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  • 1
    In: Acta Cirurgica Brasileira, FapUNIFESP (SciELO), Vol. 27, No. 9 ( 2012-09), p. 634-638
    Abstract: OBJETIVO: Avaliar a atividade antitumoral do extrato alcoólico do chá verde (C. sinensis). MÉTODOS: Quatro grupos de seis ratos Wistar foram inoculados com 1x10(6) células/mL do tumor de Walker por via intramuscular. Os grupos foram tratados durante 10 dias, por gavagem, com salina 0,9 % (Grupo I, controle negativo), 20 mg/Kg de tamoxifeno (Grupo II, controle positivo) e extrato alcoólico de C. sinensis nas doses de 0,07 g/Kg (Grupo III) ou 0,14 g/Kg (Grupo IV). O volume e a inibição do crescimento tumoral foram calculados. RESULTADOS: A média dos pesos dos animais foi maior no Grupo IV do que no Grupo II (p=0,0107). O peso tumoral do Grupo IV foi menor do que o Grupo I (p=0,0062), mas não houve diferença quando comparado ao Grupo II. O volume tumoral foi menor nos grupos II e IV quando comparados ao Grupo I (p=0,0131). Inibição tumoral foi observada nos Grupos II = 44,67 ± 32,47, III = 16,83 ± 53,02 e IV = 66,4 ± 25,82 (p 〉 0,05). Não houve diferença no peso dos órgãos entre os grupos. CONCLUSÃO: O extrato alcoólico do chá verde possui ação antitumoral.
    Type of Medium: Online Resource
    ISSN: 0102-8650
    Language: Unknown
    Publisher: FapUNIFESP (SciELO)
    Publication Date: 2012
    detail.hit.zdb_id: 2012156-8
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  • 2
    In: Revista Brasileira de Zootecnia, FapUNIFESP (SciELO), Vol. 41, No. 5 ( 2012-05), p. 1236-1242
    Abstract: The objective of this study was to analyze the stress effect, via administration of ACTH (adrenocorticotropic hormone), on quantity and quality of milk produced and also the indication of stress by alteration of cortisol level. Twelve milking goats were divided in two groups: six animals were subjected to intravenous application of 0.06 UI of ACTH/kg of LW (challenged) and six received placebo solution (control). The challenge occurred during milking with protocol application at 30, 60, 120 and 180 days from the beginning of milking; each date the levels of cortisol were evaluated 30 minutes before, at the application of ACTH, 60, 120 and 300 minutes after ACTH. The milk production was measured daily during 270 days and every twenty days the milk was collected for somatic cell count (SCC) by the direct method. The cortisol levels measured at -30 and zero minutes before ACTH applications were low and similar between the goat groups. However, after 60 minutes it was verified the effect of ACTH application, and cortisol contents of 61.37±6.65 versus 5.47±1.21 ng/mL and of 51.17±10.21 versus 4.67±1.21 ng/mL at 120 minutes. At 300 minutes, the cortisol returned to basal level. There was no significant difference of milk production, protein contents and milk fat; groups ACTH and placebo produced 1.37±0.59 and 1.38±0.63 kg of milk, respectively. The somatic cell count was not influenced by ACTH stress and presented values located within the range indicated for healthy animals. Punctual stress originated from ACTH application was verified, but without alterations of quantitative and qualitative nature of milk produced, indicating that management activities that punctually stress animals do not bring production impairment.
    Type of Medium: Online Resource
    ISSN: 1516-3598
    Language: Unknown
    Publisher: FapUNIFESP (SciELO)
    Publication Date: 2012
    detail.hit.zdb_id: 2078814-9
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