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  • American Association for Cancer Research (AACR)  (3)
  • 2010-2014  (3)
  • 1
    Online Resource
    Online Resource
    Abstract B23: Evaluating an intervention to improve perceptions of cancer clinical trials among minority communities in South Carolina
    American Association for Cancer Research (AACR) ; 2010
    In:  Cancer Prevention Research Vol. 3, No. 1_Supplement ( 2010-01-07), p. B23-B23
    Details
    In: Cancer Prevention Research, American Association for Cancer Research (AACR), Vol. 3, No. 1_Supplement ( 2010-01-07), p. B23-B23
    Abstract: Objective: Cancer mortality rates for African Americans in South Carolina are among the highest in the nation. However, African Americans are less likely than other groups to participate in cancer clinical trials. Results of previous investigations have shown that their low participation rates are related to negative perceptions of trials. We conducted a community based cancer clinical trials education intervention to improve perceptions of cancer clinical trials in this population. Methods: The study was conducted at eight different sites in six counties in South Carolina. The intervention consisted of a 30-minute cancer clinical trials educational presentation developed by the National Institutes of Health/National Cancer Institute. The intervention was part of a larger 3.5-hour education program aimed at increasing general cancer knowledge, prostate cancer knowledge, and perceived self efficacy in patient-physician interaction among minority populations in South Carolina. Study participants were recruited by community partners in each locale where the training sessions were conducted. A pre- and post-intervention survey was administered immediately before and after the intervention was delivered at each site. The survey instrument included seven items. Sample items include the following: Do you think that patients should be asked to take part in medical research? Would you be prepared to take part in a study comparing different treatments? Would you be prepared to take part in a study where treatment was chosen at random? Results: The study sample consisted of 164 predominantly African American participants. One-hundred and twenty-five (78.6%) of the 159 participants who provided data on race were African American, 19 (12.0%) were Caucasian and 15 (9.4%) were Native American. The majority of the 160 participants who provided data on age were ages 50+ years (62.5%). The majority of the 154 participants who reported their income had an annual household income & gt; = $40,000 (53.8%). For each of the seven survey items assessing perceptions of cancer clinical trials, 74%, 69%, 56%, 49%, 61%, 50% and 58% of the participants, respectively, changed to more favorable responses on the post-test vs. pre-test. All results were statistically significant at the p & lt;0.001 level. Conclusions: Providing cancer clinical trials information to African American community members positively influenced their trial perceptions. Future research could incorporate a longer follow-up assessment period. Citation Information: Cancer Prev Res 2010;3(1 Suppl):B23.
    Type of Medium: Online Resource
    ISSN: 1940-6207 , 1940-6215
    URL: Article
    DOI: 10.1158/1940-6207.PREV-09-B23
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2010
    detail.hit.zdb_id: 2422346-3
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  • 2
    Online Resource
    Online Resource
    Abstract 4606: An in vitro and in vivo evaluation of novel anticancer agents in a triple negative breast cancer model
    American Association for Cancer Research (AACR) ; 2010
    In:  Cancer Research Vol. 70, No. 8_Supplement ( 2010-04-15), p. 4606-4606
    Details
    In: Cancer Research, American Association for Cancer Research (AACR), Vol. 70, No. 8_Supplement ( 2010-04-15), p. 4606-4606
    Abstract: Patients diagnosed with triple negative breast cancer, which is the absence of the estrogen (ER), progesterone (PR), and Her2/neu receptor have a poor prognosis and there is a critical need to develop novel antineoplastic agents for this breast cancer sub-type. Therefore, the focus of this project is to identify novel anticancer agents with in vitro and in vivo antiproliferative activity in a triple negative breast cancer model. Previously, our laboratory synthesized a group of novel isochalcones called DJ compounds that demonstrated significant in vitro antiproliferative effects. Cell proliferation of MDA-MB-231 cells was measured using the alamar blue dye method and produced IC50 values of DJ52, DJ56, and DJ82 at 10−6M, 10−5M, and 10−5M, respectively. Binding studies have indicated that these agents do not bind the ER but appear to inhibit a phosphorylation step in the epidermal growth factor (EGFR) receptor pathway. In vivo studies were also conducted by implanting tumors derived from MDA-MB231 cells into SCID mice to determine tumor regression was measured over 20 days. DJ52 at 50mg/kg caused significant decrease (p value & lt;.05) decreased tumor volume by nearly fifty percent compared to the control with vehicle alone. Therefore, these data suggests that DJ52 has merit for further evaluation for potential intervention in patients diagnosed with triple negative breast cancer. Our laboratory continues our efforts to understand the mechanism of action of these agents to potentially provide alternative pharmacological options for these patients for better health outcomes. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 101st Annual Meeting of the American Association for Cancer Research; 2010 Apr 17-21; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2010;70(8 Suppl):Abstract nr 4606.
    Type of Medium: Online Resource
    ISSN: 0008-5472 , 1538-7445
    URL: Article
    DOI: 10.1158/1538-7445.AM10-4606
    RVK:
    XA 36000
    RVK:
    XA 10000
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2010
    detail.hit.zdb_id: 2036785-5
    detail.hit.zdb_id: 1432-1
    detail.hit.zdb_id: 410466-3
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  • 3
    Online Resource
    Online Resource
    Efficacy of Exercise Interventions in Modulating Cancer-Related Fatigue among Adult Cancer Survivors: A Meta-Analysis
    American Association for Cancer Research (AACR) ; 2011
    In:  Cancer Epidemiology, Biomarkers & Prevention Vol. 20, No. 1 ( 2011-01-01), p. 123-133
    Details
    In: Cancer Epidemiology, Biomarkers & Prevention, American Association for Cancer Research (AACR), Vol. 20, No. 1 ( 2011-01-01), p. 123-133
    Abstract: Background: The purpose of this meta-analysis was to explore the efficacy of exercise as a nonpharmacologic intervention to reduce cancer-related fatigue (CRF) among adult cancer survivors. We also investigated how different components of the exercise prescription (Ex Rx), methodologic considerations, and subject characteristics modulate CRF. Methods: A systematic search for randomized controlled trials was conducted using words related to cancer, exercise, and fatigue. Results: In total, 44 studies with 48 interventions qualified, including 3,254 participants of varying cancer types, stages of diagnosis, treatments, and exercise interventions. Cancer survivors in exercise interventions reduced their CRF levels to a greater extent than usual care controls, d+ = 0.31 (95% CI = 0.22–0.40), an effect that appeared to generalize across several types of cancer. CRF levels improved in direct proportion to the intensity of resistance exercise (β = 0.60, P = 0.01), a pattern that was stronger in higher quality studies (β = 0.23, P & lt; 0.05). CRF levels also reduced to a greater extent when interventions were theoretically driven (β = 0.48, P & lt; 0.001) or cancer survivors were older (β = 0.24, P = 0.04). Conclusions: Exercise reduced CRF especially in programs that involved moderate-intensity, resistance exercise among older cancer survivors and that were guided by theory. Impact: Our results indicate exercise interventions for adult cancer survivors should be multi-dimensional and individualized according to health outcome and cancer type. Cancer Epidemiol Biomarkers Prev; 20(1); 123–33. ©2011 AACR.
    Type of Medium: Online Resource
    ISSN: 1055-9965 , 1538-7755
    URL: Article
    DOI: 10.1158/1055-9965.EPI-10-0988
    Language: English
    Publisher: American Association for Cancer Research (AACR)
    Publication Date: 2011
    detail.hit.zdb_id: 2036781-8
    detail.hit.zdb_id: 1153420-5
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