In:
Proceedings of the Royal Society B: Biological Sciences, The Royal Society, Vol. 283, No. 1823 ( 2016-01-27), p. 20152691-
Abstract:
Meiotic recombination is believed to produce greater genetic variation despite the fact that deoxyribonucleic acid (DNA)-replication errors are a major source of mutations. In some vertebrates, mutation rates are higher in males than in females, which developed the theory of male-driven evolution (male-biased mutation). However, there is little molecular evidence regarding the relationships between meiotic recombination and male-biased mutation. Here we tested the theory using the frog Rana rugosa, which has both XX/XY- and ZZ/ZW-type sex-determining systems within the species. The male-to-female mutation-rate ratio ( α ) was calculated from homologous sequences on the X/Y or Z/W sex chromosomes, which supported male-driven evolution. Surprisingly, each α value was notably higher in the XX/XY-type group than in the ZZ/ZW-type group, although α should have similar values within a species. Interestingly, meiotic recombination between homologous chromosomes did not occur except at terminal regions in males of this species. Then, by subdividing α into two new factors, a replication-based male-to-female mutation-rate ratio ( β ) and a meiotic recombination-based XX-to-XY/ZZ-to-ZW mutation-rate ratio ( γ ), we constructed a formula describing the relationship among a nucleotide-substitution rate and the two factors, β and γ . Intriguingly, the β - and γ -values were larger and smaller than 1, respectively, indicating that meiotic recombination might reduce male-biased mutations.
Type of Medium:
Online Resource
ISSN:
0962-8452
,
1471-2954
DOI:
10.1098/rspb.2015.2691
Language:
English
Publisher:
The Royal Society
Publication Date:
2016
detail.hit.zdb_id:
1460975-7
SSG:
12
SSG:
25
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