In:
International Journal of Cancer, Wiley, Vol. 145, No. 5 ( 2019-09), p. 1280-1289
Abstract:
What's new? Penile cancer is rare, and its genetic and molecular characteristics remain poorly understood. Here, the authors report a somatic mutation profile of penile cancer in Chinese men. First, they sequenced 30 paired blood and tumor samples and identified 11 frequently mutated genes. Some of these had been associated with penile cancer before, including NOTCH1 and TP53 . Others were newly identified by this work, including CASP8 . In penile cancer cells, disabling CASP8 prevented the induction of apoptosis, they showed. The most commonly disrupted pathways, occurring in more than 50% of the samples, were the Notch, RTK‐RAS, and Hippo pathways.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
Permalink