Publication Date:
2011-01-22
Description:
Five new oxygenated lignans with a dibenzocyclooctadiene skeleton, kadsuphilols P–T ( 1 – 5 ), and two new C 19 homolignans, kadsuphilols U and V ( 6 and 7 ), were isolated by chromatographic fractionation of an AcOEt extract of the stems of Kadsura philippinensis. The structures of the isolated metabolites were elucidated through extensive spectroscopic analysis including HR-ESI-MS and 2D-NMR (HMQC, COSY, and HMBC). The configuration at the chiral centers and at the biphenyl moiety were determined by interpretation of NOESY and CD data, respectively.
Print ISSN:
0018-019X
Electronic ISSN:
1522-2675
Topics:
Chemistry and Pharmacology
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