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  • 2010-2014  (82)
  • 1970-1974  (4)
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  • 1
    Publication Date: 2022-05-26
    Description: Author Posting. © American Meteorological Society, 2009. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Bulletin of the American Meteorological Society 90 (2009):459-480, doi:10.1175/2008BAMS2608.1.
    Description: The Indian Ocean is unique among the three tropical ocean basins in that it is blocked at 25°N by the Asian landmass. Seasonal heating and cooling of the land sets the stage for dramatic monsoon wind reversals, strong ocean–atmosphere interactions, and intense seasonal rains over the Indian subcontinent, Southeast Asia, East Africa, and Australia. Recurrence of these monsoon rains is critical to agricultural production that supports a third of the world's population. The Indian Ocean also remotely influences the evolution of El Niño–Southern Oscillation (ENSO), the North Atlantic Oscillation (NAO), North American weather, and hurricane activity. Despite its importance in the regional and global climate system though, the Indian Ocean is the most poorly observed and least well understood of the three tropical oceans. This article describes the Research Moored Array for African–Asian–Australian Monsoon Analysis and Prediction (RAMA), a new observational network designed to address outstanding scientific questions related to Indian Ocean variability and the monsoons. RAMA is a multinationally supported element of the Indian Ocean Observing System (IndOOS), a combination of complementary satellite and in situ measurement platforms for climate research and forecasting. The article discusses the scientific rationale, design criteria, and implementation of the array. Initial RAMA data are presented to illustrate how they contribute to improved documentation and understanding of phenomena in the region. Applications of the data for societal benefit are also described.
    Repository Name: Woods Hole Open Access Server
    Type: Article
    Format: application/pdf
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  • 2
    Publication Date: 2022-05-26
    Description: Author Posting. © American Meteorological Society, 2009. This article is posted here by permission of American Meteorological Society for personal use, not for redistribution. The definitive version was published in Bulletin of the American Meteorological Society 90 (2009): ES5-ES8, doi:10.1175/2008BAMS2608.2.
    Repository Name: Woods Hole Open Access Server
    Type: Article
    Format: application/pdf
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Journal of the American Water Resources Association 8 (1972), S. 0 
    ISSN: 1752-1688
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Architecture, Civil Engineering, Surveying , Geography
    Notes: . A regional authority is postulated as the pollution abatement agency. The authority's task is to minimize the total cost of waste treatment to the region. Data from the Miami River in Ohio are used to model a twenty-seven reach river with fifteen BOD dischargers. The description of the system model is given in terms of linear inequality constraints and a quadratic objective function. The multilevel approach with a two level optimization hierarchy in then applied. The river system model is decomposed into twenty-seven subsystems (reaches). At the first level (local level), each subsystem is “independently” optimized. At the second level (regional level) the subsystems' solutions are coordinated to yield an overall optimum to the whole region. Two types of second level coordination schemes are presented for the decentralized decision making process. The first assumes a knowledge of the local treatment cost functions by the regional authority; the other assumes no such knowledge. A discussion of the multilevel optimization approach and the coordination algorithms for both schemes is presented. In addition, the physical interpretation of effluent charges imposed by the regional authority on each user (polluter) is given. This paper presents computational results to complement the theoretical discussions on the multilevel approach [Haimes, 1971a].
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Optical and quantum electronics 6 (1974), S. 243-244 
    ISSN: 1572-817X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Electrical Engineering, Measurement and Control Technology , Physics
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Cellular and molecular life sciences 27 (1971), S. 831-832 
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Résumé L'introduction d'un groupe phényl facilite grandement le transfert del-alanine tandis que l'hydroxylation du groupe phényl diminue la facilité de transfert.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 25 (1973), S. 149-160 
    ISSN: 1432-0533
    Keywords: Nutritional Encephalopathy ; Brain Edema ; Vitamin E Deficiency ; Electron Microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Focal lesions were induced in the cerebellum by feeding chickens a diet high in unsaturated fats and deficient in vitamin E. Ultrastructurally, the lesions consisted of central and peripheral zones. The central zone was characterized in the cortex and white matter by enlargement of the intercellular space, swelling of astrocytes, vacuolization of oligodendrocytes, ballooning of nerve fibers, degenerative changes in small blood vessels, and extravasation of plasma and blood cells. The peripheral zone was characterized by enlargement of the intercellular space in the white matter, swelling of astrocytes in the cortex, and the accumulation of dark bodies in the endothelium of small blood vessels. The results suggest that this nutritional encephalopathy is caused by alterations in the permeability of the vascular bed due to the dietary stress of unsaturated fatty acids in the absence of vitamin E.
    Type of Medium: Electronic Resource
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  • 7
    Publication Date: 2012-04-25
    Description: The epithelial cell tight junction separates apical and basolateral domains and is essential for barrier function. Disruption of the tight junction is a hallmark of epithelial cell damage and can lead to end organ damage including renal failure. Herein, we identify Gα12 activation by H2O2 leading to tight junction disruption and demonstrate a critical role for Gα12 activation during bilateral renal ischemia/reperfusion injury. Madin–Darby canine kidney (MDCK) cells with inducible Gα12 (Gα12-MDCK) and silenced Gα12 (shGα12-MDCK) were subjected to ATP depletion/repletion and H2O2/catalase as models of tight junction disruption and recovery by monitoring transepithelial resistance. In ATP depleted cells, barrier disruption and recovery was not affected by Gα12, but reassembly was accelerated by Gα12 depletion. In contrast, silencing of Gα12 completely protected cells from H2O2-stimulated barrier disruption, a response that rapidly occurred in control cells. H2O2 activated Src and Rho, and Src inhibition (by PP2), but not Rho (by Y27632), protected cells from H2O2-mediated barrier disruption. Immunofluorescent and biochemical analysis showed that H2O2 led to increased tyrosine phosphorylation of numerous proteins and altered membrane localization of tight junction proteins through Gα12/Src signaling pathway. Gα12 and Src were activated in vivo during ischemia/reperfusion injury, and transgenic mice with renal tubular QLα12 (activated mutant) expression were delayed in recovery and showed more extensive injury. Conversely, Gα12 knockout mice were nearly completely protected from ischemia/reperfusion injury. Taken together, these studies reveal that ROS stimulates Gα12 to activate injury pathways and identifies a therapeutic target for ameliorating ROS mediated injury.
    Print ISSN: 0027-8424
    Electronic ISSN: 1091-6490
    Topics: Biology , Medicine , Natural Sciences in General
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  • 8
    Publication Date: 2013-06-11
    Description: Two hot spot mutant p53 mouse models display differential gain of function in tumorigenesis Cell Death and Differentiation 20, 898 (July 2013). doi:10.1038/cdd.2013.17 Authors: W Hanel, N Marchenko, S Xu, S Xiaofeng Yu, W Weng & U Moll
    Keywords: HUPKIgain of functionLSKMSC
    Print ISSN: 1350-9047
    Electronic ISSN: 1476-5403
    Topics: Biology , Medicine
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  • 9
    Publication Date: 2013-07-25
    Description: Synergistic antitumour activity of sorafenib in combination with tetrandrine is mediated by reactive oxygen species (ROS)/Akt signaling British Journal of Cancer 109, 342 (23 July 2013). doi:10.1038/bjc.2013.334 Authors: J Wan, T Liu, L Mei, J Li, K Gong, C Yu & W Li
    Keywords: sorafenibtetrandrinesynergistic antitumourapoptosis
    Print ISSN: 0007-0920
    Electronic ISSN: 1532-1827
    Topics: Medicine
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  • 10
    Publication Date: 2013-07-05
    Description: An ionic liquid (IL), 1-butylimidazole hexafluoride phosphate [bmim]PF 4 , was dispersed in surfactant solution to form an IL-in-water emulsion. Physical absorption of CO 2 was carried out in this emulsion system. Absorption rates of CO 2 under different operating conditions were obtained by experimental measurements. CO 2 concentrations in the bulk of absorbent and the local volumetric mass transfer coefficients of the liquid phase were calculated by model calculation. Experimental results indicate that the dispersed IL droplets in aqueous solution can significantly enhance CO 2 mass transfer at the gas-liquid interface. This phenomenon can be ascribed to the increase of mass transfer driving force and local volumetric mass transfer coefficient. The shuttle effect and hydrodynamic effect proved to play important roles for CO 2 absorption improved by dispersed IL. The ionic liquid 1-butylimidazole hexafluoride phosphate [bmim]PF 4 is dispersed into water to create an ionic liquid-in-water emulsion which is applied to absorb CO 2 . The presence of dispersed ionic liquid droplets significantly enhances the CO 2 mass transfer rate at a gas-liquid interface due to both the shuttle effect and hydrodynamic effect.
    Print ISSN: 0930-7516
    Electronic ISSN: 1521-4125
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Published by Wiley-Blackwell
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