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  • Hindawi  (2)
  • MDPI Publishing  (1)
  • 2010-2014  (3)
  • 1
    Publication Date: 2014-08-20
    Description: Gestational diabetes mellitus (GDM) is one of the most common pregnancy complications. Inflammation may play a role in the pathogenesis of GDM. We performed a systematic review and meta-analysis to determine whether maternal serum concentration of tumor necrosis factor-alpha (TNF-α), leptin, and adiponectin were associated with GDM. A systematic search of PubMed and Medline was undertaken. In total, 27 trials were evaluated by meta-analyses using the software Review Manager 5.0. The results showed that maternal TNF-α () and leptin () concentrations were significantly higher in GDM patients versus controls. However, maternal adiponectin () concentration was significantly lower in GDM patients compared with controls. Subgroup analysis taking in consideration the effect of obesity on maternal adipokine levels showed that circulating levels of TNF-α and leptin remained elevated in GDM patients compared to their body mass index (BMI) matched controls, and adiponectin level remained depressed in GDM individuals. Our findings strengthen the clinical evidence that GDM is accompanied by exaggerated inflammatory responses.
    Electronic ISSN: 1537-744X
    Topics: Natural Sciences in General
    Published by Hindawi
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  • 2
    Publication Date: 2014-12-08
    Description: Objectives. The utility of informant AD8 for case finding of cognitive impairment at primary healthcare settings is unknown and therefore its feasibility and acceptability for targeted screening at a primary healthcare clinic should be investigated. Methods. The informants of older adult patients attending a primary healthcare clinic in Singapore were administered the AD8. Positive screening findings were provided to patients’ primary care physicians for referrals to specialist memory clinics. The acceptability of AD8 was evaluated by collecting feedbacks from the informants and primary care physicians. Results. 205 patients and their informants were recruited. However, 6 (2.9%) informants were uncontactable, while the majority of the remaining 199 patients with completed AD8 (96.5%, ) found it acceptable where 59 (29.6%) patients were deemed cognitively impaired (AD8 ≥ 2). Clinicians (100%, ) found the AD8 helpful in facilitating referrals to memory clinics. However, most referral recommendations (81.4%, ) were declined by patients and/or informant due to limited insight of implications of cognitive impairment. Conclusions. The AD8 can be easily administered and is well tolerated. It detected cognitive impairment in one-third of older adult patients and therefore may be useful for case finding of cognitive impairment in the primary healthcare.
    Electronic ISSN: 1537-744X
    Topics: Natural Sciences in General
    Published by Hindawi
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  • 3
    Publication Date: 2014-07-17
    Description: One key reason for the failure of Jatropha plantation is the use of non-improved planting materials. We present in this paper a Jatropha variety (JO S2) through selective breeding with much better seed productivity than wild accessions as proven by field trials in Singapore and India. In a single farm trial in Singapore for two years, a comparison was conducted with accessions from China, India, Indonesia and Africa. It was found that all traits studied like seed yield, seed kernel content, seed oil content, fatty acid composition, phosphorus content and PE content differed significantly among and within the wild accessions. Overall, JO S2 was the best performer with the highest seed yield, high oil content and low phosphorus content. On two sites in Tamil Nadu, Southern India, this Jatropha variety produced up to 2.95 ton/ha of dry seeds in the first year and up to 4.25 ton/ha of dry seeds in the second year, much better than the local variety control. We attribute its higher seed productivity to early flowering, better self-branching, more flower/fruiting bunches, more fruits per bunch and importantly, better uniformity among plants. This exemplifies that breeding has improved Jatropha seed productivity which will lead to better economics for Jatropha plantation.
    Electronic ISSN: 2071-1050
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by MDPI Publishing
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