In:
Canadian Respiratory Journal, Hindawi Limited, Vol. 2016 ( 2016), p. 1-6
Abstract:
Background . Six-minute walk test (6MWT) has 3 measurement outcomes, which are walk distance, desaturation, and symptom. The aim of this study was to examine whether routinely measured right-heart catheter (RHC) data correlate with 6MWT outcomes in patients with interstitial lung disease (ILD). Methods . Between June 2010 and December 2012, consecutive patients with ILD who underwent evaluation, including pulmonary function test, hemodynamic studies with right-heart catheter, and 6MWT as routine general practice, were recruited. Correlates of 3 outcomes of 6MWT were examined to reveal significant predictors. Results . Forty-six patients consisting of 20 with idiopathic pulmonary fibrosis, 14 with collagen vascular disease associated ILD, and 12 with other idiopathic interstitial pneumonia were recruited (mean % predicted FVC: 76.7 ± 17 . 1 %). Several physiological variables, including mean pulmonary artery pressure (PAP) and pulmonary vascular resistance (PVR), were correlated with each 6MWT outcome. Stepwise multivariate regression analyses showed that % predicted FVC and % predicted DLco were independent predictors of walk distance ( r 2 = 0.3 5 , p = 0.0002 ). For SpO 2 at the end of 6MWT, % predicted DLco and PVR were selected as independent predictors ( r 2 = 0 . 46 , p 〈 0.000 1 ). For dyspnea at the end of 6MWT, % predicted DLco was only one predictor ( r 2 = 0.1 8 , p = 0.00 5 ). Conclusion . Mean PAP had little impact on 6MWT outcomes in ILD patients who were nonselectively recruited, although PVR was one of predictors of desaturation.
Type of Medium:
Online Resource
ISSN:
1198-2241
,
1916-7245
DOI:
10.1155/2016/3837182
Language:
English
Publisher:
Hindawi Limited
Publication Date:
2016
detail.hit.zdb_id:
2207107-6
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