In:
Angewandte Chemie, Wiley, Vol. 130, No. 6 ( 2018-02-05), p. 1656-1660
Abstract:
Reported for the first time is a tertiary‐alcohol‐guided heteroarylation of remote C(sp 3 )−H bonds. The mild and direct generation of alkoxyl radicals from alcohols is enabled by visible‐light photocatalysis. A remote hydrogen atom and heteroaryl migration sequence are involved in the reaction. Many sensitive groups remain intact in the reaction, thus illustrating wide functional‐group compatibility. This protocol provides a practical strategy for the late‐stage modification of alkyl ketones.
Type of Medium:
Online Resource
ISSN:
0044-8249
,
1521-3757
DOI:
10.1002/ange.201709025
Language:
English
Publisher:
Wiley
Publication Date:
2018
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