In:
International Journal of Cancer, Wiley, Vol. 145, No. 1 ( 2019-07), p. 164-178
Abstract:
What's new? While solid tumors are known to enter periods of clinical dormancy, how cancer cells reside in this quiescent (G 0 ) state and what circumstances cause them to re‐enter the cell cycle to facilitate cancer recurrence and progression remain unanswered. Here, G 0 transition to a proliferative state in prostate and lung cancer cells was found to be dependent on the histone chaperone complex facilitates chromatin transcription (FACT). Experiments showed that FACT levels are reduced in G 0 cancer cells and restored upon cell cycle re‐entry. Re‐entry was impeded by FACT silencing, which blocked p27 degradation, an event normally observed when cells resume proliferation.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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