In:
Angewandte Chemie, Wiley, Vol. 130, No. 42 ( 2018-10-15), p. 14093-14097
Abstract:
The first catalytic hydrocarboxylation of enamides and imines with CO 2 to generate valuable α,α‐disubstituted α‐amino acids is reported. Notably, excellent chemo‐ and regio‐selectivity are achieved, significantly different from previous reports on β‐carboxylation of enamides, homocoupling or reduction of imines. Moreover, this transition‐metal‐free procedure exhibits low loading of an inexpensive catalyst, easily available substrates, mild reaction conditions, high efficiency, facile scalability and easy product derivatization, providing great potential for application in organic synthesis, pharmaceutical chemistry, and biochemistry.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.v130.42
DOI:
10.1002/ange.201806874
Language:
English
Publisher:
Wiley
Publication Date:
2018
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514305-6
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505872-7
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1479266-7
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506259-7
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