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  • 1
    In: Advanced Science, Wiley, Vol. 6, No. 14 ( 2019-07)
    Abstract: Perturbation of potassium homeostasis can affect various cell functions and lead to the onset of programmed cell death. Although ionophores have been intensively used as an ion homeostasis disturber, the mechanisms of cell death are unclear and the bioapplicability is limited. In this study, helical polypeptide‐based potassium ionophores are developed to induce endoplasmic reticulum (ER) stress‐mediated apoptosis. The polypeptide‐based potassium ionophores disturb ion homeostasis and then induce prolonged ER stress in the cells. The ER stress results in oxidative environments that accelerate the activation of mitochondria‐dependent apoptosis. Moreover, ER stress‐mediated apoptosis is triggered in a tumor‐bearing mouse model that suppresses tumor proliferation. This study provides the first evidence showing that helical polypeptide‐based potassium ionophores trigger ER stress‐mediated apoptosis by perturbation of potassium homeostasis.
    Type of Medium: Online Resource
    ISSN: 2198-3844 , 2198-3844
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2808093-2
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  • 2
    In: Advanced Science, Wiley, Vol. 6, No. 14 ( 2019-07)
    Type of Medium: Online Resource
    ISSN: 2198-3844 , 2198-3844
    URL: Issue
    Language: English
    Publisher: Wiley
    Publication Date: 2019
    detail.hit.zdb_id: 2808093-2
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  • 3
    Online Resource
    Online Resource
    American Diabetes Association ; 2019
    In:  Diabetes Vol. 68, No. Supplement_1 ( 2019-06-01)
    In: Diabetes, American Diabetes Association, Vol. 68, No. Supplement_1 ( 2019-06-01)
    Abstract: Background: Although the association between low-normal thyroid function and metabolic syndrome was well documented, little is known about the effect of thyroid hormone within the physiological range on carbohydrate metabolism. This study aimed to determine whether free thyroxine (FT4) influences serum glucose concentration and the prevalence of prediabetes in euthyroid subjects. Methods: This was a cross-sectional survey derived from the Korea National Health and Nutrition Examination Survey, conducted between 2013 and 2015. We studied 4,767 participants of & gt;20 years of age who were euthyroid and nondiabetic. Results: Prediabetic participants had lower FT4 concentrations than those without prediabetes, but thyrotropin concentrations were similar. We stratified the population into tertiles according to FT4 concentration. After adjusting for multiple confounding factors, HbA1c levels significantly decreased with FT4 tertile, whereas FBG was not associated with FT4 both in men and in women. The prevalence of prediabetes was significantly higher in T1 than in T3. Conclusion: Subjects with low-normal serum FT4 had high HbA1c and were more likely to have the prediabetes. These results suggest that low FT4 concentration is a risk factor for prediabetes, even though thyroid function is within the normal range. Thus, screening for prediabetes in subjects with low-normal FT4 should involve the measurement of HbA1c. Disclosure S. Kim: None. E. Jeon: None. J. Lee: None. H. Shon: None. K. Park: None.
    Type of Medium: Online Resource
    ISSN: 0012-1797 , 1939-327X
    Language: English
    Publisher: American Diabetes Association
    Publication Date: 2019
    detail.hit.zdb_id: 1501252-9
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  • 4
    Online Resource
    Online Resource
    American Diabetes Association ; 2018
    In:  Diabetes Vol. 67, No. Supplement_1 ( 2018-07-01)
    In: Diabetes, American Diabetes Association, Vol. 67, No. Supplement_1 ( 2018-07-01)
    Abstract: Objective: The effect of past use of oral contraceptives (OCs) at child-bearing on the incidence of diabetes and insulin resistance (IR) after menopause is not clearly elucidated. This study aimed to evaluate the association of past use of OCs with the development of diabetes and IR in post-menopausal women. Methods: This cross-sectional study was based on data from the Korea National Health and Nutrition Examination Survey from 2007 to 2012. Of the 50,4participants, 6554 post-menopausal women were selected and included in the analysis. The long-term effects of OCs use on the prevalence of diabetes in post-menopausal women were examined using multivariate logistic analysis. In addition, fasting glucose and insulin levels were measured in 3338 nondiabetic post-menopausal women, and the association between IR and OCs was examined by analysis of covariance. Results: The prevalence of diabetes was significantly higher in post-menopausal participants who had taken OCs for more than 6 months than in those who had never taken OCs. The association remained significant after adjusting for multiple confounding factors (odd ratio, 1.379; 95% CI, 1.115-1.707; P=0.003). The duration of OCs use was also positively associated with the prevalence of diabetes. Furthermore, taking OCs for more than 6 months led to a significant increase in fasting insulin levels and HOMA-IR in nondiabetic participants. Conclusion: Past use of OCs for more than 6 months led to a significant increase in the prevalence of diabetes in post-menopausal women, and increased IR in nondiabetes participants. These results suggested that prolonged use of OCs at a reproductive age is an important risk factor for developing diabetes in post-menopausal women. Disclosure S. Kim: None. R. Kim: None. E. Jeon: None. J. Lee: None. H. Shon: None.
    Type of Medium: Online Resource
    ISSN: 0012-1797 , 1939-327X
    Language: English
    Publisher: American Diabetes Association
    Publication Date: 2018
    detail.hit.zdb_id: 1501252-9
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  • 5
    Online Resource
    Online Resource
    Cognizant, LLC ; 2019
    In:  Acupuncture & Electro-Therapeutics Research Vol. 44, No. 1 ( 2019-03-01), p. 23-38
    In: Acupuncture & Electro-Therapeutics Research, Cognizant, LLC, Vol. 44, No. 1 ( 2019-03-01), p. 23-38
    Abstract: Objectives: Papillary thyroid cancer (PTe) is the most common type of thyroid cancer and the most common endocrine malignancy. Although it has a good prognosis, patients experience weight gain, fatigue, and neck pain after total thyroidectomy, and quality of life (QOL) can also decline. There is no effective treatment for these symptoms. This study evaluated the feasibility and safety of acupuncture for treating of fatigue in patients with PTC after total thyroidectomy. Methods: This is a prospective randomized controlled study using before and after measurements. The subjects included 25 patients with thyroid cancer who had undergone total thyroidectomy and were experiencing fatigue. Twelve patients underwent Saam (or Sa-Ahm) acupuncture treatment and thirteen subjects did not. Saam acupuncture, which is one of the original therapeutic modalities representing traditional Korean medicine, is a unique treatment method that has a different origin than the modalities from China and Japan. The basic characteristic of combining five shu points in Saam acupuncture is the selection of the tonification and sedation points along the self-meridian and other meridians based on creation and governor relationships. Acupuncture treatment was delivered two times a week for 6 weeks, in 25 to 30 minutes at each session. Acupoints were individually tailored according to the individual pattern of each patient. Fatigue severity and QOL were evaluated using the fatigue scale score and Short Form-36 (SF-36), respectively. Fatigue severity scale is a 9-item self-report questionnaire scale developed by Krupp et al. in 1989. SF-36 is a 36-item, patient-reported survey of patient health. Body weight, body mass index, fatigue scale score, and SF-36 score were evaluated pre- and post-treatment, and laboratory tests for biochemical variables were also performed. Results: Fatigue scale score (FSS) significantly improved in the acupuncture group (FSS; 29.92 to 19.50, decrease; 91.7%) compared to the control group (FSS; 29.92 to 31.15, decrease; 46.2%) at post-treatment compared to baseline (p=O. Oll). SF-36 scores were 74.12 in the acupuncture group and 69.02 in the control group, with no statistically significant difference (p=0.085). Weight change did not differ between the two groups. Liver enzymes such as aspartate aminotransferase were lower in the acupuncture group (27.67 to 24.33 IUIL) than in the control group (20.77 to 24.08 IUIL) (p=O. Ol). No other biochemical markers differed between the two groups. Conclusions: Acupuncture such as ST-36, CV-4, KI-10, and HT-8 may relieve fatigue and improve QOL in patients PTC who experience fatigue, and reduced QOL after total thyroidectomy without biochemical changes. A larger prospective study is required to confirm these effects.
    Type of Medium: Online Resource
    ISSN: 0360-1293
    Language: English
    Publisher: Cognizant, LLC
    Publication Date: 2019
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  • 6
    Online Resource
    Online Resource
    Bioscientifica ; 2016
    In:  Endocrine Abstracts ( 2016-05-13)
    In: Endocrine Abstracts, Bioscientifica, ( 2016-05-13)
    Type of Medium: Online Resource
    ISSN: 1479-6848
    Language: Unknown
    Publisher: Bioscientifica
    Publication Date: 2016
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  • 7
    Online Resource
    Online Resource
    American Diabetes Association ; 2019
    In:  Diabetes Vol. 68, No. Supplement_1 ( 2019-06-01)
    In: Diabetes, American Diabetes Association, Vol. 68, No. Supplement_1 ( 2019-06-01)
    Abstract: Objective: Currently, emotional well-being is becoming an increasingly important aspect of diabetes care and self-management. Routine screening for depressive symptoms is indicated in high-risk populations, including people with prediabetes and diabetes. However, a limited number of studies about the relationship between prediabetes and depression have been conducted in Asians. The aim of this study was to investigate the potential synergistic relationship between prediabetes and depression. Methods: This was a cross-sectional survey derived from the 2014 Korea National Health and Nutrition Examination Survey. 9-item Patient Health Questionnaire (PHQ-9) depression-screening test was used. Depression was defined as a score ≥10 on PHQ-9. Prediabetes was defined by the presence of impaired fasting glucose or A1c between 5.7 and 6.4%. Results: In total, 3848 subjects (1570 Men and 2278 women) aged 16 to 80 years without diabetes were studies. Among them, 1809 (47%) were prediabetes. The prevalence of depression was higher in the participants with prediabetes (4.7%) than without prediabetes (3.4%) (P & lt;0.003). On multivariate logistic analyse, depression was significantly related with prediabetic participant with obesity (odds ratio (OR)= 3.103; 95% confidence interval (CI), 1.295-7.439). However, depression was not related with prediabeteic participant wit underweight (OR =1.001; CI, 0.662-1.514). Conclusion: This study shows the risk of depression in prediabetes with obesity. Future research is required to examine the mechanisms underlying the associations between prediabetes, mental health, and the risk of diabetes. Disclosure E. Jeon: None. S. Kim: None. J. Lee: None. H. Shon: None.
    Type of Medium: Online Resource
    ISSN: 0012-1797 , 1939-327X
    Language: English
    Publisher: American Diabetes Association
    Publication Date: 2019
    detail.hit.zdb_id: 1501252-9
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