In:
Annals of Surgery, Ovid Technologies (Wolters Kluwer Health), Vol. 267, No. 6 ( 2018-06), p. 1126-1133
Abstract:
To investigate the influence of donor age on recipient outcome after living-donor partial liver transplantation (LDLT). Background: Donor age is a well-known prognostic factor in deceased donor liver transplantation; however, its role in LDLT remains unclear. Methods: We retrospectively analyzed 315 consecutive cases of primary adult-to-adult LDLT in our center between April 2006 and March 2014. Recipients were divided into 5 groups according to the donor age: D-20s ( n = 60); D-30s ( n = 72); D-40s ( n = 57); D-50s ( n = 94); and D-60s ( n = 32). The recipient survival and the association with various clinical factors were investigated. Results: Recipient survival proportions were significantly higher in D-20s compared with all the other groups ( P = 0.008, 〈 0.001, 〈 0.001, and = 0.006, vs D-30s, -40s, -50s, and -60s, respectively), whereas there was no association between recipient survival and their own age. There are 3 typical relationships between donors and recipients in adult-to-adult LDLT: from child-to-parent , between spouses/siblings , and from parent-to-child . The overall survival in child-to-parent was significantly higher than in spouses/siblings ( P = 0.002) and in parent-to-child ( P = 0.005), despite significantly higher recipient age in child-to-parent [59 (42–69) years, P 〈 0.001]. Contrastingly, parent-to-child exhibited the lowest survival, despite the youngest recipient age [26 (20–43) years, P 〈 0.001]. In addition, younger donor age exhibited significantly better recipient survival both in hepatitis C virus-related and in non-hepatitis C virus diseases. Univariate and multivariate analyses both demonstrated that donor age and graft-type (right-sided livers) are independent prognostic factors for recipient survival. Conclusions: Donor age is an independent, strong prognostic factor in adult-to-adult LDLT.
Type of Medium:
Online Resource
ISSN:
0003-4932
,
1528-1140
DOI:
10.1097/SLA.0000000000002194
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2018
detail.hit.zdb_id:
2641023-0
detail.hit.zdb_id:
2002200-1
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