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  • 1
    Electronic Resource
    Electronic Resource
    Reduced contribution from Na+/H+ exchange to acid extrusion during anoxia in adult rat hippocampal CA1 neurons (2004)
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 88 (2004), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The effect of anoxia on Na+/H+ exchange activity was examined in acutely isolated adult rat hippocampal CA1 neurons loaded with the H+-sensitive fluorophore, BCECF. Five-minute anoxia imposed under nominally HCO3–/CO2-free conditions induced a fall in pHi, the magnitude of which was smaller following prolonged exposure to medium in which N-methyl-d-glucamine (NMDG+) was employed as an extracellular Na+ (Na+o) substitute. Also consistent with the possibility that Na+/H+ exchange becomes inhibited soon after the induction of anoxia, rates of Na+o-dependent pHi recovery from internal acid loads imposed during anoxia were slowed, compared to rates of Na+o-dependent pHi recovery observed prior to anoxia. At the time at which rates of pHi recovery were reduced during anoxia, cellular adenosine triphosphate (ATP) levels had fallen to 35% of preanoxic levels, suggesting that ATP depletion might contribute to the observed inhibition of Na+/H+ exchange. In support, incubation of neurons with 2-deoxyglucose and antimycin A under normoxic conditions induced a fall in cellular ATP levels that was also associated with reduced Na+o-dependent rates of pHi recovery from imposed acid loads; conversely, pre-treatment with 10 mm creatine attenuated the effects of anoxia to reduce both ATP levels and Na+o-dependent rates of pHi recovery from internal acid loads. Taken together, the results are consistent with the possibility that functional Na+/H+ exchange activity in adult rat CA1 neurons declines soon after the onset of anoxia, possibly as a result of anoxia-induced falls in intracellular ATP.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1471-4159.2003.02169.x
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    Paper (German National Licenses)
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  • 2
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    U.S. Department of Agriculture Agricultural Research Service Mahantango Creek Watershed, Pennsylvania, United States: Long-term stream discharge database (2011)
    Wiley-Blackwell
    Details
    Publication Date: 2011-08-20
    Description: A long-term streamflow discharge database has been developed by the U.S. Department of Agriculture (USDA) Agricultural Research Service (ARS) Pasture Systems and Watershed Management Research Unit to support intensive hydrologic and water quality research within WE-38, a 7.3 km2 experimental subwatershed of Mahantango Creek Watershed located in east central Pennsylvania and draining to the Susquehanna River. Daily streamflow discharge data were collected at the outflow of WE-38 from 1968 to 2007, producing a 40 year record of streamflow. Data are available on USDA ARS's Sustaining the Earth's Watersheds—Agricultural Research Data System (STEWARDS) Web site.
    Print ISSN: 0043-1397
    Electronic ISSN: 1944-7973
    Topics: Architecture, Civil Engineering, Surveying , Geography
    Published by Wiley-Blackwell on behalf of American Geophysical Union (AGU).
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  • 3
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    Heritable genome editing in C. elegans via a CRISPR-Cas9 system (2013)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2013-07-31
    Description: Nature Methods 10, 741 (2013). doi:10.1038/nmeth.2532 Authors: Ari E Friedland, Yonatan B Tzur, Kevin M Esvelt, Monica P Colaiácovo, George M Church & John A Calarco We report the use of clustered, regularly interspaced, short palindromic repeats (CRISPR)-associated endonuclease Cas9 to target genomic sequences in the Caenorhabditis elegans germ line using single-guide RNAs that are expressed from a U6 small nuclear RNA promoter. Our results demonstrate that targeted, heritable genetic alterations can be achieved in C. elegans, providing a convenient and effective approach for generating loss-of-function mutants.
    Print ISSN: 1548-7091
    Electronic ISSN: 1548-7105
    Topics: Biology , Medicine
    Published by Nature Publishing Group (NPG)
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  • 4
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    Postglacial sediment budget of Chilliwack Valley, British Columbia (2012)
    Wiley-Blackwell
    Details
    Publication Date: 2012-02-21
    Description: The paraglacial reworking of glacial sediments by rivers and mass wasting is an important conditioning factor for modern sediment yields in mountainous catchments in formerly glaciated regions. Catchment scale and patterns of sediment storage are important influences in the rate of postglacial adjustment. We develop a quantitative framework to estimate the volume, sediment type, and fractional size distribution of legacy glacial materials in a large (1 230 km 2 ) watershed in the North Cascade Mountains in southwestern British Columbia, Canada. Chilliwack Valley is exceptional because of the well-dated bounds of deglaciation. Interpolation of paleo-surfaces from partially eroded deposits in the valley allows us to estimate the total evacuated sediment volume. We present a chronology of sediment evacuation from the valley and deposition in the outlet fan, based on infrared stimulated luminescence (IRSL) and 14  C dating of river terraces and fan strata, respectively. The effects of paraglacial sedimentation in Chilliwack Valley were intensified through a major fall in valley base-level following ice retreat. The steepened mainstem valley gradient led to deep incision of valley fills and fan deposits in the lower valley network. The results of this integrated study provide a postglacial chronology and detailed sediment budget, accounting for long term sorting of the original sediments, lag deposit formation in the mainstem, deposition in the outlet fan, and approximate downstream losses of suspended sediment and wash load. The mass balance indicates that a bulk volume of approximately 3.2 km 3 of glacial material has been evacuated from the valley. Copyright © 2012 John Wiley & Sons, Ltd.
    Print ISSN: 0197-9337
    Electronic ISSN: 1096-9837
    Topics: Geography , Geosciences
    Published by Wiley-Blackwell
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  • 5
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    U.S. Department of Agriculture Agricultural Research Service Mahantango Creek Watershed, Pennsylvania, United States: Long-term precipitation database (2011)
    Wiley-Blackwell
    Details
    Publication Date: 2011-08-20
    Description: A long-term precipitation database has been developed by the U.S. Department of Agriculture (USDA) Agricultural Research Service (ARS) Pasture Systems and Watershed Management Research Unit to support intensive hydrologic and water quality research within WE-38, a 7.3 km2 experimental subwatershed of Mahantango Creek Watershed located in east central Pennsylvania and draining to the Susquehanna River. Daily precipitation data were collected at three sites, with record lengths of 40 years (1968–2007) at two sites and of 29 years (1979–2007) at a third site. Data are available on the USDA ARS's Sustaining the Earth's Watersheds—Agricultural Research Data System (STEWARDS) Web site.
    Print ISSN: 0043-1397
    Electronic ISSN: 1944-7973
    Topics: Architecture, Civil Engineering, Surveying , Geography
    Published by Wiley-Blackwell on behalf of American Geophysical Union (AGU).
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  • 6
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    Postglacial sediment budget of Chilliwack Valley, British Columbia (2012)
    Wiley-Blackwell
    Details
    Publication Date: 2012-04-15
    Description: ABSTRACT The paraglacial reworking of glacial sediments by rivers and mass wasting is an important conditioning factor for modern sediment yields in mountainous catchments in formerly glaciated regions. Catchment scale and patterns of sediment storage are important influences in the rate of postglacial adjustment. We develop a quantitative framework to estimate the volume, sediment type, and fractional size distribution of legacy glacial materials in a large (1230 km 2 ) watershed in the North Cascade Mountains in south-western British Columbia, Canada. Chilliwack Valley is exceptional because of the well-dated bounds of deglaciation. Interpolation of paleo-surfaces from partially eroded deposits in the valley allows us to estimate the total evacuated sediment volume. We present a chronology of sediment evacuation from the valley and deposition in the outlet fan, based on infrared stimulated luminescence (IRSL) and 14  C dating of river terraces and fan strata, respectively. The effects of paraglacial sedimentation in Chilliwack Valley were intensified through a major fall in valley base-level following ice retreat. The steepened mainstem valley gradient led to deep incision of valley fills and fan deposits in the lower valley network. The results of this integrated study provide a postglacial chronology and detailed sediment budget, accounting for long-term sorting of the original sediments, lag deposit formation in the mainstem, deposition in the outlet fan, and approximate downstream losses of suspended sediment and wash load. The mass balance indicates that a bulk volume of approximately 3.2 km 3 of glacial material has been evacuated from the valley. Copyright © 2012 John Wiley & Sons, Ltd.
    Print ISSN: 0197-9337
    Electronic ISSN: 1096-9837
    Topics: Geography , Geosciences
    Published by Wiley-Blackwell
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  • 7
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    Ecogenomic sensor reveals controls on N2-fixing microorganisms in the North Pacific Ocean (2014)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2014-05-21
    Description: Ecogenomic sensor reveals controls on N2-fixing microorganisms in the North Pacific Ocean The ISME Journal 8, 1175 (June 2014). doi:10.1038/ismej.2013.244 Authors: Julie C Robidart, Matthew J Church, John P Ryan, François Ascani, Samuel T Wilson, Deniz Bombar, Roman Marin, Kelvin J Richards, David M Karl, Christopher A Scholin & Jonathan P Zehr
    Keywords: autonomous sensingbiosensorsdiazotrophsmicrobial oceanographynitrogen fixationtime-series
    Print ISSN: 1751-7362
    Electronic ISSN: 1751-7370
    Topics: Biology
    Published by Nature Publishing Group (NPG) on behalf of The International Society for Microbial Ecology (ISME).
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