In:
Advanced Science, Wiley, Vol. 6, No. 5 ( 2019-03)
Abstract:
Thermally activated delayed fluorescence (TADF) materials have provided new strategies for time‐resolved luminescence imaging (TRLI); however, the development of hydrophilic TADF luminophores for specific imaging in cells remains a substantial challenge. In this study, a mitochondria‐induced aggregation strategy for TRLI is proposed with the design and utilization of the hydrophilic TADF luminophore ((10‐(1,3‐dioxo‐2‐phenyl‐2,3‐dihydro‐1H‐benzo[de]isoquinolin‐6‐yl)‐9,9‐dimethyl‐9,10‐dihydroacridin‐2‐yl)methyl)triphenylphosphonium bromide (NID‐TPP) . Using a nonconjugated linker to introduce a triphenylphosphonium (TPP + ) group into the 6‐(9,9‐dimethylacridin‐10(9 H )‐yl)‐2‐phenyl‐1H‐benzo[ de ]isoquinoline‐1,3(2 H )‐dione (NID) TADF luminophore preserves the TADF emission of NID‐TPP . NID‐TPP shows clear aggregation‐induced delayed fluorescence enhancement behavior, which provides a practical strategy for long‐lived delayed fluorescence emission in an oxygen‐containing environment. Finally, the designed mitochondrion‐targeting TPP + group in NID‐TPP induces the adequate accumulation of NID‐TPP and results in the first reported TADF‐based time‐resolved luminescence imaging and two‐photon imaging of mitochondria in living cells.
Type of Medium:
Online Resource
ISSN:
2198-3844
,
2198-3844
DOI:
10.1002/advs.201801729
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
2808093-2
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