In:
Molecular Oncology, Wiley, Vol. 12, No. 6 ( 2018-06), p. 775-787
Abstract:
Glioblastoma ( GBM ) is the most common and deadly malignant brain cancer of glial cell origin, with a median patient survival of less than 20 months. Transcription factors FOXG 1 and TLE 1 promote GBM propagation by supporting maintenance of brain tumour‐initiating cells (BTICs) with stem‐like properties. Here, we characterize FOXG 1 and TLE 1 target genes in GBM patient‐derived BTICs using Ch IP ‐Seq and RNA ‐Seq approaches. These studies identify 150 direct FOXG 1 targets, several of which are also TLE 1 targets, involved in cell proliferation, differentiation, survival, chemotaxis and angiogenesis. Negative regulators of NOTCH signalling, including CHAC 1 , are among the transcriptional repression targets of FOXG 1: TLE 1 complexes, suggesting a crosstalk between FOXG 1: TLE 1 and NOTCH ‐mediated pathways in GBM . These results provide previously unavailable insight into the transcriptional programs underlying the tumour‐promoting functions of FOXG 1: TLE 1 in GBM .
Type of Medium:
Online Resource
ISSN:
1574-7891
,
1878-0261
DOI:
10.1002/mol2.2018.12.issue-6
DOI:
10.1002/1878-0261.12168
Language:
English
Publisher:
Wiley
Publication Date:
2018
detail.hit.zdb_id:
2322586-5
Permalink