further investigation revealed bilateral ovarian masses. Biopsies of both ovarian masses were taken, and the pathology reported Burkitt’s lymphoma. Additional staging with a PET scan was suggestive of bone marrow involvement, but bone marrow biopsy was negative. Examination of the cerebrospinal fluid did not identify malignant cells. The patient underwent CODOX-M/IVAC chemotherapy, and a complete response was demonstrated after one cycle of treatment. Six months after finishing chemotherapy the patient remained in complete remission. To our knowledge this is the first case reporting simultaneous involvement of breast, ovaries, and bones in Burkitt’s lymphoma. Gynecologists and oncologists should be aware of this pattern. Polychemotherapy treatment must be initiated rapidly with curative intent.
    Type of Medium: Online Resource
    ISSN: 2090-6706 , 2090-6714
    URL: Article
    DOI: 10.1155/2013/412368
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2013
    detail.hit.zdb_id: 2629911-2
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  • 10
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    OCV Hysteresis in Li-Ion Batteries including Two-Phase Transition Materials
    Hindawi Limited ; 2011
    In:  International Journal of Electrochemistry Vol. 2011 ( 2011), p. 1-6
    Details
    In: International Journal of Electrochemistry, Hindawi Limited, Vol. 2011 ( 2011), p. 1-6
    Abstract: The relation between batteries' state of charge (SOC) and open-circuit voltage (OCV) is a specific feature of electrochemical energy storage devices. Especially NiMH batteries are well known to exhibit OCV hysteresis, and also several kinds of lithium-ion batteries show OCV hysteresis, which can be critical for reliable state estimation issues. Electrode potential hysteresis is known to result from thermodynamical entropic effects, mechanical stress, and microscopic distortions within the active electrode materials which perform a two-phase transition during lithium insertion/extraction. Hence, some Li-ion cells including two-phase transition active materials show pronounced hysteresis referring to their open-circuit voltage. This work points out how macroscopic effects, that is, diffusion limitations, superimpose the latte- mentioned microscopic mechanisms and lead to a shrinkage of OCV hysteresis, if cells are loaded with high current rates. To validate the mentioned interaction, Li-ion cells' state of charge is adjusted to 50% with various current rates, beginning from the fully charged and the discharged state, respectively. As a pronounced difference remains between the OCV after charge and discharge adjustment, obviously the hysteresis vanishes as the target SOC is adjusted with very high current rate.
    Type of Medium: Online Resource
    ISSN: 2090-3537
    URL: Article
    DOI: 10.4061/2011/984320
    Language: English
    Publisher: Hindawi Limited
    Publication Date: 2011
    detail.hit.zdb_id: 2614327-6
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