In:
Cancer Research, American Association for Cancer Research (AACR), Vol. 75, No. 9_Supplement ( 2015-05-01), p. P1-02-11-P1-02-11
Abstract:
Background: The aim of this study was to evaluate the significance of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) for predicting the underestimation of invasive breast cancer in cases of ductal carcinoma in situ (DCIS) at needle biopsy. Patients and Methods: Of 83 consecutive cases with diagnoses of DCIS at primary needle biopsy who underwent curative surgery between 2010 and 2013, the association between the maximum standardized uptake value (SUVmax) on FDG-PET/CT before excision and the underestimation of invasive breast cancer was examined. Results: There were 29 (34.9%) cases diagnosed to have invasive breast cancer at excision. Receiver operating characteristics (ROC) curve analysis showed the cutoff value of SUVmax to predict underestimation of invasive breast cancer was 1.6. The rates of underestimation were 61.5% for patients with a tumor of SUVmax & gt; 1.6 and 11.4% for patients with a tumor SUV max ≤ 1.6 (p & lt;0.001). High value of SUVmax was significantly associated with symptomatic presentation (p & lt; 0.001), palpability (p & lt; 0.001), mass formation (p = 0.013), high Breast Imaging Reporting and Data System category (p = 0.011) and core needle biopsy (p = 0.007). In multivariate analysis, high SUVmax was only significant predictive factor of underestimation of invasive breast cancer (HR 11.7, 95% CI 3.70-37.0, p & lt; 0.001). Association between each preoperative variable and underestimation of invasive component in multivariate analysis in cases of DCIS diagnosed at needle biopsyVariables HR (95% CI)P valuePresentationsymptomatic vs. screening detected1.64 (0.43-6.22)0.47Palpableyes vs. no1.54 (0.36-6.69)0.58Lesion size & lt; 2cm vs. ≥ 2cm1.23 (0.34-4.40)0.76Mass formationyes vs. no1.28 (0.36-4.44)0.7BI RADS category5 vs. 3, 42.92 (0.80-10.7)0.11Biopsy devicemammotome biopsy vs. CNB2.16 (0..64-7.30)0.21Nuclear gradehigh vs. not highhigh vs. not high 2.24 (0.51-9.78)0.29SUVmaxhigher vs. lower11.7 (3.70-37.0) & lt; 0.001BI RADS, Breast Imaging Reporting and Data System; DCIS, ductal carcinoma in situ; IBC, invasive breast cancer; SUVmax, maximum standardized uptake value Conclusion: SUVmax on FDG-PET/CT is useful for predicting the underestimation of invasive breast cancer in cases of DCIS at needle biopsy. Citation Format: Hideo Shigematsu, Takayuki Kadoya, Noriko Yoshimura, Keiko Kajitani, Akiko Emi, Noriko Masumoto, Rumi Haruta, Tsuyoshi Kataoka, Morihito Okada. Role of FDG-PET/CT in prediction of underestimation of invasive breast cancer in cases of ductal carcinoma in situ diagnosed at needle biopsy [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AAC R San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P1-02-11.
Type of Medium:
Online Resource
ISSN:
0008-5472
,
1538-7445
DOI:
10.1158/1538-7445.SABCS14-P1-02-11
Language:
English
Publisher:
American Association for Cancer Research (AACR)
Publication Date:
2015
detail.hit.zdb_id:
2036785-5
detail.hit.zdb_id:
1432-1
detail.hit.zdb_id:
410466-3
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