In:
Journal of Magnetic Resonance Imaging, Wiley, Vol. 42, No. 6 ( 2015-12), p. 1723-1732
Abstract:
To evaluate the correlation between maximum standardized uptake value (SUV max ) and minimum apparent diffusion coefficient (ADC min ) of endometrial cancer derived from an integrated positron emission tomography / magnetic resonance (PET/MR) system and to determine their correlation with pathological prognostic factors. Materials and Methods This prospective study was approved by the Institutional Review Board of the hospital, and informed consent was obtained. Between April and December 2014, 47 consecutive patients with endometrial cancer were enrolled and underwent simultaneous PET/MR examinations before surgery. Thirty‐six patients with measurable tumors on PET/MR were included for image analysis. Pearson's correlation coefficient was used to evaluate the correlation between SUV max and ADC min of the tumors. The Mann–Whitney U ‐test was utilized to evaluate relationships between these two imaging biomarkers and pathological prognostic factors. Results The mean SUV max and ADC min were 14.7 ± 7.1 and 0.48 ± 0.13 × 10 −3 mm 2 /s, respectively. A significant inverse correlation was found between SUV max and ADC min ( r = –0.53; P = 0.001). SUV max was significantly higher in tumors with advanced stage, deep myometrial invasion, cervical invasion, lymphovascular space involvement, and lymph node metastasis ( P 〈 0.05). ADC min was lower in tumors with higher grade, advanced stage, and cervical invasion ( P 〈 0.05). The ratio of SUV max to ADC min was higher in tumors with higher grade, advanced stage, deep myometrial invasion, cervical invasion, lymphovascular space involvement, and lymph node metastasis ( P 〈 0.05). Conclusion SUV max and ADC min of endometrial cancer derived from integrated PET/MR are inversely correlated and are associated with pathological prognostic factors. J. MAGN. RESON. IMAGING 2015;42:1723–1732.
Type of Medium:
Online Resource
ISSN:
1053-1807
,
1522-2586
Language:
English
Publisher:
Wiley
Publication Date:
2015
detail.hit.zdb_id:
1497154-9
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