In:
Clinical Transplantation, Wiley, Vol. 33, No. 12 ( 2019-12)
Abstract:
Bloodstream infection (BSI) is a life‐threatening complication after living donor liver transplantation (LDLT). We aimed to explore the incidence and predisposing factors of BSI at our institution. Methods We conducted a retrospective cohort analysis on all consecutive adults with BSI within 6 months after LDLT performed between 2005 and 2016. For antimicrobial prophylaxis, ampicillin/sulbactam, cefotaxime, and micafungin were administered. From 2011, methicillin‐resistant Staphylococcus aureus (MRSA) carriers were decolonized using mupirocin ointment and chlorhexidine gluconate soap. Risk factors for BSI were identified by uni‐ and multivariate logistic regression. Results Of a total of 106 LDLTs, 42 recipients (40%) suffered BSI. The BSI group demonstrated significantly higher in‐hospital mortality rates compared with the non‐BSI group (24% vs. 7%, P = .01). We identified MRSA carrier (odds ratio [OR], 19.1; P 〈 .001), ABO incompatibility (OR, 2.9; P = .03), and estimated glomerular filtration rate 〈 30 mL/min/1.73m 2 (OR, 15.8; P = .02) as independent risk factors for BSI. Decolonization treatment for MRSA carriers did not reduce the incidence of all‐cause BSI but reduced the frequency of BSI caused by MRSA. Conclusion To our knowledge, for the first time, MRSA carriers were revealed to be highly vulnerable to BSI after LDLT.
Type of Medium:
Online Resource
ISSN:
0902-0063
,
1399-0012
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
2739458-X
detail.hit.zdb_id:
2004801-4
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