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  • 1
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    University of Wyoming, Department of Renewable Resources | Laramie, Wyoming
    Publication Date: 2021-05-19
    Description: Institutional, environmental, and economic factors are affecting water quality and quantity within the River Njoro, a major tributary to Lake Nakuru. Between 1979 and 1999, the population within the Njoro watershed greatly increased, from 270,912 people to 413,698 spurring large-scale land use change and increased pressure on watershed resources. In 2003, the USAID funded, Sustainable Management of Rural Watersheds Project (SUMAWA) implemented participatory rural appraisals in the Njoro watershed to identify water use and other resource concerns within the area. Local residents identified two main concerns: 1) lower water quality and associated increases in water borne diseases and 2) reduced access to water and lack of improved water supplies related in part to reduced water quantity. Preliminary results suggest that the hydrologic response within the watershed has been altered to favor increased annual runoff with higher intensity and longer dry spells (Baldyga, 2005). Forest conversion to small-scale agriculture reduces canopy cover, thus exposing soils. If rainfall rates exceed infiltration rates, water once intercepted by the forest canopy contributes to flow flashiness and altered flow regimes. In turn, this may affect the recharge timing of Lake Nakuru.
    Description: Published
    Keywords: GIS ; Water quality ; Fishery institutions ; Water use ; Watersheds ; Lake basins ; Environmental impact
    Repository Name: AquaDocs
    Type: Report , Not Known
    Format: 9pp.
    Location Call Number Limitation Availability
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  • 2
    Publication Date: 2016-09-23
    Description: Background Over recent years genetic testing for germline mutations in BRCA1/BRCA2 has become more readily available because of technological advances and reducing costs. Objective To explore the feasibility and acceptability of offering genetic testing to all women recently diagnosed with epithelial ovarian cancer (EOC). Methods Between 1 July 2013 and 30 June 2015 women newly diagnosed with EOC were recruited through six sites in East Anglia, UK into the Genetic Testing in Epithelial Ovarian Cancer (GTEOC) study. Eligibility was irrespective of patient age and family history of cancer. The psychosocial arm of the study used self-report, psychometrically validated questionnaires (Depression Anxiety and Stress Scale (DASS-21); Impact of Event Scale (IES)) and cost analysis was performed. Results 232 women were recruited and 18 mutations were detected (12 in BRCA1 , 6 in BRCA2 ), giving a mutation yield of 8%, which increased to 12% in unselected women aged 〈70 years (17/146) but was only 1% in unselected women aged ≥70 years (1/86). IES and DASS-21 scores in response to genetic testing were significantly lower than equivalent scores in response to cancer diagnosis (p〈0.001). Correlation tests indicated that although older age is a protective factor against any traumatic impacts of genetic testing, no significant correlation exists between age and distress outcomes. Conclusions The mutation yield in unselected women diagnosed with EOC from a heterogeneous population with no founder mutations was 8% in all ages and 12% in women under 70. Unselected genetic testing in women with EOC was acceptable to patients and is potentially less resource-intensive than current standard practice.
    Keywords: Open access, Breast cancer
    Print ISSN: 0022-2593
    Electronic ISSN: 1468-6244
    Topics: Medicine
    Published by BMJ Publishing Group
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