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  • 2010-2014  (87)
  • 1990-1994  (4)
  • 1975-1979  (3)
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  • 1
    Electronic Resource
    Electronic Resource
    Hypersensitivity pneumonitis induced by Penicillium expansum in a home environment (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 24 (1994), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: An episode of fever, cough, shortness of breath and leucocytosis developed in a 31-year-old atopic housewife from mould exposure in her home environment is evaluated. A chest radiograph revealed diffuse tiny nodular infiltrations in both whole lung fields. Spirometry revealed a severe restrictive type of ventilation impairment. Bronchoalveolar lavage (BAL) showed an increased lymphocyte count with reversed CD4 +/CD8 + ratio and transbronchial lung biopsy showed markedly increased lymphocytic infiltration in alveolar septa. Fungal cultures in the air of her home were positive for Penicillium expansum and other fungi. Double immunodiffusion test with the patient's serum showed two precipitin bands to P. expansum antigens. Her symptoms, abnormal findings of radiograph, and spirometric abnormalities disappeared after 2 months' avoidance. The serum precipitin disappeared after 1 month's avoidance. This study indicates that the patient had hypersensitivity pneumonitis (HP) on exposure to P. expansum in her home environment.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1994.tb00251.x
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  • 2
    Electronic Resource
    Electronic Resource
    In vitro study of contact area and pressure distribution in the human knee after partial and total meniscectomy (1993)
    Springer
    International orthopaedics 17 (1993), S. 214-218 
    Details
    ISSN: 1432-5195
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Résumé Nombre de travaux ont été effectués récemment afin d'expliquer l'évolution vers l'arthrose après méniscectomie. Les modifications mécaniques entraînant une concentration des contraintes sont considérées comme une des causes majeures. Mais il n'y a que peu d'études expérimentales concernant les différences de pression sur la surface de contact et le type de distribution des contraintes après méniscectomie partielle ou totale. En utilisant un film sensible à la pression (Pressensor) nous avons pu mesurer la surface de contact et son type de distribution dans les trois situations: ménisque intact, méniscectomie partielle et méniscectomie totale. Le matériel d'expérimentation consistait en cinq pièces d'amputation de cuisse. Pendant l'expérimentation le genou était placé en extension complète et fixé à la machine Instrom par une barre d'aluminium et une monture de résine. La charge était transmise par la machine à l'articulation fémoro-tibiale et au film Pressensor pré-inséré, dans les limites physiologiques. L'analyse de la surface de contact dans les trois situations a été permise par l'examen du film. En mesurant la surface de contact après méniscectomie nous avons montré que la fonction du ménisque est d'assurer la transmission des charges et l'absorption d'énergie dans le genou. La comparaison de la surface de contact interne de l'articulation avec la surface de contact externe montre que, lorsque le ménisque est intact, la première est toujours plus étendue que la seconde (le rapport est de 1.36). La différence diminue légérement en cas de méniscectomie partielle et beaucoup plus après méniscectomie totale. Le degré de concentration des contraintes augmente selon que le ménisque est intact, partiellement ou totalement réséqué. Il n'y a que de minimes modifications de la surface de contact du côté opposé de l'articulation après méniscectomie partielle, mais elles sont importantes après méniscectomie totale.
    Notes: Summary Many investigators have attempted to find the cause of the osteoarthritic changes after meniscectomy. Alteration of the mechanical factors resulting in stress concentration, is now thought to be one of the most important causes but few experimental studies have reported the differences in contact area and pressure distribution after partial or total meniscectomy. By using pressure sensitive film, we have calculated the contact area and the pattern of weight distribution in three different situations; intact meniscus, partial and total meniscectomy. The experimental materials were obtained from 5 above knee amputation specimens. The knee joint was fixed in full extension to an Instron machine using an aluminium box and mounting resin. Load was transmitted to the tibiofemoral joint containing the special film, within a physiological range. Analysis of the contact area for each situation (intact meniscus, partial and total meniscectomy) was made by reviewing the film, By measuring the contact area after meniscectomy, we showed that the meniscus performs a load transmitting function in the knee joint. The medial contact area of the tibiofemoral joint with an intact meniscus is always larger than the lateral compartment (1.36:1), but in partial and total meniscectomy the difference between them gradually decreased. There was a minor decrease in contact area after partial meniscectomy and a much greater decrease after total meniscectomy. The degree of stress concentration in the contact area was increased when part or all the meniscus was excised. There was little change of contact area in the opposite, intact side of the joint after partial meniscectomy, but marked change after total meniscectomy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00194181
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  • 3
    Electronic Resource
    Electronic Resource
    Darstellung eines neuen Polyoxims und reversible Aufnahme von O2 und CO durch dessen Metallkomplexe (1976)
    Springer
    Colloid & polymer science 254 (1976), S. 763-763 
    Details
    ISSN: 1435-1536
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01643883
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  • 4
    Electronic Resource
    Electronic Resource
    Aktivität eines neuen Polyoxim-Cu-Komplexes bei der reversiblen Aufnahme von O2 und CO bei der Polymerisation von Acrylnitril und bei der Additionsreaktion von Alkoholen an Acrolein (1977)
    Springer
    Colloid & polymer science 255 (1977), S. 721-721 
    Details
    ISSN: 1435-1536
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01550188
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  • 5
    Electronic Resource
    Electronic Resource
    Untersuchung der reversiblen Aufnahme von CO, der katalytischen Hydrierung, der Reaktionen mit Benzylhalogeniden und des reproduzierbaren Auftretens eines ESR-Signals durch einen neuen Polyoxim-Pd-Komplex (1977)
    Springer
    Colloid & polymer science 255 (1977), S. 727-727 
    Details
    ISSN: 1435-1536
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01550229
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  • 6
    Electronic Resource
    Electronic Resource
    Paracrine factors and the regulation of spermatogenesis (1993)
    Springer
    World journal of urology 11 (1993), S. 120-128 
    Details
    ISSN: 1433-8726
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Main problem: Although the gonadotropins and testosterone are required for normal spermatogenesis, it is believed that local control factors regulate spermatogenesis. For many years these regulatory factors had not been identified. Over the past five years, a number of growth factors have been identified in testis or isolated testicular cell types or secretions. Growth factors are key regulatory molecules which affect cell proliferation, meiosis, and differentiated function. These factors usually act in an autocrine (acting upon the cell which secreted it) or paracine (affecting another cell) manner and thus are involved in intercellular communications. Methods: Growth factor secretion by testicular cell types or testis tissue has been analyzed using a variety of assays measuring cell proliferation in vitro, as well as assays using immunocytochemicals. Growth factor gene expression in testis has been analyzed by Northern blot analysis and in situ hybridization, which gives information concerning the stage and cell specific expression of the gene. Inbred strains of mice with mutations or deletions in a growth factor gene has been used to suggest the function of two specific factors in testicular development and growth. Results: Among the growth factors expressed or secreted by testicular cell types, most are common to some other cell types in the body, such as transforming growth factors alpha and beta, epidermal growth factor, fibroblast-like growth factors, insulin-like growth factors, interleukins, endorphins, inhibin and activin, while others may be more testis specific such as mullerian inhibiting substance (anti-mullerian hormone) and Sertoli cell secreted growth factor. A variety of proto-oncogenes are expressed at discrete stages of spermatogenesis, as well as by the somatic cells of the testis. Many of these encode growth factors, receptors or other proteins involved in signal transduction. Conclusion: With the exception of the kit ligand and the c-kit proto-oncogene, which have been demonstrated to play a role in the survival of the primordial germ cell in the testis during embryogenesis, little is known of the direct role of the other growth factors in spermatogenesis. It is likely that in the near future that the function of many of these proteins in the regulation of spermatogenesis will be identified. Eventually, this information will be used to develop specific therapies and diagnostic procedures for the infertile male.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00182039
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  • 7
    Electronic Resource
    Electronic Resource
    Kinematics and deformation characteristics as a mixing measure in the screw extrusion process (1994)
    Stamford, Conn. [u.a.] : Wiley-Blackwell
    Polymer Engineering and Science 34 (1994), S. 174-189 
    Details
    ISSN: 0032-3888
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The present paper proposes “Deformation Characteristics” (DC) as a new deformation measure of screw extrusion processes, based on the Green deformation tensor. In contrast to previous strain measures heuristically proposed by Mohr, et al., Mckelvey, and Pinto and Tadmor, the new DC can naturally incorporate the demixing phenomena and systematically take into account the three-dimensional circulatory flow with the screw flight effect. Therefore, DC can be regarded as an improved strain measure. “Weighted Average Deformation characteristics” (WADC) is also proposed to indicate the overall deformation characteristics as a quantitative measure to the “goodness of mixing” of the extrusion process. The present paper includes discussion on delicate differences between DC and several other strain measures in case of the two-dimensional velocity approximation, and on the application of DC into a general three-dimensional velocity field obtained by a quasi-three-dimensional finite element analysis of extrusion processes. In determining WADC in the three-dimensional application, the residence time distribution function, including the three-dimensional circulatory flow effect, is used.
    Additional Material: 15 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pen.760340303
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  • 8
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    Incidental Diffuse Thyroid 18F-FDG Uptake Related to Autoimmune Thyroiditis May Be a Favorable Prognostic Factor in Advanced Breast Cancer (2012)
    The Society of Nuclear Medicine (SNM)
    Details
    Publication Date: 2012-12-01
    Description: Patients with breast cancer have a relatively high prevalence of diffuse thyroid uptake of 18 F-FDG related to thyroid autoimmunity. It is postulated that the presence of thyroid autoimmunity has prognostic implications for breast cancer. The aim of this study was to evaluate the prognostic value of incidental diffuse thyroid uptake in breast cancer patients. Methods: This was a retrospective observational cohort study in a tertiary referral hospital. We evaluated a total of 564 patients who had undergone surgery for primary breast cancer between January 2006 and December 2009. Patients were divided into 2 groups according to their diffuse thyroid uptake. The main outcome measure was disease-free survival. Results: Of the 564 patients, 108 (19.1%) showed diffuse thyroid uptake. The median follow-up period was 36.0 mo (range, 1.0–77.0 mo). Both thyroperoxidase and thyroglobulin antibody titers were higher in patients with thyroid uptake than in those without ( P 〈 0.001 for both). Of the 108 patients with thyroid uptake, 5 had a recurrence of breast cancer during the follow-up, whereas 85 without uptake had a recurrence (log-rank statics, 12.28; P 〈 0.001). The association between diffuse thyroid uptake and tumor recurrence was not significant in multivariate analysis of patients with early-stage breast cancer (hazard ratio, 0.26; 95% confidence interval, 0.06–1.10; P = 0.067). However, the association between diffuse thyroid uptake and breast cancer recurrence was statistically significant in multivariate analysis with adjustment for several prognostic variables (hazard ratio, 0.19; 95% confidence interval, 0.57–0.62; P = 0.006). Conclusion: Incidental diffuse thyroid uptake related to autoimmune thyroiditis was an independently favorable prognostic factor in advanced breast cancer. These findings support evidence that thyroid autoimmunity has a beneficial effect on the outcomes of breast cancer patients.
    Print ISSN: 0022-3123
    Topics: Medicine
    Published by The Society of Nuclear Medicine (SNM)
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  • 9
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    Metformin Regulates GLUT4 via AMPK [Gene Regulation] (2012)
    The American Society for Biochemistry and Molecular Biology (ASBMB)
    Details
    Publication Date: 2012-12-29
    Description: Metformin is a leading oral anti-diabetes mellitus medication and is known to stimulate GLUT4 translocation. However, the mechanism by which metformin acts is still largely unknown. Here, we showed that short time treatment with metformin rapidly increased phosphorylation of Cbl in an AMP-activated protein kinase (AMPK)-dependent fashion in 3T3-L1 preadipocytes. Metformin also increased phosphorylation of Src in an AMPK-dependent manner. Src inhibition blocked metformin-mediated Cbl phosphorylation, suggesting that metformin stimulates AMPK-Src-Cbl axis pathway. In addition, long term treatment with metformin stimulated the expression of Cbl-associated protein (CAP) mRNA and protein. Long term treatment with metformin stimulated phosphorylation of c-Jun N-terminal kinase (JNK) and its downstream molecule c-Jun, which is a critical molecule for CAP transcription. Knockdown of AMPK and JNK blocked metformin-induced expression of CAP, implying that metformin stimulates AMPK-JNK-CAP axis pathway. Moreover, AMPK knockdown attenuated metformin-induced Cbl/CAP multicomplex formation, which is critical for GLUT4 translocation. A colorimetric absorbance assay demonstrated that metformin-induced translocation of GLUT4 was suppressed in CAP or Cbl knockdown cells. Furthermore, the promoter activity of CAP was increased by metformin in an AMPK/JNK-dependent fashion. In summary, these results demonstrate that metformin modulates GLUT4 translocation by regulating Cbl and CAP signals via AMPK.
    Print ISSN: 0021-9258
    Electronic ISSN: 1083-351X
    Topics: Biology , Chemistry and Pharmacology
    Published by The American Society for Biochemistry and Molecular Biology (ASBMB)
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  • 10
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    FOXO1 impairs whereas statin protects endothelial function in diabetes through reciprocal regulation of Kruppel-like factor 2 (2012)
    Oxford University Press
    Details
    Publication Date: 2012-12-22
    Description: Aims Krüppel-like factor 2 (KLF2) is implicated as a key molecule maintaining endothelial function. This study was designed to evaluate the reciprocal regulation of KLF2 by the forkhead transcription factor FOXO1, and the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor atorvastatin, in hyperglycaemic conditions. Methods and results Exposure of human umbilical vein endothelial cells to 30 mM glucose activated FOXO1 and suppressed KLF2. These effects were reversed by FOXO1 small interfering RNA. Adenoviral transfection of constitutively active FOXO1 suppressed KLF2 expression. Interestingly, atorvastatin inhibited FOXO1 by increasing phosphorylation and also by inhibiting nuclear localization and replenished KLF2 in high-glucose conditions. This effect of atorvastatin was attenuated by mevalonate. Chromatin immunoprecipitation analysis demonstrated that glucose increased whereas atorvastatin decreased FOXO1 binding to the promoter region of the KLF2 gene. In the vessels of Otsuka Long-Evans Tokushima Fatty rats, animal models of type 2 diabetes, FOXO1 was activated and KLF2 was suppressed, and this was reversed by atorvastatin treatment. The arteries from Otsuka Long-Evans Tokushima Fatty rats showed impairment of endothelium-dependent vasodilatation, and both atorvastatin and KLF2 gene therapies restored it. Conclusions Suppression of KLF2 by FOXO1 may be a plausible mechanism of diabetic endothelial dysfunction. High-glucose-induced, FOXO1-mediated KLF2 suppression was reversed by atorvastatin, suggesting that intensive statin treatment could be a therapeutic option in diabetic vascular dysfunction.
    Print ISSN: 0008-6363
    Electronic ISSN: 1755-3245
    Topics: Medicine
    Published by Oxford University Press
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