In:
Asian Journal of Organic Chemistry, Wiley, Vol. 8, No. 3 ( 2019-03), p. 344-347
Abstract:
An approach to trifluoroacetylation of aromatic conjugated esters successfully led to the efficient and selective introduction of trifluoroacetyl group to the electron‐deficient β‐ or δ‐carbon atom of ester under mild reaction conditions by magnesium‐promoted reduction, followed by deacetalization with trifluoroacetic acid in moderate to good yields. A variety of fluorinated keto esters derived from ethyl cinnamates and β, γ‐ or γ‐, δ‐unsaturated fluorinated keto esters from aromatic dienoesters with a longer conjugation system were synthesized through this simple methodology utilizing ethyl trifluoroacetate as a fluorine‐containing carbon source.
Type of Medium:
Online Resource
ISSN:
2193-5807
,
2193-5815
DOI:
10.1002/ajoc.201800741
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
2679333-7
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