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  • 1
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    Empirical modeling of plasma-sheet pressure and three-dimensional force-balanced magnetospheric magnetic field structure: 1. Observation (2013)
    Wiley-Blackwell
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    Publikationsdatum: 2013-09-25
    Beschreibung: [1]  A three-dimensional (3D) magnetic field configuration in force balance with a realistic plasma pressure distribution can provide more accurate evaluation of the role of magnetic field on plasma sheet dynamics and M-I coupling. We used Geotail and THEMIS data to establish an empirical model for nightside equatorial isotropic plasma pressure to r  = 30 R E for Kp = 0–5 and for solar wind dynamic pressure (P SW ) = 1.5 and 3 nPa. The model pressure is used in the companion paper for modeling a 3D force-balanced pressure and magnetic field equilibrium. Larger convection during higher Kp drives the plasma sheet further earthward, resulting in larger increase of pressure and pressure gradient at smaller radial distance. On the other hand, magnetosphere compression by increasing P SW enhances pressure and pressure gradient mainly in the tail plasma sheet. While both pressure and radial gradients are enhanced with increasing Kp or P SW , there is no significant azimuthal pressure variation statistically under all Kp and P SW conditions. The empirical pressures well reproduce these statistical profiles with very high correlation coefficients. Additionally, comparisons with pressure gradients computed using two simultaneous measurements from two THEMIS spacecraft show reasonable agreement. Furthermore, our model provides more accurate pressure gradients than previous empirical models. The model magnetic field distributions obtained in the companion paper from requiring force balance with these empirical pressure profiles are also found to be consistent with the magnetic field observations, indicating that our equilibria well represent realistic 3D pressure and magnetic field configurations.
    Print ISSN: 0148-0227
    Thema: Geologie und Paläontologie , Physik
    Publiziert von Wiley-Blackwell im Namen von American Geophysical Union (AGU).
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  • 2
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    catena-Poly[[[diaqua[3-(pyridin-4-yl)benzoato-κ2O,O′]terbium(III)]-bis[μ-3-(pyridin-4-yl)benzoato-κ2O:O′]] monohydrate] (2012)
    Wiley-Blackwell
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    Publikationsdatum: 2012-11-13
    Beschreibung: In the title compound, {[Tb(C 12 H 8 NO 2 ) 3 (H 2 O) 2 ]·H 2 O} n , the Tb III cation is in an eight-coordinate environment, ligated by six carboxylate O atoms from five 3-(pyridin-4-yl)benzoate ( L ) ligands and by two O atoms from water molecules. The cations are bridged by the carboxylate O atoms of the L ligands to form a two-stranded polymeric chain which is assembled into a three-dimensional supramolecular network through regular interchain O—H...N hydrogen bonding. On excitation at 320 nm, the title compound displays a series of emissions, which were assigned to the characteristic electronic transitions of Tb III .
    Print ISSN: 0108-2701
    Digitale ISSN: 1600-5759
    Thema: Chemie und Pharmazie , Geologie und Paläontologie , Physik
    Publiziert von Wiley-Blackwell im Namen von International Union of Crystallography (IUCr).
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  • 3
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    First experience of high intensity focused ultrasound combined with transcatheter arterial embolization as local control for hepatoblastoma (2013)
    Wiley-Blackwell
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    Publikationsdatum: 2013-06-29
    Beschreibung: Objective: The purpose of this study was to assess the effectiveness of high-intensity focused ultrasound (HIFU) combined with transarterial chemoembolization (TACE) in treating pediatric hepatoblastoma. Methods: 12 patients with initially unresectable hepatoblastoma were enrolled in the study. All patients received chemotherapy, TACE and HIFU ablation. Follow-up materials were obtained in all patients. The tumor response, survival rate and complication were analyzed. Results: Completely ablation was achieved in 10 patients (83.3%), and the AFP level was also decreased to normal in these patients. The mean follow-up time was 13.3±1.8 months (range, 2-25 months). At the end of follow-up, 2 patients died from tumor progression, the rest 10 patients were alive. One patient was found to have lung metastasis after HIFU and had an operation to remove the lesion. The median survival time was 14 months, and the survival rates of 1, 2-year were 91.7% and 83.3%, respectively. Complication included fever, transient impairment of hepatic function and mild malformation of rib. Conclusion: HIFU combined with TACE is a safe and promising method with a low rate of severe complications. As a non-invasive approach, it may provide a novel locally therapy for patients with unresectable hepatoblastoma. (H EPATOLOGY 2013.)
    Print ISSN: 0270-9139
    Digitale ISSN: 1527-3350
    Thema: Medizin
    Publiziert von Wiley-Blackwell im Namen von The American Association for the Study of Liver Diseases.
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  • 4
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    Combination of radiofrequency ablation and sequential cellular immunotherapy improves progression-free survival for patients with hepatocellular carcinoma (2013)
    Wiley-Blackwell
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    Publikationsdatum: 2013-07-04
    Beschreibung: Hepatocellular carcinoma (HCC) recurs frequently after minimally invasive therapy. This study was to observe the efficiency and safety of the combined treatment of radiofrequency ablation (RFA) with cellular immunotherapy (CIT) for HCC patients. In this study, sixty-two patients with HCC who were treated with radical RFA were divided into two groups: RFA alone (32 patients) and RFA/CIT (30 patients). Autologous mononuclear cells were collected from the peripheral blood and separated by apheresis, and then induced into natural killer (NK) cells, γδT cells and cytokine-induced killer (CIK) cells. These cells were identified by flow cytometry with their specific antibodies and then were infused intravenously to RFA/CIT patients for 3 or 6 courses. The tumor recurrent status of these patients was evaluated with computed tomography (CT) or magnetic resonance imaging (MRI) every 3 months after RFA. Progression-free survival (PFS), liver function, viral load, and adverse effects were examined. The results implied that PFS was higher in RFA/CIT group than that in RFA group. In RFA/CIT group, six courses had better survival prognosis than three courses. Viral load of hepatitis C was decreased in two of three patients without antiviral therapy in RFA/CIT group, but was increased in RFA group. No significant adverse reaction was found in the patients with CIT. In summary, these preliminary results suggest that combination of sequential CIT with RFA for HCC patients was efficient and safe, and may be helpful in the prevention of the recurrence for the patients with HCC after RFA. © 2013 Wiley Periodicals, Inc.
    Print ISSN: 0020-7136
    Digitale ISSN: 1097-0215
    Thema: Biologie , Medizin
    Publiziert von Wiley-Blackwell
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  • 5
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    Novel protein pp3501 mediates the inhibitory effect of sodium butyrate on SH-SY5Y cell proliferation (2012)
    Wiley-Blackwell
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    Publikationsdatum: 2012-04-16
    Beschreibung: Sodium butyrate, a new potential therapeutic drug, improves the efficacy of chemo- and immunotherapy of cancer under unknown mechanisms. A novel gene pp3501 is significantly induced in SH-SY5Y neuroblastoma cells upon sodium butyrate treatment. Therefore, this study has cloned pp3501 cDNA by RT-PCR and generated its recombinant fusion protein and anti-serum subsequently. The pp3501 protein localized mainly in the nucleus, as detected by immunocytochemistry and the expression of pp3501-EGFP fusion protein. pp3501 inhibited the proliferation of SH-SY5Y cells, arrested the cell cycle at G1 phase, and sensitized the SH-SY5Y cells to sodium butyrate treatment. These results provide a new mechanism of sodium butyrate inhibiting cancer cell proliferation as well as a new avenue for the future research on the functions of pp3501. J. Cell. Biochem. © 2012 Wiley Periodicals, Inc.
    Digitale ISSN: 0091-7419
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Publiziert von Wiley-Blackwell
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  • 6
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    Genome-wide screening revealed that miR-195 targets the TNF-α/NF-κB pathway by downregulating IKKα and TAB3 in hepatocellular carcinoma (2013)
    Wiley-Blackwell
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    Publikationsdatum: 2013-03-12
    Beschreibung: NF-κB is an important factor linking inflammation and tumorigenesis. In this study, we experimentally demonstrated through a high-throughput luciferase reporter screen that NF-κB signaling can be directly targeted by nearly 29 microRNAs (miRNAs). Many of these miRNAs can directly target NF-κB signaling nodes by binding to their 3′ UTRs. miR-195, a member of miR-15 family, is frequently downregulated in gastrointestinal cancers, especially in hepatocellular carcinoma (HCC). Expression level of miR-195 is inversely correlated with HCC tumor size. We further show that miR-195 suppresses cancer cell proliferation and migration in vitro and reduces tumorigenicity and metastasis in vivo. Additionally, miR-195 may exert its tumor suppressive function by decreasing the expression of multiple NF-κB downstream effectors via the direct targeting of IKKα and TAB3. Conclusion: Our findings indicate that multiple miRNAs are involved in the NF-κB signaling pathway and that miR-195 plays important inhibitory roles in cancer progression and may be a potential therapeutic target. (H EPATOLOGY 2013.)
    Print ISSN: 0270-9139
    Digitale ISSN: 1527-3350
    Thema: Medizin
    Publiziert von Wiley-Blackwell im Namen von The American Association for the Study of Liver Diseases.
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  • 7
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    The growth and spectral analysis of mixed crystal of Yb-doped Lu0.5Y0.5PO4 mixed crystals (2014)
    Wiley-Blackwell
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    Publikationsdatum: 2014-11-26
    Beschreibung: A new kind of 5 at% Yb-doped Lu 0.5 Y 0.5 PO 4 crystals were firstly grown by spontaneously nucleated high-temperature solution method using lead pyrophosphate (Pb 2 P 2 O 7 ) as the solvent. The X-ray powder diffraction (XRPD) patterns recorded at room temperature showed the crystals possessed tetragonal xenotime structure. The polarized absorption spectra and the fluorescence spectra of Yb:Lu x Y 1-x PO 4 were measured at room temperature, respectively. The results show that Yb:Lu x Y 1-x PO 4 mixed crystal will be a promising laser material if the crystal size and quality is further improved. A new kind of 5 at% Yb-doped Lu 0.5 Y 0.5 PO 4 crystals were firstly grown by spontaneously nucleated high-temperature solution method using lead pyrophosphate (Pb 2 P 2 O 7 ) as the solvent. The X-ray powder diffraction (XRPD) patterns recorded at room temperature showed the crystals possessed tetragonal xenotime structure. The polarized absorption spectra and the fluorescence spectra of Yb:Lu x Y 1-x PO 4 were measured at room temperature, respectively. The results show that Yb:Lu x Y 1-x PO 4 mixed crystal will be a promising laser material if the crystal size and quality is further improved.
    Print ISSN: 0232-1300
    Digitale ISSN: 1521-4079
    Thema: Geologie und Paläontologie , Physik
    Publiziert von Wiley-Blackwell
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  • 8
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    Experimental investigation and numerical simulation of marangoni effect induced by mass transfer during drop formation (2013)
    Wiley-Blackwell
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    Publikationsdatum: 2013-06-02
    Beschreibung: Marangoni effect induced by interphase mass transfer plays an important role in liquid-liquid extraction and reaction processes. The interaction of Marangoni effect and interphase mass transfer during drop formation at different injection rates and different initial solute concentrations was investigated by experiment and numerical simulation. The extraction fraction was measured and the corresponding correlation was proposed. The level set method coupled with mass transfer equation is for the first time used to simulate the mass transfer induced Marangoni effect during drop formation. The simulated drop volume, shape and extraction fraction are in good accordance with experimental data. Through the numerical simulation, it is found that the mass transfer in the first mass transfer period is the most efficient during drop formation when Marangoni convection occurs. © 2013 American Institute of Chemical Engineers AIChE J, 2013
    Print ISSN: 0001-1541
    Digitale ISSN: 1547-5905
    Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Publiziert von Wiley-Blackwell im Namen von The American Institute of Chemical Engineers (AIChE).
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  • 9
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    Effect of injection zone cracking on fluid catalytic cracking (2012)
    Wiley-Blackwell
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    Publikationsdatum: 2012-08-08
    Beschreibung: Fluid catalytic cracking (FCC) is a refining process for converting heavy oils to valuable products such as gasoline and olefins. Modeling of this process is quite challenging. A common assumption has been that vaporization is instantaneously fast and cracking is negligible in the injection zone. Relaxing this assumption, here we develop an approach for quantifying the effect of injection zone cracking on FCC performance. The approach combines a Lagrangian description of the spray behavior with an Eulerian modeling of transport-cracking coupling in the FCC riser. Included in the model are droplet vaporization, a four-lump kinetic network, spray penetration trajectory, solid-fluid and solid-solid collisions, and multi-spray interactions. Parametric studies show that precracking in the injection zone plays an important role in steering the overall performance of an FCC riser. The model developed here can accommodate a large number of reactions, thus allowing for composition-based modeling of the FCC process. © 2012 American Institute of Chemical Engineers AIChE J, 2012
    Print ISSN: 0001-1541
    Digitale ISSN: 1547-5905
    Thema: Chemie und Pharmazie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Publiziert von Wiley-Blackwell im Namen von The American Institute of Chemical Engineers (AIChE).
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  • 10
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    HER2-positive patients receiving trastuzumab treatment have a comparable prognosis with HER2-negative advanced gastric cancer patients: A prospective cohort observation (2013)
    Wiley-Blackwell
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    Publikationsdatum: 2013-10-25
    Beschreibung: The monoclonal antibody trastuzumab has brought survival benefit to patients with advanced gastric cancer (AGC) that have human epidermal growth factor receptor 2 (HER2) over expression or amplification. This study was designed to compare the clinical outcomes of HER2-negative and HER2-positive AGC patients with or without trastuzumab treatment. There were three groups of patients enrolled for analysis. Group A was 51 HER2-positive AGC patients treated with trastuzumab and chemotherapy; group B was a matched control group of 47 HER2-positive patients who received chemotherapy only; group C was a matched group of 251 HER2-negative patients who received chemotherapy. All the patients were enrolled at Sun Yat-sen University Cancer Center or Zhongshan Hospital, Fudan University between January 2010 and December 2012. The primary endpoint was overall survival (OS). The Kaplan-Meier method and log-rank test were used for survival analysis. The median duration of follow-up was 13.5 months (range, 5-18.6 months). The median OS of these three groups of patients was 14.8 months, 11.3 months and 14.4 months respectively (P〈0.001). The survival difference between group A and B was significant, P〈0.001. Similarly, there was significant difference between group B and C, P〈0.001. Moreover the survival between group A and C was comparable, P=0.281. The median progression free survival for these three groups was 7.4, 6.0 and 7.2 months. Multivariate analysis confirmed that trastuzumab treatment was an independent prognostic factor in group A and B patients (P=0.017). HER2 positive was an independent adverse prognostic factor in group B and C patients (P=0.013). © 2013 Wiley Periodicals, Inc.
    Print ISSN: 0020-7136
    Digitale ISSN: 1097-0215
    Thema: Biologie , Medizin
    Publiziert von Wiley-Blackwell
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