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  • 1
    Online Resource
    Online Resource
    SAGE Publications ; 2018
    In:  Energy Exploration & Exploitation Vol. 36, No. 3 ( 2018-05), p. 373-387
    In: Energy Exploration & Exploitation, SAGE Publications, Vol. 36, No. 3 ( 2018-05), p. 373-387
    Abstract: The Ordovician dolomite reservoir in Ma5 5 –Ma5 10 sub-members in Jingxi in Ordos Basin is a newly discovered field with multiple natural gas pools. The gas accumulation patterns of the reservoir are unclear. Considering the geological background, the genesis, migration, and accumulation of natural gas in Jingxi were studied systematically, and favorable exploration targets were predicted. Natural gas in Ma5 5 –Ma5 10 sub-members is a mixture of Upper Paleozoic and Ordovician products. The Upper Paleozoic coaliferous gas was mainly expulsed downward through the hydrocarbon-providing window where the coal-bearing source rocks made contact with the dolomite reservoirs. The gas then migrated from west to east and accumulated under the condition of lithology variation. The Ordovician petroliferous gas mainly migrated from bottom to top through fractures and mixed with the coaliferous gas in Ma5 5 –Ma5 10 sub-members. The natural gas reservoir formation model was summarized as the migration of gas over a short distance and partial charging into the dolomite reservoirs from the Late Triassic to Middle Jurassic, and the migration of gas over a long distance and massive charging into the dolomite reservoirs during the Late Cretaceous. Ma5 5 and Ma5 6 sub-members are the focus of further exploration, and petroliferous gas in Ma5 7 –Ma5 10 sub-members deserves attention. The dolomite reservoirs of the hydrocarbon-providing windows and the east of these locations are the favorable exploration targets.
    Type of Medium: Online Resource
    ISSN: 0144-5987 , 2048-4054
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2018
    detail.hit.zdb_id: 2026571-2
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  • 2
    In: Natural Gas Industry B, Elsevier BV, Vol. 3, No. 3 ( 2016-05), p. 216-225
    Type of Medium: Online Resource
    ISSN: 2352-8540
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2016
    detail.hit.zdb_id: 2835766-8
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  • 3
    In: Acta Geologica Sinica - English Edition, Wiley, Vol. 91, No. 4 ( 2017-08), p. 1363-1379
    Abstract: We clarified three stages of dolomitization and secondary changes by studying the petrology and geochemistry characteristics of dolomite from the Ma5 5 –Ma5 10 sub‐members of the Ordovician Majiagou Formation in the Jingxi area in the Ordos Basin: (1) Syngenetic microbial dolomitization is characterized by formation of dolomite with a mainly micrite structure and horse tooth‐shape dolomite cements. (2) Seepage reflux dolomitization during the penecontemporaneous period superposed adjustment functions such as recrystallization and stabilization in the middle‐deep burial stage, forming dolomites mainly consisting of micro crystal and powder crystal structure. (3) Powder dolomite, fine dolomite, and medium‐coarse crystalline dolomite formed in pores and fractures in the middle‐deep burial stage. The secondary concussive transgression‐regression under a regressive background is an important condition for the occurrence of many stages of dolomitization in the study area. The basin was an occlusive epicontinental sea environment in the Ma5 member of the Ordovician Majiagou Formation sedimentary period. In the sediments, sulfate content was high, which is conducive to the preservation of microbial activity and microbial dolomitization. Micritic dolomite formed by microbial dolomitization provides good migration pathways for seepage reflux dolomitization. Affected by evaporation seawater with increased Mg/Ca ratio, seepage reflux dolomitization was widely developed and formed large‐scale dolomite, and underwater uplifts and slopes are favorable areas for dolomite. In the middle‐deep burial stage, dolomitizing fluid in the stratum recrystallized or stabilized the previous dolomite and formed a small amount of euhedral dolomite in the pores and fractures.
    Type of Medium: Online Resource
    ISSN: 1000-9515 , 1755-6724
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2017
    detail.hit.zdb_id: 2420386-5
    SSG: 6,25
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  • 4
    Online Resource
    Online Resource
    Institute of Electrical and Electronics Engineers (IEEE) ; 2017
    In:  IEEE Transactions on Microwave Theory and Techniques Vol. 65, No. 8 ( 2017-8), p. 2734-2748
    In: IEEE Transactions on Microwave Theory and Techniques, Institute of Electrical and Electronics Engineers (IEEE), Vol. 65, No. 8 ( 2017-8), p. 2734-2748
    Type of Medium: Online Resource
    ISSN: 0018-9480 , 1557-9670
    Language: Unknown
    Publisher: Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017
    detail.hit.zdb_id: 2028238-2
    detail.hit.zdb_id: 218509-X
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  • 5
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2015
    In:  Scientific Reports Vol. 5, No. 1 ( 2015-08-10)
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 5, No. 1 ( 2015-08-10)
    Abstract: The heritability of schizophrenia (SCZ) has been estimated to be as high as 80%, suggesting that genetic factors may play an important role in the etiology of SCZ. Cav1.2 encoded by CACNA1C and Cav1.3 encoded by CACNA1D are dominant calcium channel-forming subunits of L-type Voltage-dependent Ca 2+ channels, expressed in many types of neurons. The CACNA1C has been consistently found to be a risk gene for SCZ, but it is unknown for CACNA1D . To investigate the association of CACNA1D with SCZ, we designed a two-stage case-control study, including a testing set with 1117 cases and 1815 controls and a validation set with 1430 cases and 4295 controls in Han Chinese. A total of selected 97 tag single nucleotide polymorphisms (SNPs) in CACNA1D were genotyped and single-SNP association, imputation analysis and gender-specific association analyses were performed in the two independent datasets. None was found to associate with SCZ. Further genotype and haplotype association analyses indicated a similar pattern in the two-stage study. Our findings suggested CACNA1D might not be a risk gene for SCZ in Han Chinese population, which add to the current state of knowledge regarding the susceptibility of CACNA1D to SCZ.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2015
    detail.hit.zdb_id: 2615211-3
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  • 6
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 6, No. 1 ( 2016-04-22)
    Abstract: Voltage-gated L-type calcium channels (VLCC) are distributed widely throughout the brain. Among the genes involved in schizophrenia (SCZ), genes encoding VLCC subunits have attracted widespread attention. Among the four subunits comprising the VLCC (α − 1, α −2/δ, β and γ), the γ subunit that comprises an eight-member protein family is the least well understood. In our study, to further investigate the risk susceptibility by the γ subunit gene family to SCZ, we conducted a large-scale association study in Han Chinese individuals. The SNP rs17645023 located in the intergenic region of CACNG4 and CACNG5 was identified to be significantly associated with SCZ (OR = 0.856, P  = 5.43 × 10 −5 ). Similar results were obtained in the meta-analysis with the current SCZ PGC data (OR = 0.8853). We also identified a two-SNP haplotype (rs10420331-rs11084307, P = 1.4 × 10 −6 ) covering the intronic region of CACNG8 to be significantly associated with SCZ. Epistasis analyses were conducted and significant statistical interaction (OR = 0.622, P  = 2.93 × 10 −6 , P perm   〈  0.001) was observed between rs192808 ( CACNG6 ) and rs2048137 ( CACNG5 ). Our results indicate that CACNG4 , CACNG5 , CACNG6 and CACNG8 may contribute to the risk of SCZ. The statistical epistasis identified between CACNG5 and CACNG6 suggests that there may be an underlying biological interaction between the two genes.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2016
    detail.hit.zdb_id: 2615211-3
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  • 7
    Online Resource
    Online Resource
    Springer Science and Business Media LLC ; 2016
    In:  Scientific Reports Vol. 6, No. 1 ( 2016-11-29)
    In: Scientific Reports, Springer Science and Business Media LLC, Vol. 6, No. 1 ( 2016-11-29)
    Abstract: The 5-HT1A receptor (HTR1A) and the 5-HT5A receptor (HTR5A) are key 5-HT receptors with distinct inhibitory functions. Studies have been conducted to investigate the association of a few HTR1A polymorphisms with schizophrenia, producing conflicting results, and the relationship between HTR5A and schizophrenia has not yet been well investigated. We aimed to examine the association of HTR1A and HTR5A with schizophrenia and executive function. The study included a discovery stage with 1,115 patients and 2,289 controls and a replication stage with 2,128 patients and 3,865 controls. A total of 30 common SNPs in HTR1A and HTR5A were genotyped in the discovery stage, and significantly associated SNPs were genotyped in the replication stage. We identified that two SNPs (rs878567 in HTR1A and rs1800883 in HTR5A ) were significantly associated with schizophrenia in both datasets, and similar results were observed in imputation and haplotype association analyses. Moreover, we found that SNP rs1800883 significantly interacted with executive function when processing the perseverative error of Wisconsin Card Sorting Test in patients. Our results provide further supportive evidence of the effect of HTR1A and HTR5A on the etiology of schizophrenia and suggest that the selected genetic variations in HTR5A may be involved in impaired executive function.
    Type of Medium: Online Resource
    ISSN: 2045-2322
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2016
    detail.hit.zdb_id: 2615211-3
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  • 8
    Online Resource
    Online Resource
    S. Karger AG ; 2016
    In:  Pharmacology Vol. 97, No. 1-2 ( 2016), p. 31-37
    In: Pharmacology, S. Karger AG, Vol. 97, No. 1-2 ( 2016), p. 31-37
    Abstract: 〈 b 〉 〈 i 〉 Background: 〈 /i 〉 〈 /b 〉 In light of the growing number of cancer survivors, the incidence of cardiovascular complications in these patients had also increased, while the effect of apatinib on the pharmacokinetic of cardioprotective drug (carvedilol) in rats or human is still unknown. The present work was to study the impact of apatinib on the metabolism of carvedilol both in vitro and vivo. 〈 b 〉 〈 i 〉 Methods: 〈 /i 〉 〈 /b 〉 A specific and sensitive ultra-performance liquid-chromatography tandem mass spectrometry method was applied to determine the concentration of carvedilol and its metabolites (4′-hydroxyphenyl carvedilol [4′-HPC], 5′-hydroxyphenyl carvedilol [5′-HPC] and o-desmethyl carvedilol [o-DMC]). 〈 b 〉 〈 i 〉 Results: 〈 /i 〉 〈 /b 〉 The inhibition ratios in human liver microsomes were 10.28, 10.89 and 5.94% for 4′-HPC, 5′-HPC and o-DMC, respectively, while in rat liver microsomes, they were 3.22, 1.58 and 1.81%, respectively. The data in vitro of rat microsomes were consistent with the data in vivo that the inhibition of 4′-HPC and 5′-HPC formation was higher than the control group. 〈 b 〉 〈 i 〉 Conclusion: 〈 /i 〉 〈 /b 〉 Our study showed that apatinib could significantly inhibit the formation of carvedilol metabolites both in human and rat liver microsomes. It is recommended that the effect of apatinib on the metabolism of carvedilol should be noted and carvedilol plasma concentration should be monitored.
    Type of Medium: Online Resource
    ISSN: 0031-7012 , 1423-0313
    Language: English
    Publisher: S. Karger AG
    Publication Date: 2016
    detail.hit.zdb_id: 1483550-2
    SSG: 15,3
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  • 9
    Online Resource
    Online Resource
    SAGE Publications ; 2019
    In:  Energy Exploration & Exploitation Vol. 37, No. 1 ( 2019-01), p. 473-492
    In: Energy Exploration & Exploitation, SAGE Publications, Vol. 37, No. 1 ( 2019-01), p. 473-492
    Abstract: The Middle Ordovician Majiagou Formation in the eastern Ordos Basin, central China, is an important area in the exploration for tight carbonate gas, especially within weathering crust layers in the first and second submembers of the fifth member of the formation (herein referred to as Ma 5 1 + 2 ). However, karstification prevents a clear understanding of the petrological characteristics and facies distribution of these layers, which hinders exploration. Based on cores, thin sections, and cathodoluminescence analysis, we investigate the petrological characteristics of Ma 5 1 + 2 , determine the nature of lateral lithological variations in the eastern and central parts of the Ordos Basin, and constrain facies distribution in the region. In addition to karst breccias with unrecognizable parent rocks, Ma 5 1 + 2 comprises four lithologies: gypsum/halite mold-bearing micritic dolomite, micritic dolomite, grain dolomite, and microbial dolomite. We recognize three main sedimentary subfacies: restricted lagoon, grain shoal, and mound–shoal complex. Ma 5 1 + 2 records a complete transgression–regression cycle. The Ma 5 2 2 layer was deposited during a transgression associated with enhanced water circulation and abundant mound–shoal complexes, for which their frequency is positively correlated with the thickness of the unit. The Ma 5 1 2 layer and overlying deposits correspond to a regression cycle, and the abundance of mound–shoal complexes in these units is negatively correlated with layer thickness. The Ma 5 1 3 period represents the timing of maximum regression, when a gypsum-bearing dolomitic lagoon was dominant, associated with a restricted water body. The overall facies distribution is one of a restricted evaporite lagoon environment, similar to the central basin. Therefore, reservoir tightness is unlikely to be related to the sedimentary facies. The next phase of exploration should focus on “sweet spots” resulting from differential diagenesis or hydrocarbon accumulation. Our results provide guidance for research on tight carbonate reservoirs and hydrocarbon accumulation in other regions that experienced similar geological conditions.
    Type of Medium: Online Resource
    ISSN: 0144-5987 , 2048-4054
    Language: English
    Publisher: SAGE Publications
    Publication Date: 2019
    detail.hit.zdb_id: 2026571-2
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  • 10
    Online Resource
    Online Resource
    Elsevier BV ; 2015
    In:  Natural Gas Industry B Vol. 2, No. 4 ( 2015-10), p. 295-306
    In: Natural Gas Industry B, Elsevier BV, Vol. 2, No. 4 ( 2015-10), p. 295-306
    Type of Medium: Online Resource
    ISSN: 2352-8540
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2015
    detail.hit.zdb_id: 2835766-8
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