Publication Date:
2014-02-01
Description:
Article Peptide drugs are attractive as therapeutics for gut-based applications, although they may be susceptible to reduction and degradation. Here, the authors develop seleno-oxytocin analogues, with enhanced stability at no cost to potency, and demonstrate their efficacy at colonic nociceptor inhibition in a mouse model. Nature Communications doi: 10.1038/ncomms4165 Authors: Aline Dantas de Araujo, Mehdi Mobli, Joel Castro, Andrea M. Harrington, Irina Vetter, Zoltan Dekan, Markus Muttenthaler, JingJing Wan, Richard J. Lewis, Glenn F. King, Stuart M. Brierley, Paul F. Alewood
Electronic ISSN:
2041-1723
Topics:
Biology
,
Chemistry and Pharmacology
,
Natural Sciences in General
,
Physics
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