GLORIA

GEOMAR Library Ocean Research Information Access

X

Ihre E-Mail wurde erfolgreich gesendet. Bitte prüfen Sie Ihren Maileingang.

Leider ist ein Fehler beim E-Mail-Versand aufgetreten. Bitte versuchen Sie es erneut.

Vorgang fortführen?

Exportieren
Filter
  • Wiley  (28)
  • 2015-2019  (28)
  • 1
    Online-Ressource
    Online-Ressource
    Spectrum of combined respiratory chain defects
    Wiley ; 2015
    In:  Journal of Inherited Metabolic Disease Vol. 38, No. 4 ( 2015-07), p. 629-640
    Details
    In: Journal of Inherited Metabolic Disease, Wiley, Vol. 38, No. 4 ( 2015-07), p. 629-640
    Kurzfassung: Inherited disorders of mitochondrial energy metabolism form a large and heterogeneous group of metabolic diseases. More than 250 gene defects have been reported to date and this number continues to grow. Mitochondrial diseases can be grouped into (1) disorders of oxidative phosphorylation (OXPHOS) subunits and their assembly factors, (2) defects of mitochondrial DNA, RNA and protein synthesis, (3) defects in the substrate‐generating upstream reactions of OXPHOS, (4) defects in relevant cofactors and (5) defects in mitochondrial homeostasis. Deficiency of more than one respiratory chain enzyme is a common finding. Combined defects are found in 49 % of the known disease‐causing genes of mitochondrial energy metabolism and in 57 % of patients with OXPHOS defects identified in our diagnostic centre. Combined defects of complexes I, III, IV and V are typically due to deficiency of mitochondrial DNA replication, RNA metabolism or translation. Defects in cofactors can result in combined defects of various combinations, and defects of mitochondrial homeostasis can result in a generalised decrease of all OXPHOS enzymes. Noteworthy, identification of combined defects can be complicated by different degrees of severity of each affected enzyme. Furthermore, even defects of single respiratory chain enzymes can result in combined defects due to aberrant formation of respiratory chain supercomplexes. Combined OXPHOS defects have a great variety of clinical manifestations in terms of onset, course severity and tissue involvement. They can present as classical encephalomyopathy but also with hepatopathy, nephropathy, haematologic findings and Perrault syndrome in a subset of disorders.
    Materialart: Online-Ressource
    ISSN: 0141-8955 , 1573-2665
    URL: Article
    DOI: 10.1007/s10545-015-9831-y
    RVK:
    YC 6270
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2015
    ZDB Id: 2006875-X
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 2
    Online-Ressource
    Online-Ressource
    The spectrum of pyruvate oxidation defects in the diagnosis of mitochondrial disorders
    Wiley ; 2015
    In:  Journal of Inherited Metabolic Disease Vol. 38, No. 3 ( 2015-05), p. 391-403
    Details
    In: Journal of Inherited Metabolic Disease, Wiley, Vol. 38, No. 3 ( 2015-05), p. 391-403
    Kurzfassung: Pyruvate oxidation defects (PODs) are among the most frequent causes of deficiencies in the mitochondrial energy metabolism and represent a substantial subset of classical mitochondrial diseases. PODs are not only caused by deficiency of subunits of the pyruvate dehydrogenase complex (PDHC) but also by various disorders recently described in the whole pyruvate oxidation route including cofactors, regulation of PDHC and the mitochondrial pyruvate carrier. Our own patients from 2000 to July 2014 and patients identified by a systematic survey of the literature from 1970 to July 2014 with a pyruvate oxidation disorder and a genetically proven defect were included in the study (n=628). Of these defects 74.2% (n=466) belong to PDHC subunits, 24.5% (n=154) to cofactors, 0.5% (n=3) to PDHC regulation and 0.8% (n=5) to mitochondrial pyruvate import. PODs are underestimated in the field of mitochondrial diseases because not all diagnostic centres include biochemical investigations of PDHC in their routine analysis. Cofactor and transport defects can be missed, if pyruvate oxidation is not measured in intact mitochondria routinely. Furthermore deficiency of the X‐chromosomal PDHA1 can be biochemically missed depending on the X‐inactivation pattern. This is reflected by an increasing number of patients diagnosed recently by genetic high throughput screening approaches. PDHC deficiency including regulation and import affect mainly the glucose dependent central and peripheral nervous system and skeletal muscle. PODs with combined enzyme defects affect also other organs like heart, lung and liver. The spectrum of clinical presentation of PODs is still expanding. PODs are a therapeutically interesting group of mitochondrial diseases since some can be bypassed by ketogenic diet or treated by cofactor supplementation. PDHC kinase inhibition, chaperone therapy and PGC1α stimulation is still a matter of further investigations.
    Materialart: Online-Ressource
    ISSN: 0141-8955 , 1573-2665
    URL: Article
    DOI: 10.1007/s10545-014-9787-3
    RVK:
    YC 6270
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2015
    ZDB Id: 2006875-X
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 3
    Online-Ressource
    Online-Ressource
    Emotionally aligned: Preliminary results on the effects of a mindfulness‐based intervention for depression on congruence between implicit and explicit mood
    Wiley ; 2018
    In:  Clinical Psychology & Psychotherapy Vol. 25, No. 6 ( 2018-11), p. 818-826
    Details
    In: Clinical Psychology & Psychotherapy, Wiley, Vol. 25, No. 6 ( 2018-11), p. 818-826
    Kurzfassung: Mindfulness‐based interventions (MBIs) are effective in treating major depression. Because mindfulness involves monitoring and accepting current experiences, it may lead people resolve incongruencies between emotional responses that would otherwise remain unnoticed. Mindfulness may thus foster congruence between implicit and explicit emotions. The current randomized controlled trial tested this notion. Methods N  = 39 patients with an acute depressive episode were randomly assigned to an 8‐week MBI ( n  = 24) or a psychopharmacological consultation condition ( n  = 15). Explicit and implicit mood and depressive symptoms were assessed before treatment and at the end of treatment. Results Compared with the control condition, patients receiving MBI demonstrated higher congruence between implicit and explicit negative mood after treatment. There was no such difference in congruence of implicit and explicit positive mood. Additional analyses showed that only within the MBI group, individual differences in explicit mood became less stable. In contrast, individual differences in implicit mood remained stable in both groups. Limitations There was no control group including an active psychological intervention, the sample was small, and emotional congruence was not assessed within persons. Conclusions These findings correspond with the idea that mindfulness reduces incongruencies between implicit and explicit emotional responses. We found preliminary evidence for this effect for negative emotional responses. There was suggestive evidence that congruence arose from the alignment of explicit responses (which became less stable) to implicit responses (which remained stable). Studying the interplay between implicit and explicit processes may shed light on the working mechanisms of clinical‐psychological interventions.
    Materialart: Online-Ressource
    ISSN: 1063-3995 , 1099-0879
    URL: Issue
    URL: Article
    DOI: 10.1002/cpp.v25.6
    DOI: 10.1002/cpp.2317
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2018
    ZDB Id: 2004636-4
    SSG: 2,1
    SSG: 5,2
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 4
    Online-Ressource
    Online-Ressource
    Clinical significance of detectable and quantifiable HCV RNA at the end of treatment with ledipasvir/sofosbuvir in GT 1 patients
    Wiley ; 2018
    In:  Liver International Vol. 38, No. 11 ( 2018-11), p. 1906-1910
    Details
    In: Liver International, Wiley, Vol. 38, No. 11 ( 2018-11), p. 1906-1910
    Kurzfassung: AASLD / IDSA treatment guidelines for hepatitis C virus ( HCV ) infection state that testing for quantitative HCV RNA can be considered at the end of antiviral treatment ( EOT ) with interferon‐free regimens. However, it remains unclear how to respond to a detectable or even quantifiable HCV RNA result. The aim of this study was to analyse the frequency and predictive value of detectable and quantifiable HCV RNA results at the EOT in patients with HCV genotype 1 infection treated with ledipasvir ( LDV ) and sofosbuvir ( SOF ) ± ribavirin ( RBV ) in a large real‐world cohort. Methods A retrospective analysis of the DHC ‐R (Deutsches Hepatitis C‐Register, German Hepatitis C‐Registry) cohort was performed including all patients who were treated with LDV / SOF  ±  RBV and in whom HCV RNA testing was done with either the Roche COBAS AmpliPrep/ COBAS TaqMan ( CAP / CTM ) or the Abbott RealTime HCV assay ( ART ). Results The frequency of detectable HCV RNA at the EOT was 7% in this real‐world study involving 471 patients. Furthermore, 3% of the patients (n = 14/471) even had quantifiable viral load at the EOT . Detectable and quantifiable results were more frequent if the ART was used for testing. However, SVR was achieved by 32/33 patients (97%) with detectable and even by all 14 patients (100%) with quantifiable HCV RNA results at the EOT . Conclusion Detectable and even quantifiable HCV RNA results are quite frequent if highly sensitive HCV RNA assays are used. However, treatment prolongation is not indicated, as SVR rates remain high in these patients.
    Materialart: Online-Ressource
    ISSN: 1478-3223 , 1478-3231
    URL: Issue
    URL: Article
    DOI: 10.1111/liv.2018.38.issue-11
    DOI: 10.1111/liv.13932
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2018
    ZDB Id: 2124684-1
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 5
    Online-Ressource
    Online-Ressource
    A disulfide bridge in the calcium binding site of a polyester hydrolase increases its thermal stability and activity against polyethylene terephthalate
    Wiley ; 2016
    In:  FEBS Open Bio Vol. 6, No. 5 ( 2016-05), p. 425-432
    Details
    In: FEBS Open Bio, Wiley, Vol. 6, No. 5 ( 2016-05), p. 425-432
    Kurzfassung: Elevated reaction temperatures are crucial for the efficient enzymatic degradation of polyethylene terephthalate (PET). A disulfide bridge was introduced to the polyester hydrolase TfCut2 to substitute its calcium binding site. The melting point of the resulting variant increased to 94.7 °C (wild‐type TfCut2: 69.8 °C) and its half‐inactivation temperature to 84.6 °C (TfCut2: 67.3 °C). The variant D204C‐E253C‐D174R obtained by introducing further mutations at vicinal residues showed a temperature optimum between 75 and 80 °C compared to 65 and 70 °C of the wild‐type enzyme. The variant caused a weight loss of PET films of 25.0 ± 0.8% (TfCut2: 0.3 ± 0.1%) at 70 °C after a reaction time of 48 h. The results demonstrate that a highly efficient and calcium‐independent thermostable polyester hydrolase can be obtained by replacing its calcium binding site with a disulfide bridge.
    Materialart: Online-Ressource
    ISSN: 2211-5463 , 2211-5463
    URL: Article
    DOI: 10.1002/2211-5463.12053
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2016
    ZDB Id: 2651702-4
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 6
    Online-Ressource
    Online-Ressource
    Is It All about the Higher Dose? Why Psychoanalytic Therapy Is an Effective Treatment for Major Depression
    Wiley ; 2015
    In:  Clinical Psychology & Psychotherapy Vol. 22, No. 6 ( 2015-11), p. 469-487
    Details
    In: Clinical Psychology & Psychotherapy, Wiley, Vol. 22, No. 6 ( 2015-11), p. 469-487
    Kurzfassung: Empirical evidence for the effectiveness of long‐term psychodynamic psychotherapy (LTPP) in patients with mood disorders is growing. However, it is unclear whether the effectiveness of LTPP is due to distinctive features of psychodynamic/psychoanalytic techniques or to a higher number of sessions. We tested these rival hypotheses in a quasi‐experimental study comparing psychoanalytic therapy (i.e., high‐dose LTPP) with psychodynamic therapy (i.e., low‐dose LTPP) and cognitive–behavioural therapy (CBT) for depression. Analyses were based on a subsample of 77 subjects, with 27 receiving psychoanalytic therapy, 26 receiving psychodynamic therapy and 24 receiving CBT. Depressive symptoms, interpersonal problems and introject affiliation were assessed prior to treatment, after treatment and at the 1‐, 2‐ and 3‐year follow‐ups. Psychoanalytic techniques were assessed from three audiotaped middle sessions per treatment using the Psychotherapy Process Q‐Set. Subjects receiving psychoanalytic therapy reported having fewer interpersonal problems, treated themselves in a more affiliative way directly after treatment and tended to improve in depressive symptoms and interpersonal problems during follow‐up as compared with patients receiving psychodynamic therapy and/or CBT. Multilevel mediation analyses suggested that post‐treatment differences in interpersonal problems and introject affiliation were mediated by the higher number of sessions, and follow‐up differences in depressive symptoms were mediated by the more pronounced application of psychoanalytic techniques. We also found some evidence for indirect treatment effects via psychoanalytic techniques on changes in introject affiliation during follow‐up. These results provide support for the prediction that both a high dose and the application of psychoanalytic techniques facilitate therapeutic change in patients with major depression. Copyright © 2014 John Wiley & Sons, Ltd. Key Practitioner Message Psychoanalytic therapy is an effective treatment for major depression, especially in the long run. The differential effectiveness of psychoanalytic therapy cannot be fully explained by its higher dose. Distinctive features of psychoanalytic technique (e.g., focusing on patients' dreams, fantasies, sexual experiences or childhood memories) may play an important role in establishing sustained therapeutic change.
    Materialart: Online-Ressource
    ISSN: 1063-3995 , 1099-0879
    URL: Issue
    URL: Article
    DOI: 10.1002/cpp.v22.6
    DOI: 10.1002/cpp.1917
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2015
    ZDB Id: 2004636-4
    SSG: 2,1
    SSG: 5,2
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 7
    Online-Ressource
    Online-Ressource
    Engineered bacterial polyester hydrolases efficiently degrade polyethylene terephthalate due to relieved product inhibition
    Wiley ; 2016
    In:  Biotechnology and Bioengineering Vol. 113, No. 8 ( 2016-08), p. 1658-1665
    Details
    In: Biotechnology and Bioengineering, Wiley, Vol. 113, No. 8 ( 2016-08), p. 1658-1665
    Kurzfassung: Recent studies on the enzymatic degradation of synthetic polyesters have shown the potential of polyester hydrolases from thermophilic actinomycetes for modifying or degrading polyethylene terephthalate (PET). TfCut2 from Thermobifida fusca KW3 and LC‐cutinase (LCC) isolated from a compost metagenome are remarkably active polyester hydrolases with high sequence and structural similarity. Both enzymes exhibit an exposed active site in a substrate binding groove located at the protein surface. By exchanging selected amino acid residues of TfCut2 involved in substrate binding with those present in LCC, enzyme variants with increased PET hydrolytic activity at 65°C were obtained. The highest activity in hydrolyzing PET films and fibers were detected with the single variant G62A and the double variant G62A/I213S. Both variants caused a weight loss of PET films of more than 42% after 50 h of hydrolysis, corresponding to a 2.7‐fold increase compared to the wild type enzyme. Kinetic analysis based on the released PET hydrolysis products confirmed the superior hydrolytic activity of G62A with a fourfold higher hydrolysis rate constant and a 1.5‐fold lower substrate binding constant than those of the wild type enzyme. Mono‐(2‐hydroxyethyl) terephthalate is a strong inhibitor of TfCut2. A determination of the Rosetta binding energy suggested a reduced interaction of G62A with 2PET, a dimer of the PET monomer ethylene terephthalate. Indeed, G62A revealed a 5.5‐fold lower binding constant to the inhibitor than the wild type enzyme indicating that its increased PET hydrolysis activity is the result of a relieved product inhibition by mono‐(2‐hydroxyethyl) terephthalate. Biotechnol. Bioeng. 2016;113: 1658–1665. © 2016 Wiley Periodicals, Inc.
    Materialart: Online-Ressource
    ISSN: 0006-3592 , 1097-0290
    URL: Issue
    URL: Article
    DOI: 10.1002/bit.v113.8
    DOI: 10.1002/bit.25941
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2016
    ZDB Id: 1480809-2
    ZDB Id: 280318-5
    SSG: 12
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 8
    Online-Ressource
    Online-Ressource
    Quantitative T 1 and proton density mapping with direct calculation of radiofrequency coil transmit and receive profiles from two‐point variable flip angle data
    Wiley ; 2016
    In:  NMR in Biomedicine Vol. 29, No. 3 ( 2016-03), p. 349-360
    Details
    In: NMR in Biomedicine, Wiley, Vol. 29, No. 3 ( 2016-03), p. 349-360
    Kurzfassung: Quantitative T 1 mapping of brain tissue is frequently based on the variable flip angle (VFA) method, acquiring spoiled gradient echo (GE) datasets at different excitation angles. However, accurate T 1 calculation requires a knowledge of the sensitivity profile B 1 of the radiofrequency (RF) transmit coil. For an additional derivation of proton density (PD) maps, the receive coil sensitivity profile (RP) must also be known. Mapping of B 1 and RP increases the experiment duration, which may be critical when investigating patients. In this work, a method is presented for the direct calculation of B 1 and RP from VFA data. Thus, quantitative maps of T 1 , PD, B 1 and RP can be obtained from only two spoiled GE datasets. The method is based on: (1) the exploitation of the linear relationship between 1/PD and 1/ T 1 in brain tissue and (2) the assumption of smoothly varying B 1 and RP, so that a large number of data points can be fitted across small volume elements where B 1 and RP are approximately constant. The method is tested and optimized on healthy subjects. Copyright © 2016 John Wiley & Sons, Ltd.
    Materialart: Online-Ressource
    ISSN: 0952-3480 , 1099-1492
    URL: Issue
    URL: Article
    DOI: 10.1002/nbm.v29.3
    DOI: 10.1002/nbm.3460
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2016
    ZDB Id: 2002003-X
    ZDB Id: 1000976-0
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 9
    Online-Ressource
    Online-Ressource
    Fully Printed Light‐Emitting Electrochemical Cells Utilizing Biocompatible Materials
    Wiley ; 2018
    In:  Advanced Functional Materials Vol. 28, No. 24 ( 2018-06)
    Details
    In: Advanced Functional Materials, Wiley, Vol. 28, No. 24 ( 2018-06)
    Kurzfassung: The use of biomaterials and bioinspired concepts in electronics will enable the fabrication of transient and disposable technologies within areas ranging from smart packaging and advertisement to healthcare applications. In this work, the use of a nonhalogenated biodegradable solid polymer electrolyte based on poly(ε‐caprolactone‐ co ‐trimethylene carbonate) and tetrabutylammonium bis‐oxalato borate in light‐emitting electrochemical cells (LECs) is presented. It is shown that the spin‐cast devices exhibit current efficiencies of ≈2 cd A −1 with luminance over ≈12 000 cd m −2 , an order of magnitude higher than previous bio‐based LECs. By a combination of industrially relevant techniques (i.e., inkjet printing and blade coating), the fabrication of LEC devices on a cellulose‐based flexible biodegradable substrate showing lifetimes compatible with transient applications is demonstrated. The presented results have direct implications toward the industrial manufacturing of biomaterial‐based light‐emitting devices with potential use in future biodegradable/biocompatible electronics.
    Materialart: Online-Ressource
    ISSN: 1616-301X , 1616-3028
    URL: Issue
    URL: Article
    DOI: 10.1002/adfm.v28.24
    DOI: 10.1002/adfm.201705795
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2018
    ZDB Id: 2029061-5
    ZDB Id: 2039420-2
    SSG: 11
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
  • 10
    Online-Ressource
    Online-Ressource
    Interpersonal Problems, Dependency, and Self‐Criticism in Major Depressive Disorder
    Wiley ; 2015
    In:  Journal of Clinical Psychology Vol. 71, No. 1 ( 2015-01), p. 93-104
    Details
    In: Journal of Clinical Psychology, Wiley, Vol. 71, No. 1 ( 2015-01), p. 93-104
    Kurzfassung: The goal of the present research was the examination of overlap between 2 research traditions on interpersonal personality traits in major depression. We hypothesized that Blatt's (2004) dimensions of depressive experiences around the dimensions of relatedness (i.e., dependency) and self‐definition (i.e., self‐criticism) are associated with specific interpersonal problems according to the interpersonal circumplex model (Leary, 1957). In addition, we examined correlations of interpersonal characteristics with depression severity. Method Analyses were conducted on 283 patients with major depressive disorder combined from 2 samples. Of the patients, 151 participated in a randomized controlled trial in the United States, and 132 patients were recruited in an inpatient unit in Germany. Patients completed measures of symptomatic distress, interpersonal problems, and depressive experiences. Results Dependency was associated with more interpersonal problems related to low dominance and high affiliation, while self‐criticism was associated with more interpersonal problems related to low affiliation. These associations were independent of depression severity. Self‐criticism showed high overlap with cognitive symptoms of depression. Conclusion The findings support the interpersonal nature of Blatt's dimensions of depressive experiences. Self‐criticism is associated with being too distant or cold toward others as well as greater depression severity, but is not related to the dimension of dominance.
    Materialart: Online-Ressource
    ISSN: 0021-9762 , 1097-4679
    URL: Issue
    URL: Article
    DOI: 10.1002/jclp.2015.71.issue-1
    DOI: 10.1002/jclp.22120
    Sprache: Englisch
    Verlag: Wiley
    Publikationsdatum: 2015
    ZDB Id: 1475037-5
    SSG: 5,2
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    Online-Ressource
Schließen ⊗
Diese Webseite nutzt Cookies und das Analyse-Tool Matomo. Weitere Informationen finden Sie hier...