In:
Beilstein Journal of Organic Chemistry, Beilstein Institut, Vol. 10 ( 2014-08-07), p. 1808-1816
Abstract:
Macroscopic gelatinous colonies of freshwater cyanobacterium Aphanothece sacrum , a luxury ingredient for Japanese cuisine, were found to contain a new oxylipin-derived macrolide, sacrolide A ( 1 ), as an antimicrobial component. The configuration of two chiral centers in 1 was determined by a combination of chiral anisotropy analysis and conformational analysis of different ring-opened derivatives. Compound 1 inhibited the growth of some species of Gram-positive bacteria, yeast Saccharomyces cerevisiae and fungus Penicillium chrysogenum , and was also cytotoxic to 3Y1 rat fibroblasts. Concern about potential food intoxication caused by accidental massive ingestion of A. sacrum was dispelled by the absence of 1 in commercial products. A manual procedure for degrading 1 in raw colonies was also developed, enabling a convenient on-site detoxification at restaurants or for personal consumption.
Type of Medium:
Online Resource
ISSN:
1860-5397
Language:
English
Publisher:
Beilstein Institut
Publication Date:
2014
detail.hit.zdb_id:
2192461-2
Permalink
