In:
Angewandte Chemie, Wiley, Vol. 129, No. 24 ( 2017-06-06), p. 6912-6916
Abstract:
Inspired by the unique character of enzymes, we developed novel chiral SPO (secondary‐phosphine‐oxide) ligand (SPO‐Wudaphos) which can enter into both ion pair and H‐bond noncovalent interactions. The novel chiral SPO‐Wudaphos exhibited excellent results in the asymmetric hydrogenation of α‐methylene‐γ‐keto carboxylic acids, affording the chiral γ‐keto acids with up to over 99 % ee . A series of control experiments and DFT calculations were conducted to illustrate the critical roles of both the ion pair and H‐bond noncovalent interactions.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v129.24
DOI:
10.1002/ange.201701394
Language:
English
Publisher:
Wiley
Publication Date:
2017
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505872-7
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1479266-7
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