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  • 1
    Online Resource
    Online Resource
    Sa1184 Endoscopist and Center ERCP Volume Are Associated With Increased Success Rates: A Systematic Review and Meta-Analysis
    Elsevier BV ; 2016
    In:  Gastrointestinal Endoscopy Vol. 83, No. 5 ( 2016-05), p. AB246-AB247
    Details
    In: Gastrointestinal Endoscopy, Elsevier BV, Vol. 83, No. 5 ( 2016-05), p. AB246-AB247
    Type of Medium: Online Resource
    ISSN: 0016-5107
    URL: Article
    DOI: 10.1016/j.gie.2016.03.348
    RVK:
    XA 44545
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2016
    detail.hit.zdb_id: 2006253-9
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  • 2
    Online Resource
    Online Resource
    Effect of rituximab on a salivary gland ultrasound score in primary Sjögren’s syndrome: results of the TRACTISS randomised double-blind multicentre substudy
    BMJ ; 2018
    In:  Annals of the Rheumatic Diseases Vol. 77, No. 3 ( 2018-03), p. 412-416
    Details
    In: Annals of the Rheumatic Diseases, BMJ, Vol. 77, No. 3 ( 2018-03), p. 412-416
    Abstract: To compare the effects of rituximab versus placebo on salivary gland ultrasound (SGUS) in primary Sjögren’s syndrome (PSS) in a multicentre, multiobserver phase III trial substudy. Methods Subjects consenting to SGUS were randomised to rituximab or placebo given at weeks 0, 2, 24 and 26, and scanned at baseline and weeks 16 and 48. Sonographers completed a 0–11 total ultrasound score (TUS) comprising domains of echogenicity, homogeneity, glandular definition, glands involved and hypoechoic foci size. Baseline-adjusted TUS values were analysed over time, modelling change from baseline at each time point. For each TUS domain, we fitted a repeated-measures logistic regression model to model the odds of a response in the rituximab arm (≥1-point improvement) as a function of the baseline score, age category, disease duration and time point. Results 52 patients (n=26 rituximab and n=26 placebo) from nine centres completed baseline and one or more follow-up visits. Estimated between-group differences (rituximab-placebo) in baseline-adjusted TUS were −1.2 (95% CI −2.1 to −0.3; P=0.0099) and −1.2 (95% CI −2.0 to −0.5; P=0.0023) at weeks 16 and 48. Glandular definition improved in the rituximab arm with an OR of 6.8 (95% CI 1.1 to 43.0; P=0.043) at week 16 and 10.3 (95% CI 1.0 to 105.9; P=0.050) at week 48. Conclusions We demonstrated statistically significant improvement in TUS after rituximab compared with placebo. This encourages further research into both B cell depletion therapies in PSS and SGUS as an imaging biomarker. Trial registration number 65360827, 2010-021430-64; Results.
    Type of Medium: Online Resource
    ISSN: 0003-4967 , 1468-2060
    URL: Article
    URL: Article
    DOI: 10.1136/annrheumdis-2017-212268
    DOI: 10.1136/annrheumdis-2017-212268.supp1
    RVK:
    XA 10000
    Language: English
    Publisher: BMJ
    Publication Date: 2018
    detail.hit.zdb_id: 1481557-6
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  • 3
    Online Resource
    Online Resource
    Economic burden of food allergy
    Elsevier BV ; 2019
    In:  Annals of Allergy, Asthma & Immunology Vol. 122, No. 4 ( 2019-04), p. 373-380.e1
    Details
    In: Annals of Allergy, Asthma & Immunology, Elsevier BV, Vol. 122, No. 4 ( 2019-04), p. 373-380.e1
    Type of Medium: Online Resource
    ISSN: 1081-1206
    URL: Article
    DOI: 10.1016/j.anai.2019.01.014
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2019
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  • 4
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    Positive affect and medication adherence in chronic conditions: A systematic review.
    American Psychological Association (APA) ; 2019
    In:  Health Psychology Vol. 38, No. 11 ( 2019-11), p. 960-974
    Details
    In: Health Psychology, American Psychological Association (APA), Vol. 38, No. 11 ( 2019-11), p. 960-974
    Type of Medium: Online Resource
    ISSN: 1930-7810 , 0278-6133
    URL: Article
    DOI: 10.1037/hea0000778
    RVK:
    CL 1000
    Language: English
    Publisher: American Psychological Association (APA)
    Publication Date: 2019
    detail.hit.zdb_id: 2101103-5
    SSG: 5,2
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  • 5
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    The efficacy of smoking cessation interventions in low‐ and middle‐income countries: a systematic review and meta‐analysis
    Wiley ; 2019
    In:  Addiction Vol. 114, No. 4 ( 2019-04), p. 620-635
    Details
    In: Addiction, Wiley, Vol. 114, No. 4 ( 2019-04), p. 620-635
    Abstract: To summarize evidence for the efficacy of smoking cessation interventions in low‐ and middle‐income countries (LMICs). Design Systematic review and meta‐analysis of randomized controlled trials. Setting LMICs as defined by the World Bank. Participants Adult current cigarette smokers residing in LMICs. Interventions Behavioral and/or pharmacotherapy smoking cessation interventions. Measurements PubMed MEDLINE, EMBASE (embase.com), Cochrane Central Register of Controlled Trials (Wiley), PsycINFO (Ebsco), SciELO, WHO Global Index Medicus and Scopus were searched from inception to 4 April 2018. Only studies with at least 6 months of follow‐up were included. We used the most rigorous assessment of abstinence reported by each study. Effect sizes were computed from abstracted data. Where possible, a meta‐analysis was performed using Mantel–Haenzel random‐effect models reporting odds ratios (OR) and 95% confidence intervals (CI). Findings Twenty‐four randomized controlled trials were included. Six investigated the efficacy of pharmacological agents. Four trials that compared nicotine replacement therapy (NRT) to placebo found NRT improved cessation rates ( n  : NRT 546, control 684, OR = 1.76, 95% CI = 1.30–2.77, P   〈  0.001, I 2  = 13%). Eight trials found that behavioral counseling was more effective than minimal interventions (e.g. brief advice); n  : Counseling 2941, control 2794, OR = 6.87, 95% CI = 4.18–11.29, P   〈  0.001, I 2  = 67%). There was also evidence of the benefit of brief advice over usual care ( n  : Brief advice 373, control 355, OR = 2.46, 95% CI = 1.56–3.88, P   〈  0.001, I 2  = 0%). Conclusion Nicotine replacement therapy, behavioral counseling and brief advice appear to be effective in aiding smoking cessation in low‐ and middle‐income countries. There is limited rigorous research on other smoking cessation interventions in these regions.
    Type of Medium: Online Resource
    ISSN: 0965-2140 , 1360-0443
    URL: Issue
    URL: Article
    DOI: 10.1111/add.v114.4
    DOI: 10.1111/add.14518
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2002997-4
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  • 6
    Online Resource
    Online Resource
    Interventions for Frequently Hospitalized Patients and Their Effect on Outcomes: A Systematic Review
    Wiley ; 2018
    In:  Journal of Hospital Medicine Vol. 13, No. 12 ( 2018-12), p. 853-859
    Details
    In: Journal of Hospital Medicine, Wiley, Vol. 13, No. 12 ( 2018-12), p. 853-859
    Abstract: A small subset of patients account for a substantial proportion of hospital readmissions. Programs to reduce utilization among this subset of frequently hospitalized patients have the potential to improve health and reduce unnecessary spending. PURPOSE To conduct a systematic review of interventions targeting frequently hospitalized patients. DATA SOURCES PubMed MEDLINE; Embase (embase. com); and Cochrane Central Register of Controlled Trials, January 1, 1980 to January 1, 2018. STUDY SELECTION Four physicians screened 4762 titles and abstracts for inclusion. Authors reviewed 116 full‐text studies and included 9 meeting criteria. DATA EXTRACTION Study characteristics, outcomes, and details regarding interventions were extracted. Risk of bias was assessed by the Downs and Black Scale. DATA SYNTHESIS Out of the nine included studies, three were randomized controlled trials, three were controlled retrospective cohort studies, and three were uncontrolled pre‐post studies. Inclusion criteria, interventions used, and outcomes assessed varied across studies. While all nine studies demonstrated reduced utilization, studies with lower risk of bias generally found similar reductions in utilization between intervention and control groups. Interventions commonly consisted of interdisciplinary teams interacting with patients across health care settings. CONCLUSIONS Interventions targeting high need, high‐cost patients are heterogeneous, with many studies observing a regression to the mean. More rigorous studies, using multifaceted interventions which can adapt to patients' unique needs should be conducted to assess the effect on outcomes relevant to both providers and patients.
    Type of Medium: Online Resource
    ISSN: 1553-5592 , 1553-5606
    URL: Article
    DOI: 10.12788/jhm.3090
    Language: English
    Publisher: Wiley
    Publication Date: 2018
    detail.hit.zdb_id: 2221544-X
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  • 7
    Online Resource
    Online Resource
    A systematic review of patient perspectives on surveillance after colorectal cancer treatment
    Springer Science and Business Media LLC ; 2017
    In:  Journal of Cancer Survivorship Vol. 11, No. 5 ( 2017-10), p. 542-552
    Details
    In: Journal of Cancer Survivorship, Springer Science and Business Media LLC, Vol. 11, No. 5 ( 2017-10), p. 542-552
    Type of Medium: Online Resource
    ISSN: 1932-2259 , 1932-2267
    URL: Article
    DOI: 10.1007/s11764-017-0623-2
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2017
    detail.hit.zdb_id: 2388888-X
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  • 8
    Online Resource
    Online Resource
    Intrauterine Device Insertion Failure After Misoprostol Administration : A Systematic Review
    Ovid Technologies (Wolters Kluwer Health) ; 2016
    In:  Obstetrics & Gynecology Vol. 128, No. 5 ( 2016-11), p. 1084-1091
    Details
    In: Obstetrics & Gynecology, Ovid Technologies (Wolters Kluwer Health), Vol. 128, No. 5 ( 2016-11), p. 1084-1091
    Abstract: To examine rates of intrauterine device (IUD) insertion failure with and without prior misoprostol administration. Additional outcomes included difficulty of insertion, subjective pain, expulsion, and complications. DATA SOURCES: Systematic searches were performed in PubMed MEDLINE, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, and Cumulative Index to Nursing and Allied Health Literature for articles with the following keywords: “misoprostol,” “intrauterine devices,” and “IUDs.” METHODS OF STUDY SELECTION: A total of 161 unique results were retrieved. Titles, abstracts, and full-text articles were independently screened twice by two reviewers for content and relevance. Quality assessment was performed using previously established criteria. After screening and quality assessment, nine randomized controlled trials (RCTs) were obtained for inclusion. Six articles were designated high quality and three were designated low quality. TABULATION, INTEGRATION, AND RESULTS: Six of six RCTs examining IUD insertion failure with misoprostol revealed no difference in this measure. Of nine RCTs examining difficulty of IUD insertion with misoprostol, seven revealed no difference in this measure and two revealed decreased difficulty of insertion with misoprostol administration. Of nine RCTs examining pain with IUD insertion, seven revealed no difference in pain measurement scores, one revealed increased pain with misoprostol administration, and one revealed decreased pain with misoprostol administration. Five studies examining rates of expulsion and two studies examining complications of IUD insertion revealed no difference in this measure. CONCLUSION: No data support routine administration of misoprostol before IUD insertion. Success of insertion is high even among nulliparous women, and good-quality data do not demonstrate that misoprostol use increases success. These data similarly reveal no differences in difficulty of insertion, pain with insertion, or expulsion with prior administration of misoprostol. However, data for several outcomes are limited by lack of power.
    Type of Medium: Online Resource
    ISSN: 0029-7844
    URL: Article
    DOI: 10.1097/AOG.0000000000001696
    Language: English
    Publisher: Ovid Technologies (Wolters Kluwer Health)
    Publication Date: 2016
    detail.hit.zdb_id: 2012791-1
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  • 9
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    Online Resource
    Epithelial to mesenchymal plasticity and differential response to therapies in pancreatic ductal adenocarcinoma
    Proceedings of the National Academy of Sciences ; 2019
    In:  Proceedings of the National Academy of Sciences Vol. 116, No. 52 ( 2019-12-26), p. 26835-26845
    Details
    In: Proceedings of the National Academy of Sciences, Proceedings of the National Academy of Sciences, Vol. 116, No. 52 ( 2019-12-26), p. 26835-26845
    Abstract: Transcriptional profiling has defined pancreatic ductal adenocarcinoma (PDAC) into distinct subtypes with the majority being classical epithelial (E) or quasi-mesenchymal (QM). Despite clear differences in clinical behavior, growing evidence indicates these subtypes exist on a continuum with features of both subtypes present and suggestive of interconverting cell states. Here, we investigated the impact of different therapies being evaluated in PDAC on the phenotypic spectrum of the E/QM state. We demonstrate using RNA-sequencing and RNA-in situ hybridization (RNA-ISH) that FOLFIRINOX combination chemotherapy induces a common shift of both E and QM PDAC toward a more QM state in cell lines and patient tumors. In contrast, Vitamin D, another drug under clinical investigation in PDAC, induces distinct transcriptional responses in each PDAC subtype, with augmentation of the baseline E and QM state. Importantly, this translates to functional changes that increase metastatic propensity in QM PDAC, but decrease dissemination in E PDAC in vivo models. These data exemplify the importance of both the initial E/QM subtype and the plasticity of E/QM states in PDAC in influencing response to therapy, which highlights their relevance in guiding clinical trials.
    Type of Medium: Online Resource
    ISSN: 0027-8424 , 1091-6490
    URL: Article
    DOI: 10.1073/pnas.1914915116
    RVK:
    TA 1000
    RVK:
    WA 15000
    Language: English
    Publisher: Proceedings of the National Academy of Sciences
    Publication Date: 2019
    detail.hit.zdb_id: 209104-5
    detail.hit.zdb_id: 1461794-8
    SSG: 11
    SSG: 12
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  • 10
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    Online Resource
    Design and development of the molecular analysis for Therapy Choice (NCI-MATCH) Designated Laboratory Network.
    American Society of Clinical Oncology (ASCO) ; 2019
    In:  Journal of Clinical Oncology Vol. 37, No. 15_suppl ( 2019-05-20), p. 3016-3016
    Details
    In: Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 37, No. 15_suppl ( 2019-05-20), p. 3016-3016
    Abstract: 3016 Background: NCI-MATCH is a precision medicine trial that assigns treatment to refractory cancer patients by tumor mutation profile rather than by histology. After screening fresh tumor biopsies from nearly 6000 patients many treatment arms did not meet accrual due to the low prevalence of the eligible variants. NCI MATCH developed an approach to identify patients for the remaining arms utilizing a network of academic and commercial CLIA-certified labs that perform NGS assays as routine care at MATCH participating sites. Methods: Candidate labs were recruited through a notice in the Federal Register and posted on the NCI and ECOG ACRIN web sites. Twenty-seven labs (17 academic/10 commercial) submitted applications. After acceptance each lab analyzed a common set of 10 DNAs extracted from 8 cell lines and 2 clinical samples for concordance with the central NCI-MATCH NGS assay. Results: For the 17 labs with concordance results, a median of 8 (range 2 – 58) copy number variants (CNVs) were evaluated by the NGS assay of each DL, with the number evaluated depending on each lab’s clinical assay panel content. CNV concordance between central and DL assays, as measured by positive percent agreement (PPA), averaged 98.7% (range 87.5% - 100%) with the central assay as referent and 94.1% (range 77.8% – 100%) with the DL assay as referent. For single nucleotide variants (SNVs) and Insertion/deletions (Indels) combined, a median of 19 variants (range 11 – 26) were evaluated by each DL for concordance. PPA between central and DL assays averaged 98.0% (range 87.5% – 100%) and 98.6% (range 90.0% – 100%) with central and DL assay as referents, respectively. Strong correlations were observed between central and DL assays for both CNVs (median r = 0.93; 0.33 – 1.00) and SNV/Indels (median r = 0.98; 0.67 – 0.99). Conclusions: Our results suggest that different NGS assay platforms using diverse strategies for target enrichment and data analysis may still achieve high concordance if pre-analytical variables are minimized and the common genomic regions interrogated by each assay are well-understood. The designated lab network allows for a wider search for rare variants in tumors and provides a model for conducting future clinical trials. Clinical trial information: NCT02465060.
    Type of Medium: Online Resource
    ISSN: 0732-183X , 1527-7755
    URL: Article
    DOI: 10.1200/JCO.2019.37.15_suppl.3016
    RVK:
    XA 52760
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Clinical Oncology (ASCO)
    Publication Date: 2019
    detail.hit.zdb_id: 2005181-5
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