In:
International Journal of Cancer, Wiley, Vol. 144, No. 3 ( 2019-02), p. 533-544
Abstract:
What's new? Multiple single nucleotide polymorphisms (SNPs) have been associated with hepatocellular carcinoma (HCC) through genome‐wide association studies (GWAS). Few of these variants, however, have been cross‐validated, raising questions about their relation to HCC. Here, nine SNPs previously linked to HCC or liver damage were selected for investigation in European patients. Two of the variants, PNPLA3 rs738409 and TM6SF2 rs58542926, were found to be associated with HCC risk specifically in patients with alcoholic liver disease. PNPLA3 rs738409 was also associated with HCC in patients with nonfibrotic livers, where it potentially influences liver carcinogenesis via modification of protein function without altering gene expression.
Type of Medium:
Online Resource
ISSN:
0020-7136
,
1097-0215
Language:
English
Publisher:
Wiley
Publication Date:
2019
detail.hit.zdb_id:
218257-9
detail.hit.zdb_id:
1474822-8
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