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  • 2010-2014  (6)
  • 1975-1979  (3)
  • 1945-1949  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Influence of intratubular pressure on proximal tubular compliance and capillary diameter in the rat kidney (1979)
    Springer
    Pflügers Archiv 382 (1979), S. 179-187 
    Details
    ISSN: 1432-2013
    Keywords: Tubular compliance ; Capillary diameter ; Tubular diameter ; Rat kidney
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Tubular compliance is the response of tubular diameter to changes in intratubular pressure [7]. Proximal tubular compliance was determined directly by measurements of tubular diameter and pressure and indirectly using a mathematical model of tubular fluid flow based on measurements of the hydraulic pressure gradients along the tubule under free flow conditions and during an induced pressure reduction at the end of the proximal tubule. The two independent methods yielded similar values for compliance. Proximal tubular complicance was found to depend upon the intratubular pressure: tubular compliance was significantly higher (P〈0.001) when the intratubular pressure was reduced below normal (1.0 μm cm H2O−1) than when the pressure was increased above the control value (0.4 μm cm H2O−1) Almost identical compliance values were measured in sodium pentobarbital and inactin anaesthetized rats (P〉0.8). Intratubular pressure changes resulted in inverse changes in the diameters of the adjacent capillaries, suggesting that the peritubular capillaries are distensible structures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00584220
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Angiotensin II induced reduction of peritubular capillary diameter in the rat kidney (1977)
    Springer
    Pflügers Archiv 371 (1977), S. 245-250 
    Details
    ISSN: 1432-2013
    Keywords: Angiotensin II ; Capillary contractility ; Rat kidney
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Large peritubular capillaries were infused consecutively (20 nl · min−1) in random sequence with isotonic saline and angiotensin II (20–80 ng · ml−1). The diameters of the infused capillaries were measured, without knowledge of the infusate used, from colour photographs of the infused area. Angiotensin II induced a significant (p〈0.001) decrease in capillary diameter (Δ=−1.2±0.2 (SE) μm and Δ=−2.1±0.2 (SE) μm with 20 ng · ml−1 and 80 ng · ml−1 angiotensin II infusates, respectively). This decrease was shown to be independent of external tubular compression: separate experiments in which the surrounding tubules were collapsed by injection of oil blocks yielded similar results. The possibility that the observed reduction in diameter was caused by an angiotensin II induced change in capillary permeability to the staining solution was excluded, since the angiotensin II effect was unchanged when fluorescent dextran (mol. wt. 150000) was substituted for lissamin green. These experiments indicate that peritubular capillaries contract actively when infused with angiotensin II.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00586264
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Zur Abspaltung von Protonen aus Atomkernen durch Gammastrahlen (1948)
    Springer
    Naturwissenschaften 35 (1948), S. 190-190 
    Details
    ISSN: 1432-1904
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00627388
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The interstitial cells in the renal medulla of rat, rabbit, and gerbil in different states of diuresis (1978)
    Springer
    Cell & tissue research 189 (1978), S. 1-18 
    Details
    ISSN: 1432-0878
    Keywords: Kidney medulla ; Rat, rabbit, gerbil ; Interstitial cells ; Lipid droplets ; Electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The inner zone of the renal medulla of rats, gerbils, and rabbits was investigated to determine whether or not there are any characteristic ultrastructural differences between the interstitial cells of these species. The effects on the interstitial cells of water deprivation and water loading were also investigated. In all three species, the Type 1 interstitial cells, the lipid containing cells, were abundant and their distribution and topographical relations as well as their general ultrastructure were similar. The previously reported significantly higher frequency in desert rats could not be confirmed. Although the lipid droplets of the interstitial cells were smaller in gerbils and rabbits when compared to rats, their fine structure was similar. Their electron dense outer zone was sometimes associated with a granular material and/or a lamellar material with a periodicity of about 40 Å resembling phospholipid “myelin figures”. Water-loaded rats showed a considerable increase in the number of lipid droplets when compared to dehydrated or untreated animals. In contrast, the interstitial cells of waterloaded gerbils and rabbits were depleted of lipid droplets.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00223117
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    Paper (German National Licenses)
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  • 5
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    Soot Reactivity in Conventional Combustion and Oxy-fuel Combustion Environments (2013)
    American Chemical Society (ACS)
    Details
    Publication Date: 2013-04-17
    Description: Energy & Fuels DOI: 10.1021/ef400620g
    Print ISSN: 0887-0624
    Electronic ISSN: 1520-5029
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering , Process Engineering, Biotechnology, Nutrition Technology
    Published by American Chemical Society (ACS)
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  • 6
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    Global variations of HDO and HDO/H2O ratios in the upper troposphere and lower stratosphere derived from ACE-FTS satellite measurements (2012)
    Wiley-Blackwell
    Details
    Publication Date: 2012-03-22
    Description: High-quality satellite observations of water and deuterated water in the upper troposphere and lower stratosphere (UTLS) from the Atmospheric Chemistry Experiment Fourier transform spectrometer (ACE-FTS) are used to map global climatological behavior. Spatial and temporal variability in these data suggest that convection plays a significant role in setting water vapor isotopic composition in these regions. In many instances, enhancements in HDO/H2O (i.e., δD) are closely tied to patterns of climatological deep convection and uncorrelated with water vapor, although convection appears to have different isotopic effects in different locations. The ACE-FTS data reveal seasonal variations in the tropics and allow mapping of climatological regional structure. These data reveal strong regional isotopic enhancement associated with the North American summer monsoon but not the Asian monsoon or the western Pacific warm pool. We suggest that the isotopic effects of deep convection near the tropopause are moderated by the ambient relative humidity, which controls the amount of convective ice that evaporates. Local convective signals can in turn affect global behavior: the North America monsoon influence introduces a Northern Hemisphere–Southern Hemisphere asymmetry in water isotopic composition in the lower stratosphere that extends into the tropics and influences the apparent seasonal cycle in averaged tropical UTLS data. Seasonal variation in tropical lower stratospheric water isotopic composition extends up to ∼20 km in ACE retrievals, but in contrast to previous reports, there is no clear evidence of propagation beyond the lowermost stratosphere. The reliability of these observations is supported by the broad consistency of ACE-FTS averaged tropical profiles with previous remote and in situ δD measurements.
    Print ISSN: 0148-0227
    Topics: Geosciences , Physics
    Published by Wiley-Blackwell on behalf of American Geophysical Union (AGU).
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  • 7
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    Soot Reactivity in Conventional Combustion and Oxy-fuel Combustion Environments (2012)
    American Chemical Society (ACS)
    Details
    Publication Date: 2012-07-22
    Description: Energy & Fuels DOI: 10.1021/ef300670q
    Print ISSN: 0887-0624
    Electronic ISSN: 1520-5029
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering , Process Engineering, Biotechnology, Nutrition Technology
    Published by American Chemical Society (ACS)
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  • 8
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    Release of Chlorine and Sulfur during Biomass Torrefaction and Pyrolysis (2014)
    American Chemical Society (ACS)
    Details
    Publication Date: 2014-06-08
    Description: Energy & Fuels DOI: 10.1021/ef4021262
    Print ISSN: 0887-0624
    Electronic ISSN: 1520-5029
    Topics: Chemistry and Pharmacology , Energy, Environment Protection, Nuclear Power Engineering , Process Engineering, Biotechnology, Nutrition Technology
    Published by American Chemical Society (ACS)
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  • 9
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    Persistence of DNMT3A mutations at long-term remission in adult patients with AML (2014)
    Wiley-Blackwell
    Details
    Publication Date: 2014-08-05
    Description: Mutations in DNMT3A , the gene encoding DNA methyltransferase 3 alpha, have been identified as molecular drivers in acute myeloid leukaemia (AML) with possible implications for minimal residual disease monitoring and prognosis. To further explore the utility of DNMT3A mutations as biomarkers for AML, we developed assays for sensitive detection of recurrent mutations affecting residue R882. Analysis of DNA from 298 diagnostic AML samples revealed DNMT3A mutations in 45 cases (15%), which coincided with mutations in NPM1 , FLT3 and IDH1 . DNMT3A mutations were stable in 12 of 13 patients presenting with relapse or secondary myelodysplastic syndrome, but were also present in remission samples from 14 patients (at allele frequencies of 〈1–50%) up to 8 years after initial AML diagnosis, despite the loss of all other molecular AML markers. The mutant DNMT3A allele burden was not related to the clinical course of disease. Cell sorting demonstrated the presence of DNMT3A mutations in leukaemic blasts, but also at lower allele frequencies in T and B-cells from the same patients. Our data are consistent with the recent finding of preleukaemic stem cells in AML, which are resistant to chemotherapy. The persistence of DNMT3A mutations during remission may have important implications for the management of AML.
    Print ISSN: 0007-1048
    Electronic ISSN: 1365-2141
    Topics: Medicine
    Published by Wiley-Blackwell
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  • 10
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    A prospective study of twinning and perinatal mortality in urban Guinea-Bissau (2012)
    BioMed Central
    Details
    Publication Date: 2012-12-06
    Description: Background: Despite twinning being common in Africa, few prospective twin studies have been conducted. We studied twinning rate, perinatal mortality and the clinical characteristics of newborn twins in urban Guinea-Bissau. Methods: The study was conducted at the Bandim Health Project (BHP), a health and demographic surveillance site in Bissau, the capital of Guinea-Bissau. The cohort included all newborn twins delivered at the National Hospital Simao Mendes and in the BHP study area during the period September 2009 to August 2011 as well as singleton controls from the BHP study area. Data regarding obstetric history and pregnancy were collected at the hospital. Live children were examined clinically. For a subset of twin pairs zygosity was established by using genetic markers. Results: Out of the 5262 births from mothers included in the BHP study area, 94 were twin births, i.e. a community twinning rate of 18/1000. The monozygotic rate was 3.4/1000. Perinatal mortality among twins vs. singletons was 218/1000 vs. 80/1000 (RR = 2.71, 95% CI: 1.93-3.80). Among the 13783 hospital births 388 were twin births (28/1000). The hospital perinatal twin mortality was 237/1000.Birth weight 〈 2000g (RR = 4.24, CI: 2.39-7.51) and caesarean section (RR = 1.78, CI: 1.06-2.99) were significant risk factors for perinatal twin mortality. Male sex (RR = 1.38, CI: 0.97-1.96), unawareness of twin pregnancy (RR = 1.64, CI: 0.97-2.78) and high blood pressure during pregnancy (RR = 1.77, CI: 0.88-3.57) were borderline non-significant. Sixty-five percent (245/375) of the mothers who delivered at the hospital were unaware of their twin pregnancy. Conclusions: Twins had a very high perinatal mortality, three-fold higher than singletons. A birth weight 〈 2000g was the strongest risk factor for perinatal death, and unrecognized twin pregnancy was common. Urgent interventions are needed to lower perinatal twin mortality in Guinea-Bissau.
    Electronic ISSN: 1471-2393
    Topics: Medicine
    Published by BioMed Central
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