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  • 2010-2014  (41)
  • 2000-2004  (1)
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  • 1
    Electronic Resource
    Electronic Resource
    A pilot trial assessing the efficacy of paroxetine hydrochloride (Paxil®) in controlling hot flashes in breast cancer survivors (2000)
    Springer
    Annals of oncology 11 (2000), S. 17-22 
    Details
    ISSN: 1569-8041
    Keywords: breast cancer ; hot flashes ; paroxetine ; serotonin uptake inhibitors ; survivors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background:Many breast cancer survivors suffer debilitating hotflashes. Estrogen, the drug of choice in perimenopausal women, is generallynot recommenced to breast cancer survivors. Nonhormonal treatments are mostlydisappointing. Anecdotal reports in our institution suggested that theselective serotonin-reuptake inhibitor, paroxetine hydrochloride, might beefficacious in alleviating hot flashes. Patients and methods:Thirty women with prior breast cancer whowere suffering at least two hot flashes a day entered a single institutionpilot trial to evaluate paroxetine's efficacy in reducing the frequency andseverity of hot flashes. After completing daily diaries for one week on notherapy, the women received open-label paroxetine, 10 mg daily for one week,followed by four weeks of paroxetine, 20 mg daily. The women completedhot-flash daily diaries throughout the study period, and a health-relatedsymptom-assessment questionnaire and a quality-of-life rating scale in thefirst and sixth week of the study. Results:Twenty-seven women completed the six-week study period.The mean reduction of hot flash frequency was 67% (95%confidence interval (95% CI): 56%–79%). The meanreduction in hot flash severity score was 75% (95% CI:66%–85%). There was a statistically significantimprovement in depression, sleep, anxiety, and quality of life scores.Furthermore, 25 (83%) of the study participants chose to continueparoxetine therapy at the end of study. The most common adverse effect wassomnolence, resulting in drug discontinuation in two women, and dose reductionin two women. One woman discontinued drug due to anxiety. Conclusions:Paroxetine hydrochloride is a promising new treatmentfor hot flashes in breast cancer survivors, and warrants further evaluationin a double-blind randomized placebo-controlled trial.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1008382706068
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    Paper (German National Licenses)
    Fulltext
  • 2
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    Hindcast of oil-spill pollution during the Lebanon crisis in the Eastern Mediterranean, July–August 2006 (2012)
    Elsevier Science Limited
    Details
    Publication Date: 2021-06-25
    Description: MOON (Mediterranean Operational Oceanography Network http://www.moon-oceanforecasting.eu) provides near-real-time information on oil-spill detection (ocean color and SAR) and predictions [ocean forecasts (MFS and CYCOFOS) and oil-spill predictions (MEDSLIK)]. We employ this system to study the Lebanese oil-pollution crisis in summer 2006 and thus to assist regional and local decision makers in Europe, regionally and locally. The MEDSLIK oil-spill predictions obtained using CYCOFOS high-resolution ocean fields are compared with those obtained using lower-resolution MFS hydrodynamics, and both are validated against satellite observations. The predicted beached oil distributions along the Lebanese and Syrian coasts are compared with in situ observations. The oil-spill predictions are able to simulate the northward movement of the oil spill, with the CYCOFOS predictions being in better agreement with satellite observations. Among the free MEDSLIK parameters tested in the sensitivity experiments, the drift factor appears to be the most relevant to improve the quality of the results.
    Description: Published
    Description: 140–153
    Description: JCR Journal
    Description: restricted
    Keywords: Lebanese oil-pollution event; Oil-spill modeling; Operational oceanography; Remote sensing; Levantine Basin ; 03. Hydrosphere::03.02. Hydrology::03.02.99. General or miscellaneous
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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    PAPER (OA)
  • 3
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    Hindcast of Oil Spill Pollution during the Lebanon Crisis, July-August 2006 (2010)
    Details
    Publication Date: 2020-10-15
    Description: The Mediterranean Operational Oceanography Network (MOON ) provides near-real-time information on oil spill detection and predictions that have been used during the Lebanese oil pollution crisis in summer 2006. A MOON decision support system for oil spill monitoring and prediction comprising ocean colour satellite and SAR images, ocean current forecast (MFS-Mediterranean Forecasting System and CYCOFOS-CYprus Coastal Ocean Forecasting & Observing System) and the MEDSLIK oil spill model has been developed. The oil spill predictions obtained with MEDSLIK coupled to the CYCOFOS high-resolution ocean fields are compared with the oil spill predictions obtained using the lower resolution MFS hydrodynamics and both are validated against satellite observations. The predicted beached oil quatity along the Lebanese and Syrian coasts are compared with the in-situ observations. It is found that predictions with both CYCOFOS and MFS ar capable to simulate the northward movement of the oil, with the higher resolution CYCOFOS predictions in better agreement with satellite observations. Among the free MEDSLIK oil spill parameters tested in the sensitivity experiments there are the wind corrections (wind factor and angle) and the depth of coupling between eulerian fields and wind correction. Among them the drift factor appeared the most relevant in order to improve the quality of results suggesting that operational models such as MFS and CYCOFOS still lack of enought resolution and physical process at the air-sea interface. The oil moved from Lat 33°40'N Lon 35°24.75'E northward toward Syria, which was reached in 10 days at Lat 34° 38.451'N Lon 35° 58.377'E; the oil movement is followed up to August 6 when the oil reached 35.5°N.
    Description: Not submitted
    Description: 4.6. Oceanografia operativa per la valutazione dei rischi in aree marine
    Description: JCR Journal
    Description: open
    Keywords: Lebanese oil pollution event ; oil spill modelling ; operational oceanography ; remote sensing ; Levantine Basin ; 03. Hydrosphere::03.01. General::03.01.05. Operational oceanography
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: manuscript
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  • 4
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    Expert assessment of vulnerability of permafrost carbon to climate change (2013)
    In:  EPIC3Climatic Change, 119(2), pp. 359-374, ISSN: 0165-0009
    Details
    Publication Date: 2016-12-13
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
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  • 5
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    Hindcast of oil-spill pollution during the Lebanon crisis in the Eastern Mediterranean, July–August 2006 (2011)
    Elsevier
    Details
    Publication Date: 2017-04-04
    Description: MOON (Mediterranean Operational Oceanography Network http://www.moon-oceanforecasting.eu) pro- vides near-real-time information on oil-spill detection (ocean color and SAR) and predictions [ocean fore- casts (MFS and CYCOFOS) and oil-spill predictions (MEDSLIK)]. We employ this system to study the Lebanese oil-pollution crisis in summer 2006 and thus to assist regional and local decision makers in Europe, regionally and locally. The MEDSLIK oil-spill predictions obtained using CYCOFOS high-resolution ocean fields are compared with those obtained using lower-resolution MFS hydrodynamics, and both are validated against satellite observations. The predicted beached oil distributions along the Lebanese and Syrian coasts are compared with in situ observations. The oil-spill predictions are able to simulate the northward movement of the oil spill, with the CYCO- FOS predictions being in better agreement with satellite observations. Among the free MEDSLIK param- eters tested in the sensitivity experiments, the drift factor appears to be the most relevant to improve the quality of the results.
    Description: The paper was produced using the INGV MFS forecasting-sys- tem product and the OC-UCY CYCOFOS forecasting-system prod- ucts. The MODIS satellite data products were processed at the GOS-CNR-ISAC Rome laboratory using the SeaDAS software devel- oped by NASA GSFC, Greenbelt, Maryland, the HDFLook software developed by The Laboratoire d’Optique Atmosphérique, Univer- sity of Lille, France, and the MS2GT tool box developed by the Uni- versity of Colorado. Procedures for oil-spill detection were developed in the ENVI environment. Processed ENVISAT-ASAR data were made available by Telespazio and JRC. Part of this work was carried out with the support of the PRIMI project (ASI Contract No. I/094/06/0) financed by the Italian Space Agency (ASI).
    Description: In press
    Description: 4.6. Oceanografia operativa per la valutazione dei rischi in aree marine
    Description: JCR Journal
    Description: reserved
    Keywords: Lebanese oil-pollution event ; Oil-spill modeling ; Operational oceanography ; Remote sensing ; Levantine Basin ; 03. Hydrosphere::03.01. General::03.01.05. Operational oceanography
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 6
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    Expert assessment of vulnerability of permafrost carbon to climate change (2013)
    Springer
    In:  EPIC3Climatic Change, Springer, 119(2), pp. 359-374, ISSN: 0165-0009
    Details
    Publication Date: 2020-02-10
    Description: Approximately 1700 Pg of soil carbon (C) are stored in the northern circumpolar permafrost zone, more than twice as much C than in the atmosphere. The overall amount, rate, and form of C released to the atmosphere in a warmer world will influence the strength of the permafrost C feedback to climate change. We used a survey to quantify variability in the perception of the vulnerability of permafrost C to climate change. Experts were asked to provide quantitative estimates of permafrost change in response to four scenarios of warming. For the highest warming scenario (RCP 8.5), experts hypothesized that C release from permafrost zone soils could be 19–45 Pg C by 2040, 162–288 Pg C by 2100, and 381–616 Pg C by 2300 in CO2 equivalent using 100-year CH4 global warming potential (GWP). These values become 50 % larger using 20-year CH4 GWP, with a third to a half of expected climate forcing coming from CH4 even though CH4 was only 2.3 % of the expected C release. Experts projected that two-thirds of this release could be avoided under the lowest warming scenario (RCP 2.6). These results highlight the potential risk from permafrost thaw and serve to frame a hypothesis about the magnitude of this feedback to climate change. However, the level of emissions proposed here are unlikely to overshadow the impact of fossil fuel burning, which will continue to be the main source of C emissions and climate forcing.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
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  • 7
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    Gliders for Research, Ocean Observation and Management - GROOM (2012)
    In:  [Poster] In: Ocean Sciences Meeting 2012, 20.-24.02.2012, Salt Lake City, USA .
    Details
    Publication Date: 2012-11-29
    Type: Conference or Workshop Item , NonPeerReviewed , info:eu-repo/semantics/conferenceObject
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    OceanRep: Poster
  • 8
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    Gliders for Research, Ocean Observation and Management - GROOM (2013)
    In:  [Poster] In: Baltic Sea Science Congress 2013, 26.-30-08.2013, Klaipeda, Lithuania .
    Details
    Publication Date: 2014-01-09
    Type: Conference or Workshop Item , NonPeerReviewed , info:eu-repo/semantics/conferenceObject
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    OceanRep: Poster
  • 9
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    Gliders as a Component of Future Observing Systems (2010)
    OceanObs'09
    In:  In: Proceedings of the "OceanObs'09: Sustained Ocean Observations and Information for Society". , ed. by Hall, J., Harrison, D. E. and Stammer, D. ESA Publication, WPP-306 . OceanObs'09, Venice, Italy.
    Details
    Publication Date: 2012-07-06
    Type: Book chapter , NonPeerReviewed
    Format: text
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    OceanRep: Book chapter
  • 10
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    Gliders for Research, Ocean Observation and Management - GROOM (2012)
    In:  [Poster] In: EGU General Assembly 2012, 22.-27.04.2012, Vienna, Austria .
    Details
    Publication Date: 2012-11-29
    Type: Conference or Workshop Item , NonPeerReviewed , info:eu-repo/semantics/conferenceObject
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    OceanRep: Poster
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