In:
Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 137, No. suppl_1 ( 2018-03-20)
Abstract:
Background: The demographic, behavioral or lifestyle factors associated with transitioning from metabolically healthy (MHO) to metabolically unhealthy obesity (MUO) are unknown. Methods: CARDIA participants (n=735) were included if they were not obese (BMI 〈 30 kg/m 2 ) at baseline and developed obesity at exams 7, 10, 15, 20, or 25 years. MHO was defined as the presence of obesity and 0-1 risk factor: SBP/DBP ≥130/85mmHg; glucose ≥100mg/dL; triglycerides (≥150mg/dL); and HDL-C (men 〈 40, women 〈 50mg/dL) or on relevant medication. MUO was defined as obesity and 2+ risk factors. Duration of MHO and obesity were estimated (yrs). Phenotypes were categorized by MHO duration (%; MHO duration÷obesity duration): stable MHO (100%); transient MHO (1-99%); MUO (0%). Factors were compared between phenotypes using linear or logistic regression (adjusted for sex, race, baseline BMI, age). Multinomial logistic regression analysis was used to determine which factors [obesity duration, BMI change (ΔBMI), obesity onset age, physical activity (PA), alcohol intake, smoking] associated with transient MHO and MUO, relative to stable MHO. Results: Participants were 55% black and 72% women. Relative to transient MHO (n=184, 25%), stable MHO (n=347, 47%) had 5.4±0.5 yrs later obesity onset, 3.4±0.4 kg/m 2 smaller ΔBMI, 5.6±0.5 yrs shorter obesity duration, and 2.4±0.5 yrs longer MHO duration (all p 〈 0.0001), with no significant differences for PA (moderate, vigorous or total), alcohol or smoking. Relative to stable MHO, transient MHO were less likely to be female, but more likely to smoke, have increased obesity duration and ΔBMI. Relative to stable MHO, MUO (n=204, 28%) were less likely to be female or black, more likely to smoke, have lower total PA, lower alcohol, and increased ΔBMI (Table 1). Conclusion: Obesity duration, ΔBMI and smoking were the strongest correlates of transition from MHO to MUO. MUO were more likely to have adverse health factors. Additional research should explore the cardiovascular consequences of the transition of MHO to MUO.
Type of Medium:
Online Resource
ISSN:
0009-7322
,
1524-4539
DOI:
10.1161/circ.137.suppl_1.mp29
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2018
detail.hit.zdb_id:
1466401-X
detail.hit.zdb_id:
80099-5
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