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  • 1
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    University of Wyoming, Department of Renewable Resources | Laramie, Wyoming
    Publication Date: 2021-05-19
    Description: Institutional, environmental, and economic factors are affecting water quality and quantity within the River Njoro, a major tributary to Lake Nakuru. Between 1979 and 1999, the population within the Njoro watershed greatly increased, from 270,912 people to 413,698 spurring large-scale land use change and increased pressure on watershed resources. In 2003, the USAID funded, Sustainable Management of Rural Watersheds Project (SUMAWA) implemented participatory rural appraisals in the Njoro watershed to identify water use and other resource concerns within the area. Local residents identified two main concerns: 1) lower water quality and associated increases in water borne diseases and 2) reduced access to water and lack of improved water supplies related in part to reduced water quantity. Preliminary results suggest that the hydrologic response within the watershed has been altered to favor increased annual runoff with higher intensity and longer dry spells (Baldyga, 2005). Forest conversion to small-scale agriculture reduces canopy cover, thus exposing soils. If rainfall rates exceed infiltration rates, water once intercepted by the forest canopy contributes to flow flashiness and altered flow regimes. In turn, this may affect the recharge timing of Lake Nakuru.
    Description: Published
    Keywords: GIS ; Water quality ; Fishery institutions ; Water use ; Watersheds ; Lake basins ; Environmental impact
    Repository Name: AquaDocs
    Type: Report , Not Known
    Format: 9pp.
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  • 2
    Publication Date: 2015-07-10
    Description: Blockade of the programmed cell death 1 (PD-1)/programmed death-ligand 1 (PD-L1) immune checkpoint augments antitumor immunity and induces durable responses in patients with solid cancers, but data on clinical efficacy in leukemias are sparse. Chronic lymphocytic leukemia (CLL) is associated with a tumor-supportive microenvironment and a dysfunctional immune system, as shown by "exhausted" T cells, defective immunologic synapse formation, and immunosuppressive myeloid cells. These defects involve aberrant expression of PD-L1 and are closely mirrored in the Eµ-TCL1 mouse model for CLL. In this study, we treated mice after adoptive transfer of Eµ-TCL1 CLL with PD-L1–blocking antibodies, which prevented CLL development and was accompanied by a reactivation of immune effector functions. This included restoration of mature macrophages and major histocompatibility complex class II–expressing dendritic cells and prevention of aberrant and exhaustion-like T-cell phenotypes. In addition, PD-L1 blockade restored CD8 T-cell cytotoxicity and immune synapse formation and normalized T-cell cytokines and proliferation ex vivo and in vivo. Our data demonstrate that early PD-L1 blockade effectively corrects leukemia-induced immune dysfunction and thus prevents CLL development in mice. Targeting PD-L1/PD-1 interactions should therefore be further explored in clinical studies with CLL patients, ideally in combination with novel compounds to help eliminate CLL.
    Keywords: Immunobiology, Lymphoid Neoplasia
    Print ISSN: 0006-4971
    Electronic ISSN: 1528-0020
    Topics: Biology , Medicine
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